Clinical trials: Sepsis - to Reduce Mortality in the Intensive Care Unit
Sepsis - to Reduce Mortality in the Intensive Care Unit
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Sepsis is a severe, life-threatening condition caused by an abnormal host response to infection, which includes systemic inflammation, oxidative stress, and increasing organ dysfunction.
- Trial name
- NCT07655791
- Testing
- Nicotinamide 1000 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Sepsis - to Reduce Mortality in the Intensive Care Unit, Trauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced…
- Trial name
- ROSTIC (NCT06891599)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Sepsis, Septic Shock
Adjunctive Fludrocortisone in Septic Shock
Sepsis is a life-threatening condition caused by the body's dysregulated response to an infection. While corticosteroids are known to help stabilize blood pressure in septic shock, their ability to reduce mortality is still…
- Conditions
- Sepsis, Septic Shock, Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis and Septic Shock
- Trial name
- AFLUDROS-1 (NCT07451886)
- Testing
- Fludrocortisone 100 mcg daily
- Where
- 5 sites in Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Sepsis - to Reduce Mortality in the Intensive Care Unit
Procalcitonin Increase Identifies Critically Ill Patients at High Risk of Mortality
Procalcitonin, a marker of infection has often been compared to clinical pictures as for instance "clinical sepsis". This has given som problems in the interpretation of these studies, because of the lack of good Gold Standards…
- Trial name
- NCT00144638
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Danish Procalcitonin Study Group
Sepsis - to Reduce Mortality in the Intensive Care Unit, Burns Involving 20% or More of Body Surface
Evaluating the Accuracy of Multiple Blood Tests to Diagnose Sepsis in Adult Burn Patients
This prospective diagnostic accuracy study evaluates the performance of presepsin and C-reactive protein (CRP) as early biomarkers for suspected sepsis in adult burn patients.
- Trial name
- BioBurnSepsis (NCT07126574)
- Where
- South Korea
- Volunteers
- 165 people
- Sponsor
- Dohern Kym
Localized Infection, Sepsis
The Procalcitonin and Survival Study
This is a randomised, single blinded, multicentre trial to evaluate whether daily procalcitonin (PCT) measurements and immediate diagnostic and therapeutic responses to abnormal values and day-to-day changes can reduce the…
- Conditions
- Localized Infection, Sepsis, Multiple Organ Failure
- Trial name
- PASS (NCT00271752)
- Testing
- Earlier therapeutic changes regarding infection
- Where
- 9 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Danish Procalcitonin Study Group
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis
Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis
The aim of this study is to investigate if an initial short double dose of beta-lactam antibiotics will reduce mortality in critically ill patients with sepsis.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis, Septic Shock
- Trial name
- BULLSEYE (NCT06766461)
- Testing
- Double dosing of beta-lactam antibiotic
- Where
- Netherlands
- Volunteers
- 980 people
- Sponsor
- Erasmus Medical Center
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker
Phoenixin-14 Downregulation in Sepsis
Background: Sepsis is a leading cause of morbidity and mortality in intensive care units (ICUs) worldwide, accounting for millions of deaths annually.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker, Phoenixin-14 Molecular Downregulation
- Trial name
- NCT07356739
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Firat University
Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration
Comparative Effectiveness of Oxiris Hemofilters Versus Conventional Hemofilters in Septic Patients
We divided patients in 2 groups. First group was the patients who received Oxiris filters during CRRT. Second group was the patiens who have received CRRT filters other than Oxiris.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration, Cytokine
- Trial name
- NCT06735365
- Testing
- CRRT
- Where
- Turkey (Türkiye)
- Volunteers
- 426 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Sepsis - to Reduce Mortality in the Intensive Care Unit, Septic Shock
Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock
Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction and represents a major healthcare problem.
- Trial name
- CARBON (NCT07179276)
- Testing
- CO2gap-guided resuscitation strategy
- Where
- 28 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Clermont-Ferrand