Clinical trials: Sepsis, completed
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Hypotension
Efficacy Study of a Facemask Device to Treat Hypotension
The purpose of this study is to determine if the impedance threshold device (ITD) attached to a facemask can increase blood pressure in patients who present to the emergency department with hypotension secondary to hypovolemia.
- Trial name
- NCT00256724
- Testing
- Impedance Threshold Device
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Advanced Circulatory Systems
Fungemia, Mycoses
Voriconazole as Prophylaxis for Liver Transplant Recipients
The study aims to determine if voriconazole prevents invasive fungal infections in liver transplant recipients. Endpoints would be: occurrence of invasive fungal infection and fungal colonization.
- Trial name
- NCT00177788
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Pittsburgh
Bloodstream Infection, Sepsis Bacterial
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes
Bacterial blood stream infections are common and life-threatening. Bloodstream infections have historically been identified using blood cultures, which often take 24-72 hours to result and are imperfectly sensitive.
- Conditions
- Bloodstream Infection, Sepsis Bacterial, MRSA Bacteremia, Vancomycin
- Trial name
- NCT06069206
- Testing
- T2Bacteria® Panel (direct-from-blood testing), Usual Care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Fungal Infection
Fluconazole Pharmacokinetics in Infants
The purpose of this study is to determine the pharmacokinetics of fluconazole in infants and evaluate the dose exposure relationship of current fluconazole dosing in infants who are receiving fluconazole for the prevention or…
- Trial name
- NCT00514358
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital of Philadelphia
Sepsis, Bleeding Disorder
Role of Thromboelastography in Septic Shock
Coagulation dysfunction is frequent in septic patients and it is associated with an increase risk of mortality. During sepsis platelets number usually decreases and their function is reduced and this mechanism is sustained by an…
- Trial name
- NCT03095625
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Turin, Italy
Puerperal Sepsis
Prophylactic Intrapartum Antibiotics and Immunological Markers for Postpartum Morbidity in HIV Positive Women
Postpartum infections are among the leading causes of maternal mortality world-wide, particularly in under-resourced countries. Available data suggests that HIV infected women are at greater risk of postpartum complications than…
- Trial name
- NCT00343317
- Where
- South Africa
- Volunteers
- 1,372 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Acute Kidney Injury Due to Sepsis
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)
The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting…
- Trial name
- CLEAR-AKI (NCT05996835)
- Testing
- TIN816 70 mg lyophilisate powder
- Where
- 79 sites in United States, Argentina and 15 more
- Volunteers
- 316 people
- Sponsor
- Novartis Pharmaceuticals
Candidemia
Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia
A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia.
- Trial name
- HDM-FUN Cand (NCT04979052)
- Testing
- Interferon Gamma-1B
- Where
- 6 sites in United States, Germany and 4 more
- Volunteers
- 65 people
- Sponsor
- Radboud University Medical Center
Postpartum Period, Sepsis
Correlation of Survival in Puerperae by Electrical Impedance Tomography
Introduction: Electrical Impedance Tomography (TIE) consists of an equipment that enables the visualization / quantification in real time of the regional distribution of ventilation and pulmonary perfusion, as well as of…
- Conditions
- Postpartum Period, Sepsis, Respiratory Distress Syndrome,Adult, HELLP Syndrome
- Trial name
- COSIPBEIT (NCT03715647)
- Testing
- Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult
- Volunteers
- 30 people
- Sponsor
- Amazon University
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Sepsis, Septic Shock
Safety and Feasibility of Metformin for Sepsis Induced AKI
Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury, Metformin
- Trial name
- NCT05900284
- Testing
- Metformin low dose, Metformin high dose
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hernando Gomez
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Bacteremia
Empirical Antibiotic and Outcome in Community-onset Bacteremia
Empirical antibiotic and outcome in Community-onset Bacteremia Caused by third generation cephalosporin resistant Enterobacteriaceae
- Trial name
- NCT03765749
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Interleukin-6
Effectiveness of the Cytokine Hemadsorption on Sepsis
In this prospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.
- Trial name
- NCT05057455
- Testing
- cytokine hemadsorption
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Biruni University
Selective Plasma Filtration
Selective Plasmofiltration for Abdominal Septic Shock: a Clinical Ctudy
Group 1: 34 patients received prolonged hemodiafiltration (CVVHDF) on an emergency basis. Group 2: 35 patients received early isolated CVVHDF.
- Trial name
- SPASS (NCT07121647)
- Testing
- renal replacement therapy., early isolated CVVHDF., combined extracorporeal blood purification therapy
- Where
- Russia
- Volunteers
- 101 people
- Sponsor
- Pirogov Russian National Research Medical University
Bacteremia
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT
Bacteremia is a leading cause of mortality and morbidity in critically ill adults. Although bacteria in the bloodstream (bacteremia) may arise from variable infectious foci (most commonly central vascular catheter related, lung…
- Trial name
- BALANCE (NCT02261506)
- Testing
- 7 days of adequate antibiotic treatment durations, 14 days of adequate antibiotic treatment durations
- Where
- 17 sites in Canada
- Volunteers
- 115 people
- Sponsor
- Sunnybrook Health Sciences Centre
Shock, Septic
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients With Septic Shock
This is a randomised, double-blind, two-stage, placebo controlled study. It is designed to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of 3 doses of nangibotide versus placebo in adult patients…
- Trial name
- NCT03158948
- Testing
- Nangibotide 0.3 mg/kg, Nangibotide 1 mg/kg, Nangibotide 3 mg/kg
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 50 people
- Sponsor
- Inotrem
Bacteremia
Multicenter Blood Culture Quality Improvement
False positive blood culture results due to specimen contamination with bacteria inhabiting patients' skin is a common problem in emergency departments (EDs) in the United States.
- Trial name
- NCT01413555
- Testing
- Blood Culture QI Program
- Where
- 2 sites in United States
- Volunteers
- 14,889 people
- Sponsor
- Vanderbilt University
Bacteremia, Enterobacteriaceae Infections
Ultra Rapid Culture Independent Detection of High-Priority Carbapenem Resistant Enterobacteriaceae Directly From Blood
The purpose of this study is to develop a new and very rapid diagnostic test for identifying a certain type of bacteria called Enterobacteriaceae in blood.
- Trial name
- NCT02482051
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Denver Health and Hospital Authority
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