Clinical trials: Sentinel Nodes
Vaginal Cancer
Lymphoscintigraphy in Patients With Vaginal Cancer
Primary Objectives: 1. Determine the feasibility of using pretreatment lymphoscintigraphy to identify the sentinel lymph node(s) in patients with vaginal cancer dispositioned to receive radiation therapy. 2.
- Trial name
- NCT00528034
- Testing
- Lymphoscintigraphy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus
Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.
- Conditions
- Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling, Prognosis
- Trial name
- NCT04276532
- Testing
- sentinel lymph node sampling (SLN), pelvic lymphonodectomy (PLN)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Xiaojun Chen
Breast Cancer
Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer
To compare the kinetics and efficacy of two functionally different diagnostic agents, Lymphoseek (CD206 receptor targeted) and 99mTc-Sulfur Colloid (SC) (Sulfur Colloid non-specific mapping agent) in intraoperative lymphatic…
- Trial name
- Lymphoseek (NCT02287675)
- Testing
- Lymphoseek, Sulfur Colloid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kettering Health Network
Breast Cancer, Cancer of Breast
Fluorescence Imaging in Sentinel Lymph Node Biopsy for Breast Cancer and Melanoma
The NIR light source of our device is based on light-emitting diodes (LEDs), which can deliver sufficient light to biological tissues and induce fluorescence emission to meet the needs of the planned clinical studies.
- Conditions
- Breast Cancer, Cancer of Breast, Cancer of the Breast, Melanoma
- Trial name
- NCT02316795
- Testing
- Sentinel lymph node biopsy, Goggle-based device with light-emitting diodes (LED), Indocynanine Green
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Injection Methods in Finding the Sentinel Lymph Node During Lymphatic Mapping and Sentinel Lymph Node Biopsy in Patients With Invasive Breast Cancer
RATIONALE: Diagnostic procedures, such as lymphoscintigraphy using an injection under the nipple or near the tumor, may help doctors find out how far the disease has spread.
- Trial name
- NCT00438477
- Testing
- Isosulfan Blue, Lymphangiography, Technetium Tc 99m sulfur colloid
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Cancer, Sentinel Lymph Node
Mapping Sentinel Lymph Node in Initial Stages of Ovarian Cancer
Epithelial ovarian cancer (EOC) diagnosed in the initial stage (stage I-II) require complete staging surgery to histologically assess the possible existence of peritoneal or lymph node disease.
- Trial name
- MELISA (NCT05184140)
- Testing
- Sentinel node detection
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Ovarian Cancer, Sentinel Lymph Node
Sentinel Lymph Node Assessment in Ovarian Cancer (TRSGO-SLN-OO5)
The aim of the study to evaluate the feasibility and accuracy of sentinel lymph node technique in ovarian cancer.
- Trial name
- NCT04714931
- Testing
- Sentinel lymph node detection
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Sentinel Lymph Node Biopsy
Sentinel Node Detection in Cervical Cancer
Evaluation of sensitivity of Sentinel lymph nodes for detecting nodal metastases in cervical cancer
- Trial name
- SLNcxca (NCT03680833)
- Testing
- Sentinel node detection in cervical cancer
- Where
- Sweden
- Volunteers
- 226 people
- Sponsor
- Region Skane
Breast Cancer
The Memorial Sloan-Kettering Cancer Center (MSKCC
The purpose of this study is to prospectively evaluate the combined use of the MSKCC nomogram (Memorial Sloan-Kettering Cancer Center) and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low…
- Trial name
- NOTEGS (NCT01509963)
- Testing
- no intervention : measure of score
- Where
- France
- Volunteers
- 3,194 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer of the Endometrium
Evaluation of the Fluorescent Green of Indocyanine in the Detection of Sentinel Lymph Node in Endometrial Cancer
Selective lymphadenectomy Sentinel (LSS). This technique is already well established in breast cancer and melanoma and more recently in vulvar and cervical cancer.
- Trial name
- Sentimetre (NCT03024398)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Breast Cancer, Triple Negative Breast Cancer
Avoiding Sentinel Lymph Node Biopsy in Breast Cancer Patients After Neoadjuvant Chemotherapy
This study evaluates whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve a radiological complete response on MRI after neoadjuvant systemic therapy
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, HER2-positive Breast Cancer, Sentinel Lymph Node
- Trial name
- ASICS (NCT04225858)
- Testing
- Omission of sentinel lymph node biopsy
- Volunteers
- 340 people
- Sponsor
- The Netherlands Cancer Institute
Germ Cell Tumor, Seminoma
Robot-assisted ICG-guided Sentinel Node Biopsy in Testicular Cancer
Robot-assisted image-guided sentinel lymph node biopsy (RAISN) in testicular cancer is a novel technique that has not been widely investigated yet.
- Conditions
- Germ Cell Tumor, Seminoma, Nonseminomatous Germ Cell Tumor
- Trial name
- RAISN (NCT06133543)
- Testing
- Robot-assisted ICG-guided sentinel lymph node biopsy
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Colorectal Neoplasms, Colon Neoplasm
Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Intravenous Bevacizumab-800CW
This prospective study aims to assess the safety and feasibility of lymph node identification using bevacizumab-800CW in patients with cT1-3N0-2 tumours, using intravenous administration.
- Conditions
- Colorectal Neoplasms, Colon Neoplasm, Sentinel Lymph Node, Fluorescence
- Trial name
- IBIZA-2 (NCT05497726)
- Testing
- Sentinel lymph node detection using intravenous bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Meander Medical Center
Endometrial Cancer
A Prospective Study Comparing Three Injection Sites to Detect Sentinel Lymph Nodes in Endometrial Cancer
Uterine cancer is the most common gynecologic malignancy in developed countries. Adenocarcinoma of the endometrium is the most common histologic type of uterine cancer.
- Trial name
- SENNAN (NCT04577950)
- Testing
- Lymphatic drainage of endometrial cancer
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Breast Cancer Invasive
Precision Regional Node Irradiation for Sentinel Node-positive Breast Cancer
Axillary lymph node dissection has long been regarded as standard if treatment of the axilla is indicated for patients with a positive sentinel node.
- Trial name
- NCT06583655
- Testing
- SLND(clinical low risk), SLND(clinical high risk, genomic low risk), SLND alone ,clinical high risk and genomic high risk group
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Ruijin Hospital
BREAST CANCER
IDENTIFICATION OF SENTINEL NODE(S) IN BREAST CANCER
The study is based on the identification of sentinel node(s) by SENTIMAG / SIENNA + in addition to the usual method (blue and /or radioactive product). This is a feasibility study
- Trial name
- SENTIMAG (NCT01790399)
- Testing
- Excision of sentinel node(s)
- Where
- 4 sites in France
- Volunteers
- 115 people
- Sponsor
- Centre Oscar Lambret
Endometrial Cancer
Individualised Endometrial Cancer Risk Stratification by Bayesian Prediction Model (ENDORISK), Optimizing Clinical Implementation
Rationale: Preoperative identification of patients at risk for lymph node metastasis (LNM) is challenging in endometrial cancer (EC).
- Trial name
- ENDORISK-I (NCT07200466)
- Testing
- ENDORISK personalized risk assesment for lymph node metastases in endometrial cancer.
- Where
- 14 sites in Netherlands
- Volunteers
- 735 people
- Sponsor
- Radboud University Medical Center
Breast Cancer Female, Pain, Postoperative
Effects of Bromelain and Boswellia Serrata Casperome With Centella Asiatica and Vitamins on Edema, Paresthesia and Postoperative Pain After Quadrantectomy With or Without Sentinel Lymph Node Biopsy.
Aim: to investigate the effects of dietary supplements on postoperative edema and pain in patients undergoing quadrantectomy for breast cancer.
- Trial name
- NCT04669119
- Testing
- Bromelain/Boswellia Serrata Casperome, Centella Asiatica/Vitamins
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Bari Aldo Moro
Breast Cancer, Sentinel Lymph Node
Trop2-targeting NIR-II Molecular Probe for Breast Cancer Precise Surgery
Positive surgical margins are closely associated with local recurrence in breast-conserving surgery (BCS). Meanwhile, accurately assessing sentinel lymph node (SLN) metastasis is crucial for determining the extent of axillary…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Margins of Excision
- Trial name
- NIR-II (NCT06713681)
- Testing
- TTP-ICG incubation solution
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Yunnan Cancer Hospital
Vulva Cancer, Sentinel Lymph Node
Sentinel Node Extended in Squamous Cell Vulvar Cancer
The aim of this study is to investigate the feasibility of sentinel node biopsy in patients with squamous cell vulvar cancer, currently not regarded suitable for the sentinel node technique, i.e.
- Trial name
- SNEX (NCT04147780)
- Testing
- Sentinel node biopsy
- Where
- 4 sites in Sweden
- Volunteers
- 64 people
- Sponsor
- Diana Zach