Clinical trials: Sensitization
Erythema, Sensitisation
50 Human Subject Repeat Insult Patch Test
Consumer products or raw materials designed for consistent reapplication to areas of the skin may, under proper conditions, prove to be contact sensitizers or irritants in certain individuals.
- Trial name
- HRIPT (NCT04498676)
- Testing
- CB-0002B
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CAGE Bio Inc.
Chronic Pain Syndrome, Sensitization, Central
Management of Chronic Non-Cancer Pain With Non-Pharmacological Therapies
A randomized controlled clinical trial will be conducted, involving a psychoeducational activity as the intervention. There will be a control group of patients with non-cancer chronic pain who will continue their usual treatment.
- Conditions
- Chronic Pain Syndrome, Sensitization, Central, Quality of Life, Patient Empowerment
- Trial name
- NCT06440668
- Testing
- Chronic Pain Management Workshop with Non-Pharmacological Therapies
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hospital San Juan de Dios del Aljarafe de Sevilla
Osteoarthitis
The 'Bone-Brain' Crosstalk Mechanism of Subchondral Bone Nociceptive Sensitization Activating SPP1-Positive Microglia in the vlPAG Region Elucidates the Theoretical Connotation of Treating Knee Osteoarthritis Based on Kidney Differentiation
The aim of this observational study is to investigate the relationship between pain severity and alterations in bone-derived and brain-derived signaling molecules (including serum neurotransmitters and inflammatory cytokines), as…
- Trial name
- NCT06977282
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jinchao Xu
Plantar Fasciitis
Relationship Between Central Sensitization and Clinical Features in Plantar Fasciitis
Plantar fasciitis is a common cause of heel pain and is traditionally considered a mechanical musculoskeletal disorder. Recent evidence suggests that central sensitization may also contribute to pain in individuals with plantar…
- Trial name
- NCT07640620
- Testing
- Pressure Pain Threshold Assessment, Ultrasonographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Skin Irritation
Patch Test Skin Irritation/Sensitization of Cetaphil Restoraderm Skin Restoring Body Wash
Determine if Cetaphil Restoraderm Skin Restoring Body Wash proves to be a contact sensitizer or irritant in certain individuals.
- Trial name
- NCT01892410
- Testing
- Cetaphil Restoraderm Skin Restoring Body Wash
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Osteoporosis, Postmenopausal
A Multiple-Dose Study to Evaluate Skin Irritation and Sensitization of Teriparatide Administered Transdermally in Healthy Postmenopausal Women
This study is a Phase 1, multi-center, 2-part, subject- and investigator-blind, randomized, placebo-controlled, multiple dose study of transdermal teriparatide (80-µg dose) in healthy postmenopausal women.
- Trial name
- NCT01250145
- Testing
- LY333334
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Skin Reaction to Mechanical, Thermal and Radiation Stimuli, Skin Sensitisation
Study Comparing iNPWT Dressing and Devices Affect on Bioburden Levels and Skin Condition After Seven Days
Incisional dressings aim to prevent contamination of an incisional wound and protect against skin irritation. Surgeons use incisional negative pressure wound therapy (iNPWT) to manage incisional wounds.
- Trial name
- HHiNPWT7DC (NCT05559697)
- Testing
- Sponsor incisional negative pressure wound therapy device and dressing, Standard of Care incisional negative pressure wound therapy system
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- DeRoyal Industries, Inc.
Behcet's Disease, Central Sensitisation
Assessment of Central Sensitization, Neuropathic Pain, Sleep Quality and Daily Life Activities in Behcet's Disease
There are few studies in the literature regarding increased frequency of neuropathic pain and sleep disturbance and decreased quality of life in Behçet's disease.
- Trial name
- NCT03531385
- Testing
- Central sensitisation, Neuropathic pain, Sleep disturbance
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Female Dry Genital Mucosa
Dermal and Gynecological Acceptability (Irritability and Sensitization in the Genital Mucosa) of an Investigational Product and Evaluation of Moisture Efficacy by TEWL and Perceived Efficacy.
To evaluate the safety of an investigational product through the verification of signs of irritability and sensitization of the genital mucosa, as well as the instrumental moisturizing efficacy by TEWL and barrier integrity…
- Trial name
- DERM GYN ACCEP (NCT03007615)
- Testing
- Intimate Lubricant Gel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Chronic Low Back Pain
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements.
- Trial name
- NCT00899600
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy
Phase I Study to Assess Irritation, Sensitization and Adhesion of a Novel Ibuprofen 200 mg TEPI Medicated Plaster
This trial will be conducted with the aim to investigate the dermal response (skin irritation, sensitization) and the adhesion of Ibuprofen 200 mg TEPI Medicated Plaster as compared to a Placebo TEPI Plaster in two phases…
- Trial name
- NCT03639571
- Testing
- Ibuprofen 200 mg TEPI Medicated Plaster
- Where
- Bulgaria
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medherant Ltd
Sensitivity, Contact
Sensitization Study of ATx201 in Healthy Volunteers
This is a Phase I, single-site study to evaluate the sensitization potential of topically applied ATx201 GEL, 2% and 4%, along with a placebo control, in healthy human subjects.
- Trial name
- NCT03375957
- Testing
- ATx201
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- UNION therapeutics
Central Sensitisation, Musculoskeletal Diseases
Physical Therapy Management Of The Patient With Central Sensitization
In the literature there is still debate about the concept of central sensitization, as a pain mechanism that can support a neuromusculoskeletal pathology and which for Woolf corresponds to an amplification of neural signaling…
- Conditions
- Central Sensitisation, Musculoskeletal Diseases, Pain
- Trial name
- NCT05062694
- Testing
- Survey
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Skin Care
A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
The purpose of this study is to demonstrate the absence of sensitisation and irritation potential of a product when applied to the skin and exposed to ultraviolet (UV) radiation.
- Trial name
- NCT04006795
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lateral Epicondylitis, Central Sensitization
Central Sensitization and Ultrasound in Lateral Epicondylitis
Lateral epicondylitis (LE) is a common musculoskeletal disorder characterized by pain and tenderness over the lateral elbow and may become chronic despite conservative treatment.
- Trial name
- NCT07827898
- Testing
- Pressure pain threshold, Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Major Depressive Disorder (MDD)
A Study to Assess the Skin Irritation and Sensitization of Selegiline TDS in Healthy Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Selegiline Transdermal Delivery System (TDS). The comparator drug is the EMSAM® TDS.
- Trial name
- NCT07452692
- Testing
- Selegiline Transdermal Delivery System
- Where
- 3 sites in Bulgaria
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Alpha-Gal Syndrome
The α-gal Syndrome - Investigating Immune Reactions to Tick Bites
Tick bites can transmit pathogens, but they can also induce a food allergy to mammalian meat. The goal of this clinical trial is to follow immune response and antibody build-up in individuals bitten by a tick.
- Trial name
- ImmunoGal (NCT07177729)
- Where
- 2 sites in Luxembourg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Osteoarthritis, Knee
Effects of Central Sensitization on Response to Conventional Physical Therapy in Patients With Knee Osteoarthritis
The aim of this study was to investigate the relationship between central sensitization (CS) and poor response to conventional physical therapy in patients with knee osteoarthritis (OA) by evaluating clinical parameters of pain…
- Trial name
- NCT05518097
- Testing
- Conventional physical therapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Oral Manifestations
Oral Irritation Study of Two Experimental Mouthrinses
This study is 25 days long. People participating in this study will be asked to brush their teeth two times a day. People will be assigned to a mouthwash and will rinse four times a day at the site for five days.
- Trial name
- NCT01156376
- Testing
- Potassium Oxalate without Fluoride, Potassium Oxalate with Fluoride, Active Comparator PO-116-A
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital