Clinical trials: Sedation During, active
Hypoxemia During Surgery
Usefulness of High-flow Oxygen Therapy of Patients at Risk of Hypoxemia Undergoing Digestive Endoscopy Under Deep Sedation
The study investigates the use of high-flow oxygen therapy devices in patients at higher risk of complications during sedated digestive endoscopies.
- Trial name
- ENDOALF-TR (NCT07439822)
- Testing
- High-flow medical oxygen insufflation, Low-flow medical oxygen insufflation
- Where
- Spain
- Volunteers
- 326 people
- Sponsor
- Outcomes'10
Sedation in Non-intubated Diagnostic and Therapeutic Procedures, Sedation
Efficacy and Safety of Nasopharyngeal Tube During Sedation
The goal of this randomized controlled study is to determine whether nasopharyngeal tube oxygenation could increase the fraction of inspired oxygen compared with standard oxygen during a sedated procedure with spontaneous…
- Trial name
- NCT07880002
- Testing
- nasopharyngeal tube, regular cannula
- Volunteers
- 160 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Sedation During GI Endoscopy
Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5…
- Trial name
- NCT07423676
- Volunteers
- 52 people
- Sponsor
- Zagazig University
Atrial Fibrillation, Electric Countershock
BIS-Guided Sedation Versus Standard Clinical Sedation During Elective Electrical Cardioversion for Atrial Fibrillation
Electrical cardioversion (ECV) is a standard procedure used to restore normal heart rhythm in patients with atrial fibrillation (AF) by delivering a brief electrical shock to the heart.
- Conditions
- Atrial Fibrillation, Electric Countershock, Deep Sedation
- Trial name
- BIS-ECV-RCT (NCT07569016)
- Testing
- BIS-guided propofol sedation, Clinical-guided propofol sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Muscle Wasting in Critically Ill
The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients.
- Trial name
- SPICE I (NCT07430969)
- Testing
- NMES, Amino acid bolus (20g), Standard enteral nutrition
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Wageningen University
Sedative During Endoscopy
Implementing Virtual Reality (VR) to Reduce Sedation
The study is a prospective pilot patients aged 21 to 65 undergoing screening colonoscopy or diagnostic upper endoscopy. Patients are administered minimal sedation (2 mg of Versed and 25 mg of Fentanyl) and are given Virtual…
- Trial name
- NCT06349564
- Testing
- Pico 4 Enterprise headset with noise cancelling headphones
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Deep Sedation, Endoscopic Retrograde Cholangiopancreatography
Bispectral Index-Guided Propofol Sedation During Endoscopic Retrograde Cholangiopancreatography
Endoscopic retrograde cholangiopancreatography (ERCP) requires deep sedation, and propofol is commonly used because of its rapid onset and recovery, but it has a narrow therapeutic window, especially in elderly patients.
- Conditions
- Deep Sedation, Endoscopic Retrograde Cholangiopancreatography, Anesthesia Recovery Period
- Trial name
- BIS-ERCP (NCT07922291)
- Testing
- BIS-Guided Propofol Titration, Standard Clinical Propofol Titration
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Stroke Thrombectomy
Mode of Sedation During Endovascular Treatment of Vertebrobasilar Stroke
Optimal anesthetic mode is not established for patients with vertebrobasilar stroke undergoing endovascular treatment. We want to investigate whether a procedural sedation mode approach is feasible compared to general anesthesia
- Trial name
- MOONRISE (NCT05525325)
- Testing
- General Anesthesia
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- University Hospital Heidelberg
Heart Failure, Excessive Amount of Blood / Fluid Transfusion
Anesthesia for Catheter Aortic Valve ImplantATIOn Registry
In modern cardiac surgery and cardiology Transcatheter Aortic Valve Implantation (TAVI) is an emerging procedure for high-risk patients that are assumed to be otherwise inoperable.
- Conditions
- Heart Failure, Excessive Amount of Blood / Fluid Transfusion, Intraoperative Cardiac Arrest During Cardiac Surgery, Critical Incident
- Trial name
- AVIATOR (NCT01390675)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Oxygen Desaturation, Apnea (Central and Obstructive)
Supplemental Oxygen and Oxygen Desaturations in Colonoscopies
This study will compare apnea and oxygen desaturation events among various methods of supplemental oxygen delivery during procedural sedation in colonoscopy patients.
- Conditions
- Oxygen Desaturation, Apnea (Central and Obstructive), Airway Obstruction
- Trial name
- NCT07515755
- Testing
- Breath-synchronized oxygen, CPAP, Control
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Utah
Respiratory Failure
Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane Oxygenation
The goal of this study is to design a pilot trial evaluating the safety, feasibility, pharmacokinetic modeling, and physiological effects of a volatile anesthetic, sevoflurane, directly administered in extracorporeal membrane…
- Trial name
- Vol-ECMO (NCT05680545)
- Testing
- Sevoflurane vaporized in ECMO machines
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Laryngoscopy, Child
Correlation Between Sedation Depth Monitoring and Reflexes During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Undergoing Direct Laryngoscopy for Surgical Procedures
This study evaluates the correlation between sedation depth monitoring obtained by NeuroSENSE ® NS 701 Monitor and reflexes during intravenous anesthesia in children undergoing direct laryngoscopy for surgical procedures.
- Conditions
- Laryngoscopy, Child, Monitoring
- Trial name
- NCT03426579
- Testing
- NeuroSENSE ®in children
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Sedation and Analgesia, Cholangiopancreatography, Endoscopic Retrograde
EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives
Recording and analyzing electroencephalogram (EEG) and continuous pain monitor data under anesthesia in order to investigating the pharmacodynamic effects of opioids and sedatives.
- Conditions
- Sedation and Analgesia, Cholangiopancreatography, Endoscopic Retrograde, Anesthesia, General
- Trial name
- SED-ERCP (NCT07211828)
- Testing
- high dose of alfentanil, low dose of alfentanil with propofol
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chi Kwan Fung
Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy
Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates
About ~3/ 1000 live-born newborns may suffer from brain injury due to a transient drop in oxygen supply to the brain during the birth process.
- Conditions
- Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
- Trial name
- COOL-SED (NCT06985290)
- Testing
- Dexmedetomidine Infusion, Morphine Infusion
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ipsita Goswami
Atrial Fibrillation (AF), Catheter Ablation
Effects of Music During Atrial Fibrillation Ablation Under Conscious Sedation
I. Background Atrial fibrillation, a common type of arrhythmia, is often treated with radiofrequency catheter ablation, a minimally invasive procedure that helps restore a normal heart rhythm.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Pain Management
- Trial name
- NCT06953752
- Testing
- Music intervention, Control
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shaoxing People's Hospital
Colonoscopy Procedures, Sedation
Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy
"This prospective observational study aims to evaluate the effects of adding low-dose ketamine (0.25 mg/kg) to standard propofol sedation on hemodynamic stability, sedation depth, and recovery times in adult patients undergoing…
- Trial name
- NCT07809230
- Testing
- Propofol group, Propofol + Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara Etlik City Hospital
Endoscopic Retrograde Cholangiopancreatography, Conscious Sedation Adverse Event
TEAS for Sedation During ERCP: A Multicenter Trial With Mechanistic Substudy
1. The goal of this clinical trial is to learn if transcutaneous electrical acupoint stimulation (TEAS), a non-invasive therapy that applies mild electrical current to specific points on the skin, can help patients undergoing…
- Conditions
- Endoscopic Retrograde Cholangiopancreatography, Conscious Sedation Adverse Event, Procedural Pain, Sedation-related Complications
- Trial name
- TEAS-ERCP-MC (NCT07440342)
- Testing
- TEAS + Conscious Sedation
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Beijing 302 Hospital
Healthy, Covert Consciousness
Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study
This research is studying whether mental functions take place during different levels of anesthesia, using a commonly used drug (either dexmedetomidine [with propofol in some participants] or ketamine), which shows areas in the…
- Trial name
- NCT07705022
- Testing
- Dexmedetomidine (+propofol as indicated), Ketamine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan