Clinical trials: Sentinel Node
Cervical Cancer
TMVP1-ICG Mapping in Laparoscopic SLN Detection in Cervical Cancer
Sentinel lymph node (SLN) mapping is an acceptable surgical strategy determine whether to perform radical lymphadenectomy in patients with early-stage cervical cancer.
- Trial name
- NCT03320772
- Testing
- TMVP1-ICG, ICG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
Endometrial Neoplasms
Sentinel Node and Endometrial Cancer
The purpose of this study is to investigate the relevance of sentinel node in endometrial cancer. Sentinel node is thought to reflect the status of lymph node.
- Trial name
- Senti-Endo (NCT00987051)
- Testing
- Detection of sentinel node
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Melanoma
Multicenter Selective Lymphadenectomy Trial II (MSLT-II)
Subjects must be diagnosed with melanoma. All subjects receive sentinel lymphadenectomy. If the subject is sentinel node positive and meets study requirements, the subject is randomized to receive either (1) completion…
- Trial name
- NCT00297895
- Testing
- Completion Lymphadenectomy, Monitoring with nodal ultrasound
- Where
- 63 sites in United States, Australia and 10 more
- Volunteers
- 1,939 people
- Sponsor
- Saint John's Cancer Institute
Colon Cancer, Colon Adenocarcinoma
Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma
The aim of this study is to reduce the need for colectomy and its' associated morbidity and mortality in patients with pT1-2 colon carcinoma after endoscopic resection and an estimated lymph node metastasis (LNM) risk of >15%, or…
- Conditions
- Colon Cancer, Colon Adenocarcinoma, Sentinel Lymph Node, Sentinel Lymph Node Biopsy
- Trial name
- SENTRY (NCT06652672)
- Testing
- Organ-sparing surgery, Standard of care segmental resection
- Where
- Netherlands
- Volunteers
- 341 people
- Sponsor
- Meander Medical Center
Endometrial Cancer
Concurrent Use Lymphoseek & Indocyanine Green in Sentinel Lymph Node Detection in Endometrial Cancer
The goal of this study is to (i) improve detection of sentinel nodes and (ii) reduce additional surgical dissection that is needed in case a sentinel lymph node cannot be detected.
- Trial name
- NCT04511026
- Testing
- Lymphoseek, Single Photon Emission Computed Tomography (SPECT), Indocyanine Green (ICG)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Breast Cancer
Safety and Efficacy of Omission of Sentinel Node Biopsy in Patients With Estrogen-Positive Breast Cancer Over Age 65
This study will examine the outcomes of lumpectomy, surgery to remove a tumor, without sentinel node biopsy (SNB) for women at least 65 years of age with clinically node-negative breast cancer.
- Trial name
- NCT02564848
- Testing
- Lumpectomy without sentinel node biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Breast Cancer
Sentinel lympH Node Biopsy With Indocyanine Green in Breast Cancer After NEoadjuvant Chemotherapy (SHINE)
This is a prospective, open-label, within-patient clinical trial to determine the accuracy of Indocyanine green (ICG) guided sentinel lymph node biopsy (SLNB) compared to the standard dual-tracer SLNB in breast cancer patients…
- Trial name
- SHINE (NCT06085274)
- Testing
- ICG guided sentinel lymph node biopsy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Prostatic Neoplasms
Sentinel Lymph Node Detection in Prostate Surgery by Laparoscopy
In this study the investigators want to determine if the detection of lymph node is applicable in prostatectomy by laparoscopy.
- Trial name
- NCT01296217
- Testing
- lymph nod detection
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre René Gauducheau
Endometrial Cancer
A Prospective Study Comparing Three Injection Sites to Detect Sentinel Lymph Nodes in Endometrial Cancer
Uterine cancer is the most common gynecologic malignancy in developed countries. Adenocarcinoma of the endometrium is the most common histologic type of uterine cancer.
- Trial name
- SENNAN (NCT04577950)
- Testing
- Lymphatic drainage of endometrial cancer
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Uterine Cervical Neoplasms, Uterine Neoplasms
Sentinel Node Mapping in Women With Cervical and Endometrial Cancer
This study aims to evaluate the effect of SLN mapping on the incidence and severity of lymphedema in women with early stage cervical and endometrial cancer.
- Trial name
- SENTIREC I (NCT02825355)
- Where
- 3 sites in Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Sentinel Lymph Node, Breast Cancer
A Clinical Feasibility Study of a Photoacoustic Finder
Determining the prognosis of breast cancer relies significantly on axillary staging by sentinel lymph node biopsy (SLNb). The SLNb is generally performed using radioisotopes, blue dyes, or both to improve the false negative rate.
- Trial name
- NCT06412211
- Testing
- Photoacoustic finder
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Seoul St. Mary's Hospital
Breast Cancer
Functional Anatomical Examination of Axillary Sentinel Lymph Node Drainage in the Axillary Subregions in Early Breast Cancer
Regional lymph node status is the most important prognostic factor for disease-free and overall survival in breast cancer. Accurate nodal staging can be achieved only by surgery.
- Trial name
- NCT01804309
- Testing
- Sentinel lymph node biopsy (SLNB)
- Where
- Hungary
- Volunteers
- 350 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer, Axillary Lymph Node Metastasis
A Prospective Multicenter Study of the TuFEst-LN Model for Axillary Lymph Node Status Assessment in Breast Cancer
Through the research of this project, we expect to validate the clinical utility of the TuFEst-LN model in assessing axillary lymph node status in breast cancer patients.
- Trial name
- PRO-TuFEst-LN (NCT07304934)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer
SLNB Combined With WLNB for Axillary De-escalation in Breast Cancer Patients With Abnormal Axillary Nodes
This prospective observational diagnostic study aims to evaluate the feasibility of using sentinel lymph node biopsy combined with wire localized lymph node biopsy (SLNB+WLNB) to identify breast cancer patients with 1-2…
- Trial name
- NCT07791771
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking University Cancer Hospital & Institute
Stage IB Melanoma, Stage IIA Melanoma
Sargramostim or Hypertonic Saline Before Sentinel Lymph Node Biopsy in Treating Patients With Stage IB-II Melanoma
This randomized phase III trial studies sargramostim before sentinel lymph node biopsy to see how well it works compared to hypertonic saline before sentinel lymph node biopsy in treating patients with melanoma.
- Conditions
- Stage IB Melanoma, Stage IIA Melanoma, Stage IIB Melanoma, Stage IIC Melanoma
- Trial name
- NCT01826864
- Testing
- sargramostim, sentinel lymph node biopsy, laboratory biomarker analysis
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Ductal Carcinoma in Situ
Evaluation of Novel Iron-based Lymphatic Mapping Agent, Magtrace, for Delayed Sentinel Lymph Node Biopsy (SLNB) in Ductal Carcinoma In-Situ (DCIS)
The standard surgical approach for all patients undergoing mastectomy for the treatment of non-invasive, ductal carcinoma in situ (DCIS) is to perform axillary lymph node staging through use of a traditional sentinel lymph node…
- Trial name
- NCT06868238
- Testing
- Magtrace
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Breast Cancer, Sentinel Lymph Node
No Axillary sUrgical Treatment In Clinically Lymph Node Negative Patients After UltraSonography
NAUTILUS study is a prospective, multicenter, RCT. Clinically T1,T2, node negative BCS candidates with no evidence of metastases in AUS are 1:1 randomized into no SLNB group and SLNB group.
- Trial name
- NCT04303715
- Testing
- No SLNB, SLNB
- Where
- South Korea
- Volunteers
- 1,734 people
- Sponsor
- Seoul National University Hospital
Colon Cancer
The Significance of Sentinel Node Analysis in Colon Cancer
This study is for the patient with colon cancer, who is going to have colon cancer surgery. The purpose of this research study is to examine a specific lymph node, called the sentinel node.
- Trial name
- NCT00419978
- Testing
- Colectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Legacy Health System
Cutaneous Melanoma, Melanoma
Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma
This pilot phase I trial studies how well sonazoid-enhanced ultrasound works in detecting sentinel lymph node in patients with cutaneous melanoma.
- Trial name
- NCT02968680
- Testing
- Sentinel Lymph Node Biopsy, Ultrasonography, Sonazoid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Southern California
Endometrial Cancer, Endometrial Neoplasms
[SENTRY] Tailoring Postoperative Management Through Sentinel Lymph Node Biopsy in Low- and Intermediate-Risk Endometrial Cancer
While total hysterectomy without lymph node staging is standard for low- and intermediate-risk endometrial cancer, certain histopathologic factors can necessitate additional interventions.
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Endometrial Adenocarcinoma, Endometrial Cancer Stage I
- Trial name
- SENTRY (NCT04972682)
- Testing
- Laparoscopic total hysterectomy with bilateral salpingo-oophorectomy and sentinel lymph node biopsy
- Where
- Russia
- Volunteers
- 102 people
- Sponsor
- Moscow City Oncology Hospital No. 62