Clinical trials: Sentinel Nodes
Breast Cancer, Locally Recurrent Breast Cancer
Photo-medicine-Guided Dual Approach for Reoperation of Sentinel Lymph Nodes in Locally Recurrent Breast Cancer Patients
Sentinel lymph node biopsy (SLNB) is essential for staging and treatment planning in early breast cancer patients. As a less invasive procedure, it has replaced axillary lymph node dissection (ALND) by reducing complications and…
- Conditions
- Breast Cancer, Locally Recurrent Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Reoperation
- Trial name
- NCT06780748
- Testing
- Identification rate of sentinel lymph node
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Parathyroid Adenoma, Thyroid Adenoma
Evaluation of a New CZT System
The purpose of the study is to check if the new CZT system has an advantage in detection of small osseous processes, thyroid adenomas, parathyroid adenomas and detection of sentinel node, in comparison with the techniques in use.
- Trial name
- NCT01084356
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Breast Cancer
Premarking of Axillary Nodes Before Start of Neoadjuvant Chemotherapy Using Magnetic Approach
Breast cancer is one of the commonest types of cancers in females. Treatments include surgery followed by anti-estrogen therapy, radiotherapy and chemotherapy.
- Trial name
- SENTINEO (NCT05625698)
- Testing
- MagTrace only, MagTrace and Magseed
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Breast Cancer
Preoperative Localization of Sentinel Lymph Node in Breast Cancer Patients By Novel Computed Tomography-Lymphography Guided Technique
A question is raised about the possibility of accurate localization of the SLN (sentinel lymph node) detected by CTLG (Computed Tomography Lymphography) which offers a detection rate of 100% in many studies In Oncology center…
- Trial name
- NCT03442543
- Testing
- preoperative localization of SLN detected by CTLG by either methods
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Thyroid Neoplasm
Lateral Neck Sentinel Lymph Node Biopsy(LSLNB)in PTC
Objective: To investigate the incidence of lateral neck node occult metastasis and to show the usefulness of sentinel lymph node biopsy (SLNB) in the detection of lateral neck node metastasis in thyroid carcinoma, the…
- Trial name
- LSLNB (NCT01137097)
- Testing
- Lateral sentinel lymph node biopsy
- Where
- South Korea
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Carcinoma
Extent of Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Occult lymph node metastasis is common in micro papillary thyroid cancer. However, the role of lymph node dissection in the treatment of microPTC remains controversial.
- Trial name
- NCT01149161
- Testing
- Routine central neck dissection
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Breast Cancer
Sentinel Lymph Node Biopsy With Hybrid Technique in Breast Cancer
Sentinel lymph node (SLN) biopsy is the gold standard method to stage axilla in breast cancer. The aim of the study is to compare the efficiency of various methods to identify SLN is breast cancer patients.
- Trial name
- NCT04274946
- Testing
- Sentinel lymph node biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Endometrial Cancer, Lymph Node Metastasis
Staging Endometrial caNcer Based on molEcular ClAssification
The SENECA study tries to evaluate the rate of lymph node involvement depending on the molecular subgroup in early-stage endometrial cancer (I/II) patients undergoing surgery as part of their treatment.
- Conditions
- Endometrial Cancer, Lymph Node Metastasis, Sentinel Lymph Node
- Trial name
- NCT05707312
- Where
- Spain
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Breast Neoplasm
The Multi-center Validation Study of Internal Mammary Lymph Biopsy With Modified Injection Technique in Breast Cancer Patients
In addition to axillary lymph node (ALN), internal mammary lymph node (IMLN) chain is also the first-echelon nodal drainage site for metastasis and it provides important prognostic information in breast cancer patients.
- Trial name
- NCT03024463
- Testing
- IM-SLNB and IMLN dissection
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer
Contrast Ultrasound Detection of Sentinel Lymph Nodes
This is a two part, open label, non-randomized trial of women with a breast cancer diagnosis scheduled for excisional surgery and sentinel lymph node (SLN) evaluation.
- Trial name
- NCT02652923
- Testing
- Sonazoid; Perflubutane for Injection
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Breast Neoplasms
Study Assessing The Interest of Indocyanine Green Fluorescence Imaging With Radioisotope Method For Sentinel Lymph Node Biopsy in Patients With Breast Cancer
The sentinel node has a fundamental role in the management of early breast cancer. Currently, the double detection of blue and radioisotope is recommended.
- Trial name
- FLUOTECH (NCT02279108)
- Testing
- indocyanine green, isotope
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sentinel Lymph Node Biopsy, Neoadjuvant Therapy
Clinical Application of Multi-modal Sentinel Lymph Node Staining Method in Breast Cancer Patients After Neoadjuvant Chemotherapy
This clinical trial aimed to confirm the effectiveness of sentinel lymph node surgery by determining the lymph node identification rate using multimodal sentinel lymph node marker methods in patients with advanced breast cancer…
- Conditions
- Sentinel Lymph Node Biopsy, Neoadjuvant Therapy, Breast Neoplasm
- Trial name
- NCT06212440
- Testing
- Radioactive Isotope (RI) Mapping, Indocyanine Green Fluorescence (ICG-F) Mapping, Vital Dye Mapping
- Where
- 2 sites in South Korea
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Lymph Node Cancer Metastatic
Axillary Reverse Mapping in Breast Cancer
The axillary mapping reverse (ARM) consists in differentiating the upper limb lymph nodes from the breast ones in order to preserve them and reduce the possibility of lymphedema.
- Trial name
- ARM (NCT05040685)
- Testing
- Axillary mapping reverse
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Sentinel Lymph Node Biopsy, Mastectomy, Subcutaneous
SLNB After Nipple Sparing Mastectomy
Sentinel Lymph Node Biopsy (SLNB) after nipple sparing mastectomy (NSM) is controversial. This study aims to investigate feasibility of SLNB with radioisotope method.
- Trial name
- NCT04140188
- Testing
- Senti-Scint (99mTc- pertechnetate combined with human albumin)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Sentinel Lymph Node
SENTINEL LYMPH NODE BIOPSY AFTER NEOADJUVANT CHEMOTHERAPY
Omitting axilary lymph node dissection (ALND) following SLNB with residual cancer in patients with locally advanced disease after neoadjuvan chemotherapy (NAC) is still controversial.
- Trial name
- NEOSENTITURK (NCT04250129)
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Federation of Breast Diseases Societies
Breast Cancer
Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)
The purpose of this study is to develope a one-step procedure to perform a biopsy of axillary lymph nodes on the same side as the breast tumor in women diagnosed with breast cancer.
- Trial name
- NCT00784849
- Testing
- Methylene blue
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Ovarian Cancer, Sentinel Lymph Node
Mapping Sentinel Lymph Node in Initial Stages of Ovarian Cancer
Epithelial ovarian cancer (EOC) diagnosed in the initial stage (stage I-II) require complete staging surgery to histologically assess the possible existence of peritoneal or lymph node disease.
- Trial name
- MELISA (NCT05184140)
- Testing
- Sentinel node detection
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer
Validity of Sentinel Lymphnode Biopsy After Neoadjuvant Chemotherapy Cancer Patients With Radiologically Positive Axillary Lymph Nodes
Sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) is currently debatable. It is possible that the tumor response to chemotherapy may alter the lymphatic drainage thus causing lower SLN identification rate and…
- Trial name
- VSNBNAC (NCT01622478)
- Testing
- Sentinel lymph node biopsy, Neoadjuvant chemotherapy, complete axillary lymph node dissection
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Early-stage Breast Cancer
Sentinel Lymph Node Identification in Patients With Breast Cancer Using SPECT/CT
Role of SPECT/CT in detection of sentinel lymph node in patients with breast cancer that is in early stage with small mass with no nodal or distant metastasis using radioactive material nannocolloid that can change surgical…
- Trial name
- NCT03468374
- Testing
- lymphoscintigraphy, Single Photon Emission Tomography
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Assiut University
Genetic Predisposition, BRCA Mutation
Frequency of Occult Breast Cancer After Prophylactic Mastectomy Among High-Penetrance Breast Cancer Gene Positives
The role of Sentinel Lymph Node Biopsy(SLNB) among mutation-negative BC patients is well established; however, we are lacking data to assess the role of sentinel lymph node biopsy for patients who are undergoing surgery for…
- Conditions
- Genetic Predisposition, BRCA Mutation, Breast Cancer, Occult Cancer
- Trial name
- OBC-PM (NCT05771454)
- Testing
- Histopathological confirmation
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan