Clinical trials: Sepsis Syndromes
Sepsis, Septic Shock
Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit
Infections due to extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a major public health concern, in particular in the intensive care unit (ICU), due to the increase in their incidence.
- Trial name
- PITAGORE (NCT05565222)
- Testing
- Piperacillin/tazobactam or temocillin, Meropenem
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Effect of Taurolidin on Prevention of Bloodstream Infection
Home parenteral nutrition (HPN) is a validated technique for patients with various intestinal disease leading to chronic malabsorption or obstruction, whatever the aetiology.
- Trial name
- Nutrilock (NCT00545831)
- Testing
- Taurolidine, Physiologic Serum
- Where
- 7 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Rouen
Sepsis
Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship
The purpose of this study is to evaluate if implementation of the Sepsis Transition and Recovery (STAR) program within a large healthcare system will improve outcomes for high-risk patients with suspected sepsis, while…
- Trial name
- ENCOMPASS (NCT04495946)
- Testing
- Sepsis Transition and Recovery (STAR) program, Usual care
- Where
- United States
- Volunteers
- 3,894 people
- Sponsor
- Wake Forest University Health Sciences
Sepsis, Infections
Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)
A challenge to intermittent vancomycin dosing in young infants is the avoidable delay caused by the need to wait until steady state (i.e.
- Conditions
- Sepsis, Infections, Bacteremia
- Trial name
- VANCAPP (NCT05770622)
- Testing
- First-dose trough dose adjustment calculator - using early TDM (first-dose trough) to determine an early dose adjustment if the predicted steady-state trough is outside of target range (10-20mg/L)
- Where
- 4 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Murdoch Childrens Research Institute
Abdominal Sepsis, Abdominal Infection
Closed or Open Abdomen for the Management of Abdominal Sepsis
This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED); or B) leave the fascia open after…
- Trial name
- NCT03163095
- Testing
- Open Abdomen Management with ANPPT dressing, Closed Abdomen Management
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- University of Calgary
Mycobacterium Avium-intracellulare Infection, HIV Infections
Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in HIV Positive Patients With CD4 Counts = or < 200: Treatment IND Study
Primary: To provide rifabutin to HIV positive patients in an attempt to prevent or delay Mycobacterium avium Complex (MAC) infection by a daily dose of rifabutin.
- Trial name
- NCT00002080
- Testing
- Rifabutin
- Where
- United States
- Sponsor
- Pharmacia
Gram-Positive Bacterial Infections, Vancomycin
Clinical Decision Support Tool for Vancomycin Dosing in Children
This study will evaluate the pharmacokinetic and pharmacodynamic dosing properties of intravenous vancomycin in pediatric patients using a novel computer decision support (CDS) tool called Lyv.
- Conditions
- Gram-Positive Bacterial Infections, Vancomycin, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT04911270
- Testing
- Computer Decision Support Tool Intervention Group, Matched Historical Controls
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Maryland, Baltimore
Microcirculation
Establishing Normal Ranges of Microcirculatory Function as Determined by CytoCam-IDF Imaging
When infection strikes, the body's immune system reacts by producing chemicals in the bloodstream and changes in white blood cells to attack the infecting organism (bacteria, viruses or other organisms) and prevent it spreading.
- Trial name
- NCT03044483
- Testing
- Measurement of sublingual microcirculatory parameters
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
SEPTIC SHOCK, SEPSIS SYNDROME
Early Physical Therapy in Patients With Sepsis
It is clearly shown that patients in the Intensive care Unit (ICU) with severe sepsis or multi organic failure are very susceptible to develop neuromuscular complications.
- Conditions
- SEPTIC SHOCK, SEPSIS SYNDROME, Multiple Organ Dysfunction Syndrome
- Trial name
- EARTH-ICU (NCT01787045)
- Testing
- Early and Active Physical Therapy, Passive Range of Motion
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sepsis, Septic Shock
PRIME Sepsis Trial: Early Sepsis Detection in the Emergency Department Using Presepsin and Immature Granulocytes
Early identification and timely intervention for sepsis in the emergency department (ED) are critical for improving patient outcomes.
- Trial name
- NCT07822412
- Where
- Taiwan
- Volunteers
- 699 people
- Sponsor
- Chang Gung Memorial Hospital
Septic Shock
Lipopolysaccharide Adsorption At Septic Shock
Sepsis is a global healthcare burden sepsis, it reaches 20-30 million cases annually (WHO data). Numerous studies have shown that extracorporeal hemoperfusion therapies that eliminate endotoxin and\or excess of cytokines improve…
- Trial name
- LASSO (NCT04827407)
- Testing
- Efferon LPS hemoperfusion
- Where
- 4 sites in Russia
- Volunteers
- 58 people
- Sponsor
- Efferon JSC
Severe Sepsis, Septic Shock
Scandinavian Starch for Severe Sepsis/Septic Shock Trial
By tradition hydroxyethyl starch (HES) is used to obtain fast circulatory stabilisation in critically ill. High molecular weight HES may, however, cause acute kidney failure in patients with severe sepsis.
- Trial name
- 6S (NCT00962156)
- Testing
- 6% Hydroxyethyl starch 130/0.4, Ringers acetate
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 804 people
- Sponsor
- Anders Perner
Clinically Significant Bacteremia, Organ Transplantation
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carbapenemase-producing Enterobacterales in Solid Organ Transplantation: an Observational Multinational Study.
Main objective: to observationally assess the efficacy and safety of different antimicrobials in BSI due to ESBL or carbapenemase-producing Enterobacterales in SOT. Secondary objectives: 1.
- Conditions
- Clinically Significant Bacteremia, Organ Transplantation, Infection, Bacteremia
- Trial name
- INCREMENT-SOT (NCT02852902)
- Where
- 3 sites in Spain
- Volunteers
- 820 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Sepsis, Emergency Medical Services
Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures
The goal of this quality improvement study is to measure the impact of incorporation of a manual rapid fluid infuser (RFI) for intravenous crystalloid infusion in patients with suspected sepsis in the prehospital interval.
- Conditions
- Sepsis, Emergency Medical Services, Quality Improvement, Shock, Septic
- Trial name
- NCT05961137
- Testing
- Incorporation of Rapid Fluid Infusion Device in Prehospital Suspected Sepsis Protocol, Conventional Prehospital Suspected Sepsis Protocol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Orange Park Medical Center
Sepsis, Septic Shock
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments
In this clinical trial the effect of early administration of Vitamin C is investigated in patients admitted at the emergency department with sepsis or septic shock.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- c-easie (NCT04747795)
- Testing
- Vitamin C, Normal saline
- Where
- 8 sites in Belgium
- Volunteers
- 301 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sepsis, Hyperglycemia
Clinical Validation of Continuous Glucose Monitoring in Glycemic Management of Critically Ill Sepsis Patients
Poor glycemic control is common in critically ill patients with sepsis and is associated with increased morbidity and mortality; however, achieving safe and effective glucose management in the ICU remains challenging with…
- Conditions
- Sepsis, Hyperglycemia, Glycemic Control
- Trial name
- NCT07686939
- Testing
- Continuous Glucose Monitoring (CGM) with FreeStyle Libre II System
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Sepsis, Septic Shock
Function of Circulating Exosomes in Sepsis-induced Immunosuppression
This is a single-center prospective bio-specimen analysis and observational study aiming to define immune pathways disrupted in bacterial sepsis and to identify clinically useful biomarkers of immune status.
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome, Sepsis Bacterial
- Trial name
- NCT04979767
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Kansas Medical Center
Systemic Inflammatory Response Syndrome
Serum Level of Lipopolysaccharide-binding Protein (LBP) and Atherosclerosis in Hemodialysis Patients
Background In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation.
- Trial name
- NCT03427307
- Where
- Taiwan
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey
In this observational study, it is aimed to investigate the mortality and morbidity rates of hospital-acquired blood stream infections that are treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition
- Trial name
- NCT04304456
- Testing
- Treatment
- Volunteers
- 810 people
- Sponsor
- SCARE (Study group for carbapenem resistance)
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