Clinical trials: Sensitization, Central
Chronic Migraine
Effect of Nebulized Dexmedetomidine on Central Sensitization and Chronification in Migraine
Migraine is a debilitating neurological disorder characterized by recurrent headaches episodes, often accompanied by amplified perception of multiple sensory inputs such as cutaneous allodynia, photophobia, and phonophobia.
- Trial name
- NCT07769255
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Beni-Suef University
Central Sensitisation, Postoperative Pain
Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery
The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery.
- Conditions
- Central Sensitisation, Postoperative Pain, Arthritis
- Trial name
- NCT06553118
- Testing
- Total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Central Sensitisation, Fibromyalgia
The Relationship Between Neuropathic Complaints and Central Sensitization in Fibromyalgia
Fibromyalgia (FM) is the prototype of a group of diseases known as central sensitivity syndromes, whose relationship with pain sensitization is well defined.
- Conditions
- Central Sensitisation, Fibromyalgia, Neuropathic Pain
- Trial name
- NCT05701696
- Testing
- Central sensitization inventory, Widespread pain index, Symptom severity scale
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Marmara University
Subacromial Pain Syndrome, Central Sensitisation
The Effect of Manual Therapy on Central Sensitization
Subacromial pain syndrome (SIS) is a common cause of shoulder pain, estimated to be the cause for up to half of incident cases. Typically, pain is generated with elevation of the arm above the head though it can occur with rest…
- Trial name
- NCT05524870
- Testing
- Mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Cukurova University
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Fibromyalgia
Effectiveness of Electro Neuro Adaptive Regulator in Patients With Fibromyalgia
Background: There is evidence linking conditioned pain modulation (CPM) deficiency with musculoskeletal pain syndromes such as fibromyalgia, Evidence shows that different physical therapies could activation situations of chronic…
- Trial name
- SCENAR (NCT03882567)
- Testing
- Electro Neuro adaptative Regulator
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad Rey Juan Carlos
Neck Pain
Chronic Neck Pain and Central Sensizitation
Chronic neck pain is one of the musculoskeletal pain problems that can cause chronic disability. It is emphasised that individuals with chronic neck pain have difficulty during different activities in their daily lives, and that…
- Trial name
- NCT06976398
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Thoracic Outlet Syndrome
Motivational Interviewing in Thoracic Outlet Syndrome
The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS).
- Trial name
- NCT07668206
- Testing
- Motivational Interviewing, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Cervicogenic Headache, Proprioceptive Disorders
Manual Therapy vs. Multicomponent Exercise in Cervicogenic Headache
The purpose of this study is to compare the effects of manual therapy and a multicomponent exercise program on suboccipital muscle thickness, joint position sense, pain, central sensitization, balance, and kinesiophobia in…
- Conditions
- Cervicogenic Headache, Proprioceptive Disorders, Neck Pain Musculoskeletal
- Trial name
- NCT07776093
- Testing
- Manual Therapy Protocol, Multicomponent Exercise Program
- Volunteers
- 32 people
- Sponsor
- Pamukkale University
Osteoarthritis
Effects of Duloxetine on Pain Relief After Total Knee Arthroplasty in Central Sensitization Patient
This study aims to compare the effectiveness of duloxetine after total knee arthroplasty in Central sensitization patient. Central sensitization plays an important role in the chronic pain experienced by osteoarthritis…
- Trial name
- NCT02600247
- Testing
- Duloxetine, celecoxib, Pregabalin, acetaminophen/tramadol, oxycodone
- Volunteers
- 100 people
- Sponsor
- The Catholic University of Korea
Subacromial Pain Syndrome, Central Sensitisation
The Segmental Distribution of Hypersensitivity in Patients With Chronic Subacromial Pain Syndrome
This study aimed to determine the distribution of pain sensitivity according to body segments in patients with central sensitization associated with chronic subacromial pain syndrome (SPS).This cross-sectional study included…
- Trial name
- NCT06139120
- Testing
- Assessment of hypersensitivity
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Parkinson Disease
DESENSITIZE-PD: Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Support Dopaminergic Desensitization in PD
20 patients with idiopathic Parkinson's disease, who are planned to undergo intestinal L-Dopa + entacapone (Lecigon®) treatment will be included into this observational single-armed study.
- Trial name
- NCT05579379
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Renal Failure , Chronic, Graft Failure
Study to Compare the Outcome of Receiving Continued Immunosuppression Versus Stopping Immunosuppression at 6 Months to Safely Prevent Human Leukocyte Antigen (HLA) Sensitization in Patients With Late Renal Graft Failure
The goal of this clinical trial is to compare the degree of HLA sensitization at 2 years in patients with late renal graft failure (> 3 months) when receiving reduced immunosuppressant treatment versus stopping immunosuppression…
- Conditions
- Renal Failure , Chronic, Graft Failure, Graft Rejection, Allograft
- Trial name
- NCT06676696
- Testing
- Continue low dose calcineurin inhibitor (CNI), Calcineurin inhibitor withdrawal at 6 months
- Where
- Spain
- Volunteers
- 202 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Pain, Postoperative Pain
Risk of Failed Epidural in Patients With and Without Chronic Pain and Opioid Use
Patients with chronic pain syndrome (CPS) may develop central sensitization wich may lead to increased pain intensity and lower pain threshold sometimes to the extend of hyperalgesia and allodynia.
- Conditions
- Chronic Pain, Postoperative Pain, Central Sensitisation
- Trial name
- NCT05662566
- Testing
- Epidural replacement
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Eske Kvanner Aasvang
Thoracotomy, Hyperalgesia
Central Sensitisation and Postoperative Pain
One out of 10 patients undergoing surgery develops persistent post-surgical pain (PPSP). Unfortunately, available therapies for treating this pain have limited success.
- Conditions
- Thoracotomy, Hyperalgesia, Hyperalgesia, Secondary, Central Sensitisation
- Trial name
- NCT04220697
- Testing
- electroencephalography (EEG), questionnaires, high frequency electrical stimulation of the forearm skin (HFS)
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- Université Catholique de Louvain
Central Sensitisation, Axial Spondyloarthritis
The Relationship Between Magnetic Resonance Imaging (MRI) Scores and Sensory Testing in Axial Spondyloarthritis
Axial spondyloarthritis is one of the most common rheumatic diseases and chronic pain and morning stiffness are the main complaints of these patients.
- Conditions
- Central Sensitisation, Axial Spondyloarthritis, Inflammation
- Trial name
- NCT05021783
- Testing
- Pressure pain threshold, Central Sensitization Inventory, Spondyloarthritis Research Consortium of Canada scoring system
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Marmara University
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Menopause, Healthy Female Participants
A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System (TDS). The comparator drug is the Climara Pro® TDS.
- Trial name
- NCT07794150
- Testing
- Estradiol/Levonorgestrel Transdermal System
- Where
- 2 sites in United States, India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Frozen Shoulder, Central Sensitisation
Relationship Between Central Sensitization Levels and Treatment Outcomes in Frozen Shoulder Treatment
The aim of this study was to evaluate the relationship between treatment outcomes and central sensitization levels in patients who received intra-articular injections for frozen shoulder.
- Conditions
- Frozen Shoulder, Central Sensitisation, Treatment, Intra-Articular Injection
- Trial name
- NCT07124689
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Sultan 1. Murat State Hospital
Endometriosis, Pain
Quantitative Sensory Testing and Central Sensitization in Endometriosis
Endometriosis is a gynecologic condition where there is growth of endometrial-like tissue outside the uterus, leading to severe pelvic pain.
- Trial name
- NCT06215937
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- BC Women's Hospital & Health Centre