Clinical trials: Sensitization, Central
Osteoarthritis
Neuroscience Education on Osteoarthritis
Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great disability and significant healthcare costs. Substantial scientific evidence indicates a role for central sensitization in OA pain.
- Trial name
- NCT02246088
- Testing
- MT + NE, MT + E
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- University of Valencia
Endometriosis
Central Awareness in Women With Endometriosis
Gathering some information obtained during the gynaecological examination and transvaginal ultrasound check-up to be able to assess the prevalence of Central Sensitisation Syndrome (CSS) in women with endometriosis and also to be…
- Trial name
- NCT06773065
- Where
- Italy
- Volunteers
- 310 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Plaque-type Psoriasis
Serum Substance P, Neuropathic Pain, and Central Sensitization Across Treatment Groups in Chronic Plaque Psoriasis
The goal of this observational study is to better understand whether blood levels of Substance P are related to pain, itching, altered pain sensations, central sensitization, psoriasis severity, and quality of life in adults with…
- Trial name
- NCT07844772
- Testing
- IL-17 Inhibitor Therapy, Conventional Systemic Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Training and Research Hospital
Pain, Esophageal Sensitivity
Esophageal Hypersensitivity Study in Healthy Volunteers
The purpose of the study is to compare sensitivity and sensitization of visceral pain in the esophagus using different pain stimuli
- Trial name
- NCT00711048
- Testing
- AZD1386
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronotype, Fibromyalgia Syndrome
Evaluation of Chronotype and Central Sensitization in Patients With Fibromyalgia Syndrome
The aim of study is to examine the chronotype preferences of patients with fibromyalgia syndrome and the relationship between central sensitization and chronotype, and to examine its relationship with pain intensity, disability…
- Trial name
- NCT06197087
- Testing
- cross-sectional observational survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Oğuzhan Kandemir
Rotator Cuff Tears, Central Sensitisation
Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair.
- Conditions
- Rotator Cuff Tears, Central Sensitisation, Neuropathic Pain
- Trial name
- NCT06367998
- Testing
- Pregabalin
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Plaque Psoriasis, Fibromyalgia
Prevalence of Fibromyalgia in Patients With Plaque Psoriasis
This observational study aims to determine how common fibromyalgia syndrome and central sensitization are in adults with plaque psoriasis compared to healthy individuals.
- Trial name
- NCT07773766
- Volunteers
- 110 people
- Sponsor
- Assiut University
Pain
Remote Ischemic Preconditioning Mechanism Study
This research is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury.
- Trial name
- NCT01541436
- Testing
- Remote Ischemic Preconditioning, Capsaicin, UV-B
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Non-specific Chronic Low Back Pain
The Effect of Body Awareness on Pain, Disability, Sensorimotor Acuity, Psychosocial and Central Sensitization Levels in Individuals With Non-Specific Chronic Low Back Pain
This study will be conducted to examine the levels of pain, pressure pain threshold, joint position sense, sensation, functionality, pain catastrophizing, central sensitization, and body awareness in individuals with non-specific…
- Trial name
- NCT07296185
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medipol University
Joint Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Central Sensitization and Physical Activity in Adolescents With HSD/hEDS
Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.
- Trial name
- NCT05633225
- Testing
- Submax exercise test on a bicycle ergometer
- Where
- 2 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Temporomandibular Disorder
Assessment of Nociceptive Processing Among Patients With Temporo-mandibular Disorders
This case control study will investigate the physiological effect of nociceptive input in individuals with temporomandibular disorders.
- Trial name
- NCT04086732
- Testing
- High-frequency electrical stimulation
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Covid19
poSt Covid-19 Infection centraL sENsitisaTion
The aim of this study is to evaluate whether there are indicators of central sensitisation in patients post covid-19 infection.
- Trial name
- SILENT 1 (NCT04703452)
- Testing
- Indicators of central sensitisation
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Central Sensitisation
Investigating the Association Between Central Sensitization and Breathing Pattern Disorders
Breathing pattern disorders can cause mechanical, physiological, and psychological issues in the body, contributing to the initiation and chronicity of pain.
- Trial name
- NCT06485414
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Sahmyook University
Central Sensitization, Low Back Pain
Verbalization in Patients With Non-specific Low Back Pain and Central Sensitization
The primary goal of this study is to examine the effects of limiting complaints on pain and pain catastrophizing (PC) in individuals with low back pain (LBP) who are in a state of central sensitization (CS).
- Conditions
- Central Sensitization, Low Back Pain, Pain Catastrophizing
- Trial name
- NCT01705600
- Testing
- Pain Verbalization Repression Rules
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Keystone Rehabilitation Systems
Axial Spondyloarthritis, Central Sensitisation
Investigation of Central Sensitization Frequency and Related Factors in Axial Spondyloarthritis Patients
The term axial spondyloarthritis (axSpA) describes a group of chronic inflammatory diseases that characterized with spinal involvement.
- Trial name
- NCT04485078
- Testing
- Pressure pain threshold, Temporal summation, Conditioned pain modulation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Marmara University
Fibromyalgia
Suprathreshold Pressure Pain Stimulation in Fibromyalgia
The purpose of this study is to investigate the induced-pain characteristics after suprathreshold pressure stimulation at different intensities in fibromyalgia subjects, compared with healthy volunteers.
- Trial name
- NCT04047407
- Testing
- Suprathreshold pain stimulation
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Migraine Disorder, Episodic Migraine
Neurophysiological and Biomolecular Effects of Atogepant in Episodic Migraine
The investigators aim to assess and compare neurophysiological and biochemical changes induced by a 3-month treatment with atogepant (60 mg daily) in patients with high-frequency episodic migraine (8-14 monthly migraine days).
- Trial name
- ATOM (NCT06882122)
- Testing
- Atogepant 60 mg
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Chronic Shoulder Pain
Influence of Biopsychosocial Factors and Central Sensitization in Predicting the Recovery of Chronic Shoulder Pain
Background: Shoulder pain is the third most common musculoskeletal condition presenting to physicians or physiotherapists ) in primary healthcare after low back and neck pain being a significant cause of morbidity and functional…
- Trial name
- NCT02738372
- Testing
- Diagnosis/Prognosis
- Volunteers
- 90 people
- Sponsor
- University of Malaga
Lumbar Radiculopathy, Central Sensitisation
Identifying Pain Generators and Potentiators of Residual Complaints Following Lumbar Discectomy
Lumbar discectomy (i.e. surgically removing a hernia) is frequently performed in Belgium to treat lumbar radiculopathy. Every year >12,000 interventions are performed with variable long-term results.
- Trial name
- DISC-PAIN (NCT05022251)
- Testing
- Lumbar discectomy
- Where
- Belgium
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Ghent