Clinical trials: Sepsis, completed
Aspergillosis, Candidiasis
An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections
The objective of this study is to evaluate the efficacy, safety and toleration of voriconazole in the primary treatment of systemic or invasive fungal infections due to fungal pathogens for which there is no licensed therapy; and…
- Conditions
- Aspergillosis, Candidiasis, Fungemia, Mycoses
- Trial name
- NCT00001810
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Neonatal Sepsis
Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)
The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.
- Trial name
- NCT00800449
- Where
- Israel
- Volunteers
- 133 people
- Sponsor
- Irina Kessel
Septic Shock, Sepsis
Impact of Systematic Point-of-Care Ultrasound Implementation on Clinical Outcomes and Survival in Septic Shock: A Retrospective Single-Center Cohort Study
This study aims to evaluate the clinical impact of the systematic implementation of point-of-care ultrasound (POCUS) in the management of patients with septic shock in the intensive care unit (ICU).
- Trial name
- SHOCK (NCT07565649)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Sepsis, Corona Virus Infection
The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed.
- Conditions
- Sepsis, Corona Virus Infection, ARDS, Human
- Trial name
- NCT04542538
- Testing
- No intervention, observational study
- Where
- Sweden
- Volunteers
- 9,905 people
- Sponsor
- Uppsala University
Severe Sepsis, Septic Shock
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock.
- Trial name
- NCT00934011
- Testing
- C-reactive protein guided antibiotic therapy, Procalcitonin guided antibiotic therapy
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Federal University of Minas Gerais
Immunocompetent Patient on Septic Shock
Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis)
Septic shock is a frequent pathology responsible for over 30000 deaths/year in France. Its outcome has not been improved despite the knowledge on inflammatory processes; a reason for these lack of results may lay on the lack of…
- Trial name
- BIOSEPSIS (NCT01668329)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Grenoble
Polycystic Ovary Syndrome, Miscarriage
The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether metformin may improve pregnancy rates, and decrease miscarriage rates and complications of pregnancy, such as toxemia and gestational diabetes, in women with polycystic ovary…
- Conditions
- Polycystic Ovary Syndrome, Miscarriage, Infertility, Toxemia
- Trial name
- NCT00994812
- Testing
- metformin
- Where
- 5 sites in Finland
- Volunteers
- 326 people
- Sponsor
- University of Oulu
Shock
Dopamine and Norepinephrine in Shock Patients
The purpose of this study is to compare the efficacy of dopamine and norepinephrine, two commonly used vasopressor agents, in the treatment of shock.
- Trial name
- NCT00314704
- Testing
- dopamine versus norepinephrine
- Where
- 8 sites in Austria, Belgium and 1 more
- Volunteers
- 1,679 people
- Sponsor
- Sepsis Occurrence in Acutely Ill Patients
Sepsis
Comparing Prognostic Performance of SEPSIS 2 and SEPSIS 3 Strategies at the Emergency Service
In 2016, the Third International Consensus proposed a new strategy to screen aggravating risk in patients with septic shock. This strategy is based on quick-SOFA and the SOFA score.
- Trial name
- StraSEP (NCT03355833)
- Volunteers
- 228 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Melioidosis, Systemic Inflammatory Response Syndrome
Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis
Clinical samples [blood and voided urine (only for phase A)] from patient recruited at Sihanouk Hospital Centre of HOPE (SHCH) and HOPE Community Medical Center (CMC) will be processed (decontamination) and shipped to SRI…
- Conditions
- Melioidosis, Systemic Inflammatory Response Syndrome, Suspected or Confirmed Bloodstream Infections
- Trial name
- NCT02668406
- Testing
- Venous blood sampling (2 timepoints) (Phase A and B), Venous blood sampling (1 timepoint) (Phase A and B), Voided urine sampling (first sample) (Phase A)
- Where
- 2 sites in Cambodia
- Volunteers
- 4,203 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Infection, Sepsis
Possible Roles of MDW in Infection Management in Emergency Care
A retrospective study to determine the potential value of MDW among other biomarkers in the diagnosis of infection.
- Trial name
- NCT04448548
- Testing
- blood sample taking
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- Szeged University
Sepsis
Sensitivity and Specificity of Leucocytes Profiling Versus Platelet Indices in Prediction of Clinical Outcome for Candidates With Sepsis. A Bi-centric Observational Clinical Trial
Leucocyte subpopulation and platelet indices analysis can predict clinical outcome
- Trial name
- NCT06612307
- Where
- Egypt
- Volunteers
- 422 people
- Sponsor
- Minia University
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Central Line-associated Bloodstream Infection (CLABSI)
Implementation Program to Improve CHG Bathing Compliance
This study will be a multicenter, cluster randomized, step-wedged design. The unit of randomization will be the inpatient units admitted critically ill patients, with the interventions being carried out over 4 months.
- Trial name
- NCT03898115
- Testing
- CHG Education
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Nephrolithiasis, Urinary Tract Infection (UTI)
Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2
This study will be a multi-institutional randomized clinical trial of a short course of pre-operative antibiotic prophylaxis in addition to perioperative antibiotics prior to undergoing percutaneous nephrolithotomy.
- Conditions
- Nephrolithiasis, Urinary Tract Infection (UTI), Sepsis
- Trial name
- PNLABXPART2 (NCT02829060)
- Testing
- Nitrofurantoin 100 MG, 7d, Gentamicin, 5mg/kg, Ampicillin 2g
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, San Diego
Sepsis, Adult Disease
Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Washington University
The purpose of this study is to demonstrate that addition of the Monocyte Width Distribution (MDW) parameter to current standard of care improves a clinician's ability to recognize sepsis in the Emergency Department, resulting in…
- Conditions
- Sepsis, Adult Disease, Severe Sepsis, Emergency Department
- Trial name
- NCT04353388
- Testing
- CBC-DIFF Monocyte Volume Width Distribution (MDW)
- Where
- United States
- Volunteers
- 1,139 people
- Sponsor
- Beckman Coulter, Inc.
Sepsis
INFLAmmasomes NLRP3 in Platelets and Leukocytes During SEPSIS in Intensive Care Unit
septic shock is the first cause of mortality in intensive care unit. Innate immunity is the body's first line of defense against pathogens
- Trial name
- INFLA-SEPSIS (NCT04635878)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Toulouse
Septic Shock
The Effect of Lactate Clearance Oriented Haemodynamic Therapy on the Outcome of Patients With Septic Shock
The purpose of this study is to explore and assess possible outcome benefits of lactate clearance>30% vs ScvO2 ≥70% in 6 hours as the protocol goal that evaluated adequacy of during early resuscitation of septic shock through a…
- Trial name
- NCT02566460
- Testing
- Resuscitation
- Volunteers
- 360 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis, Immune Dysfunction
Electro-acupuncture at Zusanli, Qihai, and Guanyuan Acupoints Regulate Immune Function in Patients With Sepsis
The purpose of this study was to investigate the biochemical and clinical effects of electro-acupuncture in patients with sepsis.
- Trial name
- EAIm-sepsis (NCT05367986)
- Testing
- electro-acupuncture
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Sepsis, Systemic Inflammatory Response Syndrome (SIRS)
Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients
This study investigated whether giving the probiotic Lactiplantibacillus plantarum DAD-13 to sepsis patients in the intensive care unit (ICU) could help reduce inflammation and improve bowel function.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- LactoSepsis (NCT07072871)
- Testing
- Lactiplantibacillus plantarum DAD-13
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- PT Royal Medikalink Pharmalab
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