Clinical trials: Sepsis Biomarker
Septic Shock
The Diagnostic and Prognostic Value of Presepsin in Sepsis
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or…
- Trial name
- NCT06180265
- Testing
- presepsin, procalciton, endotoxin
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Foggia
Sepsis, Severe Sepsis
Endothelium in Severe Sepsis
The overall hypotheses of this project is that severe sepsis is associated with endothelial dysfunction; that endothelial dysfunction, in turn, is predictive of subsequent organ failure and death; and that protocolized…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT00793442
- Testing
- Blood Collection and Assays
- Where
- 7 sites in United States
- Volunteers
- 910 people
- Sponsor
- Beth Israel Deaconess Medical Center
Invasive Fungal Infections
Using of Biomarkers and Blood Culture in Early Detection of Systemic Infections
This work aims to: 1. Validate the performance of CRP, and PCT in early differentiating IFI from bacterial bloodstream infections. 2. Compare the results of CRP and PCT with the results of β-D- glucan. 3.
- Trial name
- NCT05737537
- Testing
- procalcitonin ,CRP and 1, 3- β -D- glucan in early diagnosis of invasive infections
- Volunteers
- 90 people
- Sponsor
- Assiut University
Bacteremia
T2 and SeptiCyte RAPID Duration Project
Infection with bacteria and other germs in the blood can be deadly. How long germs stay in the blood is important for two reasons.
- Trial name
- NCT04821661
- Where
- 3 sites in Australia
- Volunteers
- 102 people
- Sponsor
- The University of Queensland
Intraabdominal Infections
Prognostic Value of Proadrenomedullin in Intra-abdominal Sepsis
An observational, prospective study whose main objective is to measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.
- Trial name
- NCT03061500
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Sepsis
Diagnostic Performance of a New Bio-marker During Bacterial Sepsis
Sepsis is a constant concern in ICU, frequent and severe, it requires early diagnosis and prompt implementation of the etiological treatment.
- Trial name
- BACTIDIAG (NCT02721134)
- Testing
- additional blood tubes
- Where
- 6 sites in France, Monaco
- Volunteers
- 450 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation
Due to the failure of the respiratory system, many patients admitted to the Intensive Care Units (ICUs) require the institution of invasive mechanical ventilation (MV), aiming at maintaining gas exchange, reversing respiratory…
- Trial name
- NCT03464071
- Testing
- Hyperinflation with mechanical ventilator, Manual hyperinflation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Septic Shock, Left Ventricular Systolic Dysfunction
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
Septic shock is a major cause of death in intensive care. Septic shock is often dominated by profound changes in organ functions, of which cardiac failure is one of the most severe.
- Conditions
- Septic Shock, Left Ventricular Systolic Dysfunction, Left Ventricular Diastolic Dysfunction
- Trial name
- Septic Heart (NCT01747187)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- University Hospital, Linkoeping
Septic Shock, Immunocompromised Patients
BioMArkeRs of INflammation, Infection, and Immunity in the Critical Area (MARINA): the Use of Inflammatory and Immunity Biomarkers as Early Predictors of Clinical Severity, Organ Damage, Response to Treatment, and Infectious Complications in Patients Admitted to the Critical Care Area.
The MARINA study (bioMARkers of INflammation, infection, and immunity in critical cAre) is a multicenter, prospective and retrospective observational cohort study designed to evaluate the diagnostic and prognostic role of…
- Trial name
- MARINA (NCT07682766)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Sepsis
Sepsis Multiomic Analysis & Risk sTratification in China
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and delayed diagnosis remains a major driver of mortality, while traditional biomarkers (PCT, CRP, lactate) have limited early…
- Trial name
- China SMART-1 (NCT07599644)
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Yuebei People's Hospital
Sepsis, Cardiac Arrest
Validation of Molecular and Protein Biomarkers in Sepsis
Background: Sepsis (blood poisoning) is a clinical syndrome characterised by a dysregulated host response to infection causing life-threatening organ dysfunction which results in admission to an intensive care unit.
- Conditions
- Sepsis, Cardiac Arrest, Pneumonia, Abdominal Sepsis
- Trial name
- VAMp-sepsis (NCT04289506)
- Testing
- mRNA expression
- Where
- 3 sites in United Kingdom
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Public Health England
Sepsis
Identification and Clinical Efficacy Analysis of Biomarkers in Sepsis Patients
Sepsis, a severe response to bacterial infection, lacks understanding of immunometabolic features that can identify high-risk patients.
- Trial name
- NCT05911711
- Testing
- Prognostic factor
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Kangdong Sacred Heart Hospital
Sepsis at Intensive Care Unit
Validation of a Urinary Biomarker as Diagnostic Tool for AKI in Sepsis
BACKGROUND: Early diagnosis and prognostication of acute kidney injury in patients with sepsis is key to further our understanding this disease and in the evaluation of new interventions for this condition.
- Trial name
- NCT01981993
- Testing
- Urinary proteomic analysis
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Sepsis, Infection
Plasma Neprilysin for Predicting Sepsis Within 48 Hours in ICU Patients With Infection or Suspected Infection
The goal of this multicenter prospective observational cohort study is to determine whether plasma neprilysin can predict the development of sepsis within 48 hours in adults admitted to an intensive care unit with confirmed or…
- Trial name
- NEPSIS (NCT07796386)
- Testing
- Plasma Neprilysin Measurement, Conventional Sepsis Biomarker Measurement, Sublingual Microcirculation Assessment
- Where
- 2 sites in China
- Volunteers
- 488 people
- Sponsor
- Zhujiang Hospital
Antibiotic Side Effect
Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU
Using Procalcitonin Tests to reduce antibiotics duration in Neurosurgical patients with Ventilated Associated Pneumonia
- Trial name
- NCT06395454
- Testing
- Shorten antibiotics duration based on procalcitonin test levels
- Volunteers
- 48 people
- Sponsor
- Universiti Sains Malaysia
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker
Phoenixin-14 Downregulation in Sepsis
Background: Sepsis is a leading cause of morbidity and mortality in intensive care units (ICUs) worldwide, accounting for millions of deaths annually.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker, Phoenixin-14 Molecular Downregulation
- Trial name
- NCT07356739
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Firat University
Normal Control, SIRS
Sepsis Metabolomics
The occurrence of sepsis and its relevant multiple organ dysfunction remain a major problem in intensive care units with high morbidity and mortality.
- Conditions
- Normal Control, SIRS, Sepsis, Severe Sepsis
- Trial name
- NCT01649440
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Sepsis
Dynamic Infection Kinetics for Early Diagnosis, Monitoring, and Prognostication of Sepsis in Adult Oncology Patients: Evaluating Serial Infection Biomarkers, Blood Culture Kinetics, Treatment Response, Disease Severity, and Clinical Outcomes
Dynamic Infection Kinetics as an Early Diagnostic and Monitoring Tool for Sepsis in Oncology Patients This study aims to evaluate whether changes over time in infection-related biomarkers and blood culture findings can help…
- Trial name
- NCT07795502
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Sepsis
Procalcitonin Monitoring May Decrease Antibiotic Use in the Intensive Care Unit
Sepsis is common and is associated with significant mortality, morbidity and health-care costs. Unfortunately, its diagnosis is not straightforward because its signs and symptoms are neither specific nor sensitive; in addition…
- Trial name
- NCT01085994
- Testing
- Literature search
- Where
- Greece
- Sponsor
- University of Athens
Hypertensive Disorder of Pregnancy, Gestational Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation…
- Conditions
- Hypertensive Disorder of Pregnancy, Gestational Hypertension, Preeclampsia
- Trial name
- HYPER-endoEV-p (NCT07728656)
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek