Clinical trials: Sensitization, Central
Chronic Low-back Pain
Mechanisms of Chiropractic Spinal Manipulation for Chronic Low Back Pain
This is a mechanistic randomized controlled trial on the effects of chiropractic spinal manipulative therapy on patients with chronic low back pain.
- Trial name
- NCT05162924
- Testing
- Spinal Manipulation
- Where
- Spain
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Real Centro Universitario Maria Cristina
Ankylosing Spondylitis, Peripheral Neuropathies
Assessment of Peripheral Neuropathy in Ankylosing Spondylitis
investigators hypothesized that peripheral neuropathy in ankylosing spondylitis is associated with higher disease activity, greater central sensitization, worse functional impairment, and poorer quality of life.
- Trial name
- NCT07641920
- Testing
- Nerve conduction study
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Central Sensitisation, Carpal Tunnel Syndrome
Investigation of the Relationship Between Pain Sensitization and Diagnostic Parameters in Carpal Tunnel Syndrome
The aim of this observational, cross-sectional study is to investigate the relationship between pain sensitization and ultrasonographic and nerve conduction studies in patients diagnosed with carpal tunnel syndrome (CTS).
- Trial name
- NCT06043141
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Adenomyosis
Central Sensitization in Women With Adenomyosis: Prevalence, Risk Factors, and Therapeutic Failure
This is an observational, prospective, multicenter, non-profit study. The study aims to investigate the association between the Central Sensitization Inventory (CSI) score and the presence of Central Sensitization Syndrome (CSS)…
- Trial name
- ADENOCS (NCT07455721)
- Where
- 14 sites in Italy
- Volunteers
- 1,200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fibromyalgia (FM), Chronic Pain
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Symptom Severity, Sleep Quality, Central Sensitization, and Kinesiophobia in Fibromyalgia
Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and sensitivity to touch. Current treatments often provide only partial relief.
- Trial name
- NCT07173400
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hatice Betigul Meral
Neuropathic Pain
The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty
It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA).
- Trial name
- NCT05581836
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- The Catholic University of Korea
Knee Osteoarthritis, Central Sensitisation
Relationship Between Central Sensitization and Kinesiophobia in Knee Osteoarthritis
Objective: The knee joint is one of most common locations in OA. In recent years, it has been accepted that there are different pain phenotypes and patient subgroups in knee OA and that central sensitization (CS) mechanisms are…
- Conditions
- Knee Osteoarthritis, Central Sensitisation, Kinesiophobia
- Trial name
- NCT06336278
- Testing
- Pressure Algometer
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Selda Sarıkaya
Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Neuropathic Pain in Lumbar Disc Herniation
Central sensitization (CS) is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several…
- Trial name
- NCT06269068
- Testing
- Central sensitization inventory, Short form-36, Oswestry Low Back Pain Disability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Marmara University
Fibromyalgia Syndrome, Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Balance in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and changes in static and dynamic balance in patients with fibromyalgia.
- Conditions
- Fibromyalgia Syndrome, Central Sensitisation, Postural Balance
- Trial name
- NCT06851091
- Testing
- Biodex Balance System, Pressure Pain Threshold (PPT) Measurement with Algometer, Conditioned Pain Modulation (CPM)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Chronic Pain
Central Sensitization in Chronic Whiplash Patients
The purpose of this study is to determine whether the metabolite concentrations within the anterior cingulate cortex and periaqueductal gray matter predict the intensity and interference of neuropathic pain after the development…
- Trial name
- NCT03005691
- Testing
- Spectroscopy, Questionnaires, Conditioned Pain Modulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Fibromyalgia
FIbromyalgia anD GenetIcs Subgroups (FIDGIS)
Fibromyalgia syndrome (FS) is characterized by widespread pain and affect 0.5 to 5 % of the general population, with a higher prevalence in women.
- Trial name
- FIDGIS (NCT04624581)
- Testing
- Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Central Sensitization
The Role of Central Sensitization in Pain, Functionality, and Quality of Life in Cancer Patients
Pain is one of the most important and challenging symptoms in cancer patients. Depending on the stage of cancer, approximately 40% to 70% of patients complain of pain.
- Trial name
- NCT06418399
- Testing
- cancer patients
- Volunteers
- 1,000 people
- Sponsor
- Marmara University
Cervicogenic Headache, Central Sensitization
Central Sensitization and Neuropathic Pain in Cervicogenic Headache
Cervicogenic headache is a type of secondary headache that originates from the structures of the neck and can spread toward the head and facial regions.
- Conditions
- Cervicogenic Headache, Central Sensitization, Neuropathic Pain
- Trial name
- NCT07292181
- Testing
- Clinical assessment with standardized questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Postoperative Pain, Chronic Postsurgical Pain
Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery
Postoperative pain remains a common and clinically important burden after thoracic surgery and may progress to chronic postsurgical pain.
- Conditions
- Postoperative Pain, Chronic Postsurgical Pain, Thoracic Surgery, Lung Resection
- Trial name
- NCT07653932
- Testing
- Perioperative QST and incision pain mapping assessment
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Tongji Hospital
Sensitisation, Highly Sensitised Dialysis Patients
The Safety/Efficacy Of Daratumumab With Belatacept In Highly HLA-Sensitized Patients Awaiting Kidney Transplantation
While the number of kidney transplants is increasing worldwide every year, there is a clear imbalance between the high number of patients in the waiting list and those receiving a transplant and importantly, among waitlist…
- Trial name
- COMBAT (NCT05145296)
- Testing
- Each patient will undergo in the first step of the study belatacept treatment and in the second apheresis and daratumumab
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Grenoble
Central Sensitisation
Quantitative Ultrasound Response of Capsaicin
Central Sensitization is an aspect of chronic pain and is associated with over-excitability of the central nervous system. Central Sensitization normally presents itself with other chronic syndromes such as Myofascial Pain…
- Trial name
- QUROC (NCT03944889)
- Testing
- Capsaicin, Delsys Trigno Galileo System, Cadwell Sierra Wave
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Toronto Rehabilitation Institute
Central Sensitization, Manual Therapy
Efficiency of Manual Therapy on Central Sensitization in Patients With Nonspecific Chronic Back Pain
Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input.
- Trial name
- NCT05937503
- Testing
- manual therapy, conventional physiotherapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Atılım University
Fibromyalgia
Effects of Milnacipran on Widespread Mechanical and Thermal Hyperalgesia of Fibromyalgia Patients
Fibromyalgia syndrome (FM) shares many symptoms common to chronic neuropathic pain, including the characteristic hyperalgesia of the skin (thermal, mechanical) and muscles (mechanical) found in almost all FM patients.
- Trial name
- NCT01294059
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Florida
Chronic Low-back Pain
The METRIC Study Protocol
The goal of this clinical trial is to test the effects of spinal manipulative therapy in individuals with chronic primary low back pain and determine the neurophysiological mechanisms underlying pain relief.
- Trial name
- METRIC (NCT05986370)
- Testing
- lumbar spinal manipulative therapy, full spine spinal manipulative therapy
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Central Sensitisation, Chronic Musculoskeletal Disease
The Frequency of Central Sensitization in Patients With Chronic Musculoskeletal Pain
Central sensitization is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several…
- Conditions
- Central Sensitisation, Chronic Musculoskeletal Disease, Chronic Pain
- Trial name
- NCT04765280
- Testing
- Central sensitization inventory, Short form-36, Istanbul Low Back Pain Disability Index
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Marmara University