Clinical trials: Sensitivity
Dentin Sensitivity
A Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine Hypersensitivity
The aim of this study is to demonstrate the clinical efficacy of the Test Toothpaste containing Calcium Sodium Phosphosilicate (CSPS) in reducing Dentin Hypersensitivity (DH) to an evaporative (air) stimulus, compared to a sodium…
- Trial name
- NCT07894796
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- HALEON
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Dentin Hypersensitivity
Phase 2 Study of KH001 in Long-term Relief From Dentin Hypersensitivity
The purpose of this study is to evaluate the efficacy and safety of KH001 in subjects with dentin hypersensitivity.
- Trial name
- NCT06464939
- Testing
- KH001
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- HysensBio Co., Ltd
Migraine, Photophobia
Impact of Optimized White Light on Visual Discomfort, Headache Intensity, and Cognitive Performance Among Those With Migraine
The goal of this research is to study how effective an optimized white light is for improving visual comfort and reducing migraine symptoms.
- Conditions
- Migraine, Photophobia, Cognitive Function Assessment, Headache
- Trial name
- NCT07898722
- Testing
- Optimized Ambient White Light, Conventional White Light
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Insulin Sensitivity/Resistance
Aerobic Versus Resistance Exercises on Insulin Sensitivity in Obese Patients
The purpose of study is to compare the effect of different exercise modes on insulin resistance and body composition in obese patients.
- Trial name
- NCT06772857
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dentin Hypersensitivity
Laser Therapy for Dentin Hypersensitivity
This split-mouth randomized controlled clinical trial compared the effectiveness of Er,Cr:YSGG laser irradiation, a hydroxyapatite- and fluoride-containing agent (Remin Pro), and their combined application in the treatment of…
- Trial name
- NCT07431736
- Testing
- Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD, Remin Pro (VOCO, Cuxhaven, Germany)
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Hacettepe University
ICU Staff Attitudes Toward Family Presence, ICU Staff Experience of Family Presence
Attitudes, Experience and Adaptation to Family Presence in the ICU
The goal of the study is to verify how healthcare professionals in the Intensive Care Unit (ICU) experience the presence of family members before and after a more flexible visiting policy is introduced.
- Conditions
- ICU Staff Attitudes Toward Family Presence, ICU Staff Experience of Family Presence, Adaptation to Extended Family Presence in the ICU, Association Between Stress Sensitivity and Attitudes Toward Family Presence
- Trial name
- RUIMIZ (NCT07887009)
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hypersensitivity Dentin, Dental Restoration Failure of Marginal Integrity
Clinical Evaluation of Short Dentin Etching
To evaluate and compare the two-year clinical performance of Class I resin composite restorations utilizing a universal adhesive used in different etch-and-rinse strategies (15-second and 5-second etching) and self-etch…
- Trial name
- NCT06772051
- Testing
- Resin composite restoration bonded using universal adhesive in etch and rinse mode (15 seconds etching), Resin composite restoration bonded using universal adhesive in etch and rinse mode (5 seconds etching), Resin composite restoration bonded using universal adhesive in self-etch mode
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH)
Clinical Comparison of CAD/CAM Nanohybrid Composite and Hybrid Ceramic Overlays in Children With Molar-Incisor Hypomineralisation
This clinical study was conducted to compare two different dental materials used in the treatment of children who have a condition called molar-incisor hypomineralization (MIH).
- Conditions
- Enamel Hypoplasia, Molar-Incisor Hypomineralization (MIH), Restoration of Permanent Molars Affected by MIH With CAD/CAM Blocks
- Trial name
- NCT06987448
- Testing
- Semi-direct onlay restoration using CAD/CAM hybrid composite block, Semi-direct onlay restoration using CAD/CAM hybrid ceramic block
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Alp Akça
Dentin Sensitivity
Clinical Study to Investigate the Ability of a Stannous Fluoride Toothpaste to Protect From Dentine Hypersensitivity
The purpose of this study is to investigate and characterize the Dentine Hypersensitivity (DH) protection profiles of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste and a regular fluoride toothpaste, in response to…
- Trial name
- NCT06733285
- Testing
- Sensodyne Rapid Relief, Colgate Cavity Protection
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Sensitivity, Dentin Hypersensitivity
Efficacy of a Sonic Toothbrush and 8% Arginine Toothpaste in Reducing Dentinal Hypersensitivity
This clinical study evaluates the efficacy of an oral hygiene regimen consisting of an electric sonic toothbrush used in combination with an 8.0% arginine and calcium carbonate toothpaste in reducing dentinal hypersensitivity…
- Trial name
- NCT07871786
- Testing
- 8.0% Arginine Dentifrice, Electric Sonic Toothbrush, Adult Soft Bristle Manual Toothbrush
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Colgate Palmolive
Adiposity, Insulin Sensitivity
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners…
- Conditions
- Adiposity, Insulin Sensitivity, Weight Gain, Blood Pressure
- Trial name
- NCT05992688
- Testing
- Sucrose sweetened beverage, Stevia sweetened beverages, Calorie free flavored water beverage
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Tooth Discoloration
450 nm Blue Diode Laser Versus Blue LED for In-Office Tooth Bleaching
Tooth discoloration is commonly managed using in-office dental bleaching. This randomized clinical trial compared the efficacy and safety of activating the same 35% hydrogen peroxide bleaching gel with either a 450 nm blue diode…
- Trial name
- NCT07870317
- Testing
- 450 nm Blue Diode Laser, Blue Light-Emitting Diode Lamp, 35% Hydrogen Peroxide Dental Bleaching Gel
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Misr University for Science and Technology
Dentin Sensitivity
Comparison of Post-Operative Sensitivity of 5th Genaration Bonding Agent With 8th Generation Bonding Agent in Class1 Composite Restoration
The goal of this randomized clinical trial is to compare post-operative sensitivity after Class I composite restorations using 5th-generation and 8th-generation bonding agents in adults aged 18 to 50 years.
- Trial name
- NCT07862270
- Testing
- 5th generation bonding agent, 8th generation bonding agent
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rehman Medical Institute - RMI
Diabetes Mellitus, Insulin Sensitivity
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
The primary objective of Study GZQG is to compare the effect of retatrutide and placebo on total clamp disposition index (cDI) after 28 weeks of treatment.
- Trial name
- NCT06982859
- Testing
- Retatrutide, Semaglutide
- Where
- Germany
- Volunteers
- 95 people
- Sponsor
- Eli Lilly and Company
Obesity and Obesity-related Medical Conditions, Obesity and Overweight
Response to Semaglutide in Non-diabetic Obese Patients With Varying Degrees of Insulin Resistance
Incretin mimetics are widely used pharmacological treatments for weight loss, known for their high efficacy and favorable safety profile.
- Conditions
- Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Insulin Sensitivity/Resistance, Semaglutide
- Trial name
- TRIM-IR (NCT06856291)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- ETH Zurich
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity: A Pilot Study
The goal of this observational study is to investigate whether differences in oral proprioceptive sensitivity are associated with differences in kinesthetic acuity of the upper limbs in children.
- Trial name
- NCT07854314
- Testing
- Upper-Limb Kinesthetic Acuity Assessment, Effect of Auditory Stimulation on Visual Perception, Oral Proprioceptive Sensitivity Assessment
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sophie Román Richon
Digestive Health, Gastrointestinal Health
The Effects of Oral Fructanase Administration on Gastrointestinal Symptoms After Inulin Challenge in Healthy Adults
The carbohydrate inulin (from chicory root) is a healthy prebiotic ingredient found in dietary supplements and fortified foods (Nagy et al).
- Conditions
- Digestive Health, Gastrointestinal Health, FODMAP Intolerance, Food Sensitivity
- Trial name
- NCT06628869
- Testing
- Fructanase
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BIO-CAT, Inc.
Dysphotopsia, Posterior Capsule Opacification
Clinical Evaluation of Low Contrast Visual Performance and Low Light Phenomena in Patients With Various Intraocular Lens Implants
The goal of this clinical investigation is to evaluate visual acuity and contrast sensitivity in low lighting conditions using several different testing devices, and measure nighttime side effects of intraocular lens (IOL)…
- Conditions
- Dysphotopsia, Posterior Capsule Opacification, Visual Acuity, Visual Function
- Trial name
- NCT07213167
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Dr. Daniel H. Chang, MD
Insomnia, Healthy Adult
The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise-induced Muscular Pain
Sleep is a critical determinant of physiological recovery and pain regulation. Growing evidence suggests that sleep disruption directly heightens central and peripheral pain sensitivity to sensory stimuli (e.g., mechanical…
- Conditions
- Insomnia, Healthy Adult, Musculoskeletal Pain, Pain Sensitivity
- Trial name
- NCT07827664
- Testing
- Eccentric exercise
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University