Clinical trials: Sentinel Lymph Node Detection
Endometrial Cancer
Detection of SLN in Patients With Endometrial Cancer Undergoing Robotic Assisted Staging: Comparison of ISB and ICG
The investigators hypothesis is that if sensitivity and specificity are found to be significantly higher than the current reports with Technesium-99 and ISB colorimetric dye, SLN biopsies might allow omission of full…
- Trial name
- NCT02068820
- Testing
- ISB dye and standard white light imaging, ICG dye and FireFly fluorescence imaging
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- AdventHealth
Ovarian Cancer, Sentinel Node
Sentinel Node Detection in Clinical Early Stage Ovarian Cancer
As most cancers, ovarian cancer also spreads to regional lymph nodes. The concept of sentinel lymph node surgery is to see whether the cancer has spread to the very first lymph node or sentinel node (SN).
- Trial name
- SONAR (NCT01734746)
- Testing
- Tracerinjection
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Maastricht University Medical Center
Breast Cancer
Evaluation of Two Techniques for the SLN Detection in BC Patients
The revision of our data shows that since its introduction in our institution (Jules Bordet Institute) in 1998 (until 2010, the year of the last review of cases), 53 patients underwent neoadjuvant therapy before selective…
- Trial name
- NCT02032498
- Testing
- Indocyanine Green
- Where
- Belgium
- Volunteers
- 214 people
- Sponsor
- Jules Bordet Institute
Sentinel Lymph Node, Breast Cancer
Application of Surgical Navigation System in Sentinel Lymph Node of Breast Cancer Research
The purpose of this study is to compare the sentinel lymph node (SLN) detection rate of early breast cancer patients between using Indocyanine green (ICG) and Methylene blue with a novel surgical navigation system.
- Trial name
- NCT02084784
- Testing
- Indocyanine green, methylene blue
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese Academy of Sciences
Breast Cancer
Lymph Node Identification Using Magtrace and Magseed Before Chemotherapy
Magnetic tracer injected before preoperative chemotherapy in breast cancer patients for sentinel lymph node detection. Also, magnetic tracer in combination with magnetic clip for index node identification.
- Trial name
- SentiNeo2 (NCT06104371)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 459 people
- Sponsor
- Vastra Gotaland Region
Germ Cell Tumor of Testis
Sentinel Node Identification Using Gamma and Near-Infrared Imaging in TesticulAr MaLignancies
Testicular seminoma is a malignant tumor with a very high probability of cure. Current treatment approaches provide excellent long-term cancer outcomes.
- Trial name
- SIGNAL (NCT07777887)
- Testing
- Standard treatment: orchiectomy followed by drug therapy and, if necessary, retroperitoneal lymphadenectomy, sentinel lymph node mapping using technetium-99m (Tc-99m) and indocyanine green (ICG) with subsequent orchiectomy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Endometrial Cancer, Sentinel Lymph Node Detection
Indocyanine Green and Near-infrared Fluorescence Imaging to Detect Sentinel Lymph Nodes in Patients With Endometrial Cancer
Patients with endometrial cancer who have planned robotic laparoscopic hysterectomy and full bilateral pelvic and para-aortic lymphadenectomy will receive injections of a fluorescent dye, Indocyanine green (ICG).
- Trial name
- NCT02131558
- Testing
- ICG Dye
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Lahey Clinic
Breast Cancer, Sentinel Node
The Efficacy of Sentimag in Detection of Sentinel Node Biopsy
The aim of this study is to evaluate the Sentimag/Sienna+ System (Sentimag®) in clinical routine practice. On the one hand this allows evaluation of the equivalence of the two techniques.
- Trial name
- SMART (NCT02739425)
- Testing
- Sentimag Device
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Colon Cancer
Sentinel Node in Colon Cancer
More than 20% of patients operated on for colon cancer without node metastasis will develop visceral metastases. The purpose of the study is to determine sentinel lymph nodes with two methods: blue injection and isotopic…
- Trial name
- NCT00411112
- Testing
- blue and isotopic detection of sentinel lymph nodes
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Strasbourg, France
Cancer of the Endometrium
Evaluation of the Fluorescent Green of Indocyanine in the Detection of Sentinel Lymph Node in Endometrial Cancer
Selective lymphadenectomy Sentinel (LSS). This technique is already well established in breast cancer and melanoma and more recently in vulvar and cervical cancer.
- Trial name
- Sentimetre (NCT03024398)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Breast Neoplasms, Breast Diseases
Clinical Evaluation of OSNA Breast Cancer System to Test Sentinel Lymph Nodes From Patients With Breast Cancer
The study will determine the sensitivity, specificity, negative predictive value and positive predictive value of the OSNA Breast Cancer System by comparing its performance to permanent section Hematoxylin and Eosin (H\&E) and…
- Trial name
- NCT01136369
- Testing
- OSNA Breast Cancer System
- Where
- 11 sites in United States
- Volunteers
- 496 people
- Sponsor
- Sysmex America, Inc.
Breast Cancer
A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy.
This prospective, observational study will evaluate the patient-based sentinel lymph node detection rate when using the Infracyanine® (indocyanine green) dye technique in patients undergoing surgery for breast cancer.
- Trial name
- OASIS (NCT06024213)
- Testing
- Sentinel lymph node identification, indocyanine green, methylene blue
- Where
- 6 sites in France
- Volunteers
- 101 people
- Sponsor
- BTG International Inc.
Endometrial Cancer
Hysteroscopic vs. Cervical Injection for Sentinel Node Detection of Endometrial Cancer
Hysteroscopic vs. Cervical Injection for Sentinel Node Detection of Endometrial Cancer: a multicenter prospective randomized study
- Trial name
- SLN_EC (NCT04302714)
- Testing
- Hysteroscopic injection, Cervical injection
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Vulval Cancer, Sentinel Lymph Node Detection
Charcoal Carbon Black Dye Use in Sentinel Lymph Node Mapping in Early Stage Vulvar Cancer
The aim of this study is to investigate the detection rate, sensitivity and specifity of charcoal carbon black dye as a sentinel lymph node tracer in inguinofemoral lymph node(s) in early stage vulvar cancer
- Trial name
- IFLND (NCT06694116)
- Testing
- sentinel lymph node biopsy using carbon dye
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Invasive Breast Cancer
Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions
This is a pilot study to test and characterize the ability of the Smart Goggles system to detect fluorescently labeled sentinel lymph nodes (SLNs).
- Trial name
- NCT02802553
- Testing
- Smart Goggle, Cardio-Green, SPY Elite Imaging system
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Vulva Cancer
SLN Mapping and ICG Dye for Vulvar Cancer
Doctors typically use blue dye to assist in locating and extracting lymph nodes for biopsy. However, this process can prove somewhat challenging for both patients and medical teams due to its need for extensive coordination and…
- Trial name
- NCT06035068
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts Medical Center
Melanoma (Skin)
Interferon Alfa-2b in Treating Patients With Melanoma and Early Lymph Node Metastasis
RATIONALE: Interferon alfa-2b may interfere with the growth of cancer cells. PURPOSE: Randomized phase III trial to study the effectiveness of interferon alfa-2b in treating patients who have melanoma with early lymph node…
- Trial name
- NCT00004196
- Testing
- recombinant interferon alfa, lymphangiography, Observation
- Where
- 4 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Alabama at Birmingham
Ovarian Epithelial Cancer
Sentinel Node Detection With Technetium-99m Albumin Nanocolloid and ICG in Patients With Epithelial Ovarian Cancer
Study to evaluate the diagnostic precision of ICG and 99mTc nanocolloid albumin in sentinel lymph node detection in early ovarian epithelial cancer.
- Trial name
- Melisa-II (NCT05937620)
- Testing
- 99mTC nanocolloid albumin injection, ICG injection
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Endometrial Neoplasms
Sentinel Lymph Node Detection in Endometrial Cancer
In endometrial cancer (EC) pelvic and paraaortic lymphadenectomy is performed only in high risk groups (with approximately 20% of patients having lymph node metastases (LNM)) whereas no lymphadenectomy is recommended in low risk…
- Trial name
- NCT02690259
- Testing
- Sentinel node procedure
- Where
- Sweden
- Volunteers
- 257 people
- Sponsor
- Region Skane
Vulvar Cancer
Indocyanine Green for Detection of Sentinel Lymph Nodes In Comparison to ICG Plus Technetium in the Evaluation of Vulvar Squamous Cell Carcinoma
The aim of this study is to confirm prospectively if the use of near infrared-indocyanine green (NIR-ICG) alone offers similar accuracy and sensitivity to the gold standard dual technique for sentinel lymph node detection in…
- Trial name
- IGNITE-V (NCT06039111)
- Testing
- ICG alone
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation