Clinical trials: Sentinel Node
Breast Cancer
Fluorescein for Sentinel Lymph Node Biopsy (SLNB) in Breast Cancer
The study goal is to develop a new method of intraoperative lymphatic mapping with fluorescent contrast agents to improve the outcome of therapeutic breast cancer surgery.
- Trial name
- NCT01614184
- Testing
- Fluorescein
- Sponsor
- University of Utah
Breast Cancer, Clinically Assessed Negative Axillary Lymph Nodes
Omission of SLNB in CN0 Early Breast Cancer
The OMSLNB trial adopts a prospective, single-arm, non-inferiority, phase-II, open-label study design. Patients with unilateral invasive breast cancer （tumor ≤3cm） and assessed as cN0 will be eligible for inclusion, enrolled…
- Conditions
- Breast Cancer, Clinically Assessed Negative Axillary Lymph Nodes, Sentinel Lymph Node
- Trial name
- NCT05935150
- Testing
- Omit SLNB
- Where
- China
- Volunteers
- 311 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Lung Cancer
Pilot Study of Novel Fluorescence Endoscopic Device for Sentinel Lymph Node Mapping in Lung Cancer
This research study is studying a new imaging method that will show lymph nodes in the lung during lung cancer surgery. The name of the study intervention involved in this study is: -- The combination of the FluoSCOPE device and…
- Trial name
- NCT02423148
- Testing
- Indocyanine green (ICG), FluoSCOPE
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer Invasive
Precision Regional Node Irradiation for Sentinel Node-positive Breast Cancer
Axillary lymph node dissection has long been regarded as standard if treatment of the axilla is indicated for patients with a positive sentinel node.
- Trial name
- NCT06583655
- Testing
- SLND(clinical low risk), SLND(clinical high risk, genomic low risk), SLND alone ,clinical high risk and genomic high risk group
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Ruijin Hospital
Sentinel Lymph Node Biopsy, Breast Cancer
Tilmanocept vs Sulfur Colloid in Sentinel Lymph Node Biopsy
A randomized controlled double-blinded study comparing the intraoperative injection of lymphatic mapping agents Tc 99m tilmanocept to Tc 99m filtered sulfur colloid in breast cancer patients undergoing breast conservation and…
- Trial name
- NCT03199560
- Testing
- Tc 99m tilmanocept, Tc 99m filtered sulfur colloid
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Memorial Health University Medical Center
Breast Cancer
Sentinel Lymph Node Biopsy to Assess Axillary Lymph Nodes in Women With Stage I or Stage II Breast Cancer
RATIONALE: Diagnostic procedures such as sentinel lymph node biopsy may improve the ability to detect breast cancer and determine the extent of disease.
- Trial name
- NCT00005821
- Testing
- patent blue V dye, conventional surgery, lymphangiography
- Where
- 4 sites in United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Cancer, Sentinel Node
Lymphatic Mapping After Previous Breast Surgery
Rationale: Like in primary breast cancer, prognosis in recurrent breast cancer is correlated with regional lymph node status. Therefore, axillary staging may be warranted in patients with recurrent disease and intact axillary…
- Trial name
- LABS (NCT01164748)
- Testing
- Lymphoscintigraphy
- Where
- Netherlands
- Sponsor
- Catharina Ziekenhuis Eindhoven
Colon Cancer
The Significance of Sentinel Node Analysis in Colon Cancer
This study is for the patient with colon cancer, who is going to have colon cancer surgery. The purpose of this research study is to examine a specific lymph node, called the sentinel node.
- Trial name
- NCT00419978
- Testing
- Colectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Legacy Health System
Sentinel Lymph Node, Endometrial Cancer
Sentinel Lymph Node in Early-Stage Endometrium Cancer
The aim of this prospective study is to investigate whether the detection rate of sentinel lymph node (SLN) with double tracer injected at two different sites may be increased compared to the standard use of a single tracer with…
- Trial name
- NCT06163963
- Testing
- Sentinel Lymph Node Mapping With Double Tracer and Double Injection Sites in Early-Stage Endometrium Cancer, charcoal injection to uterus to map sentinel lymph nodes
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Colorectal Cancer
Lymphatic Mapping, Sentinel Lymph Node Analysis, and Blood Tests in Detecting and Predicting Early Micrometastases in Patients With Colorectal Cancer
RATIONALE: Diagnostic procedures, such as lymph node mapping during surgery and sentinel lymph node biopsy, may help doctors find micrometastases and predict cancer recurrence.
- Trial name
- NCT00625625
- Testing
- isosulfan blue, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Volunteers
- 225 people
- Sponsor
- Saint John's Cancer Institute
Breast Cancer, Sentinel Node
The Efficacy of Sentimag in Detection of Sentinel Node Biopsy
The aim of this study is to evaluate the Sentimag/Sienna+ System (Sentimag®) in clinical routine practice. On the one hand this allows evaluation of the equivalence of the two techniques.
- Trial name
- SMART (NCT02739425)
- Testing
- Sentimag Device
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Ovarian Cancer, Sentinel Lymph Node
Mapping Sentinel Lymph Node in Initial Stages of Ovarian Cancer
Epithelial ovarian cancer (EOC) diagnosed in the initial stage (stage I-II) require complete staging surgery to histologically assess the possible existence of peritoneal or lymph node disease.
- Trial name
- MELISA (NCT05184140)
- Testing
- Sentinel node detection
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Lymphedema, Lymphedema Arm
Reduction of Arm Volume and Improvement in Lymphedema Via Surgery
This clinical trial aims to evaluate the effectiveness of lymphatic microsurgical treatments in reducing limb volume in female patients with breast cancer-related lymphedema (BCRL).
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Arm, Lymphedema of Upper Limb
- Trial name
- REFRESH (NCT06606145)
- Testing
- Lymphovenous Anastomosis, Vascularized Lymph Node Transfer, Combined Lymphovenous Anastomosis and Vascularized Lymph Node Transfer
- Where
- Belgium
- Volunteers
- 179 people
- Sponsor
- Universitair Ziekenhuis Brussel
Breast Cancer (Triple Negative Breast Cancer (TNBC)), Breast Cancer
Exemption of SLNB After Neoadjuvant Therapy for Triple-negative and Her2-positive Breast Cancer
The neoadjuvant system therapy (NAST) can significantly increase the pathological complete response (pCR) rate for patients with triple-negative (TNBC) and HER2-positive breast cancer.
- Trial name
- NCT07498400
- Testing
- Exemption of SLNB
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Xijing Hospital
Multiple Myeloma, Breast Cancer
Efficacy of Gamma Camera Used Intraoperatively for ID of Sentinel Lymph Nodes w/ Lymphoscintigraphy
This study evaluates the ability of a prototype intraoperative handheld gamma camera (pIHGC) to image (detect) sentinel lymph nodes (SLNs) in melanoma and breast cancer during surgical excision, as compared to standard of care…
- Trial name
- NCT01314963
- Testing
- Prototype intraoperative handheld gamma camera (pIHGC), Lymphoscintigraphy with intraoperative gamma probes (GP), radioactive Tc99M
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Melanoma, Head and Neck Cancer
Evaluation of Intraoperative Usage of Sentinella in Detecting Sentinel Lymph Nodes
The aim of this study is to investigate whether the Sentinella camera improves intraoperative detection and removal of sentinel lymph nodes (SLNs) when used in conjunction with standard detection methods.
- Conditions
- Melanoma, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT02416336
- Testing
- Sentinella Intraoperative imaging protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oncovision Inc
Melanoma (Skin)
MR Lymphography and Magnetic Sentinel Lymph Node Biopsy in Melanoma Patients
The sentinel lymph nodes (SLNs) are the first lymph nodes (LNs) to drain the tumor site and therefore the first LNs to bare metastases. Hence the importance to investigate these LNs for the best treatment strategy.
- Trial name
- MelaDiff (NCT05569707)
- Testing
- Magnetic sentinel lymph node biopsy by use of Magtrace®, in combination with SentiMag® and DiffMag
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University of Twente
Gastric Cancer, Sentinel Lymph Node
Fluorescence Image-Guided Lymphadenectomy in Robotic Gastrectomy
Gastric cancer is a worldwide challenge due to its spread, even epidemic in some areas, and the high mortality rates. Lymphadenectomy is considered the fundamental step during radical gastrectomy.
- Trial name
- IG-MIG (NCT03931044)
- Testing
- Image-Guided Robotic Gastrectomy
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- International Study Group on Minimally Invasive Surgery for Gastric Cancer
Ovarian Neoplasms, Sentinel Node
Sentinel Node Detection in Ovarian Cancer
Recently the investigators have shown that the SN procedure performed through the injection of tracers into the ovarian ligaments is feasible and promising in patients with clinical early stage ovarian cancer (OC).
- Trial name
- SONAR-2 (NCT02540551)
- Testing
- Injection of radioactive tracer combined with Patent Blue
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Maastricht University Medical Center
Invasive Breast Cancer
Axillary Lymph Node Status After Completion of Preoperative Neoadjuvant Systemic Chemotherapy in Patients
The purpose of the present proposed clinical trial will be to assess the utility of SLN mapping and biopsy for predicting the final axillary status after completion of preoperative neoadjuvant systemic chemotherapy in patients…
- Trial name
- NCT00507611
- Testing
- Sentinel node mapping
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stephen Povoski