Clinical trials: Septic
Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration
Comparative Effectiveness of Oxiris Hemofilters Versus Conventional Hemofilters in Septic Patients
We divided patients in 2 groups. First group was the patients who received Oxiris filters during CRRT. Second group was the patiens who have received CRRT filters other than Oxiris.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration, Cytokine
- Trial name
- NCT06735365
- Testing
- CRRT
- Where
- Turkey (Türkiye)
- Volunteers
- 426 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Sepsis, Sepsis and Septic Shock
Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients
The condition of sepsis patients changes rapidly, whom are often accompanied by impaired respiratory, circulatory, renal, and coagulation functions. So far, the prognosis of sepsis at home and abroad is not ideal.
- Conditions
- Sepsis, Sepsis and Septic Shock, Infection
- Trial name
- sepsis model (NCT06904001)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sepsis, Severe Sepsis
Inferior Vena Cava Collapsibility Index in Severe Sepsis
There is debate regarding the use of non invasive (ultrasound assessed) parameters of fluid volume status in patients with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02195830
- Testing
- Ultrasound of the inferior vena cava
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- Teesside University
Sepsis
Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient
Resuscitation failure, oxidative stress and necroptosis were able to predict mortality in septic patient
- Trial name
- NCT04169412
- Testing
- Blood Collection
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Sriwijaya
Sepsis, Septic Shock
Multicenter Symphony™ IL-6 Monitoring Sepsis ED Pilot Study
The primary objective of this study is to establish an IL-6 concentration cutoff that predicts sepsis or septic shock (according to the Third International Consensus Definitions (Sepsis-3 criteria)) in patients who are admitted…
- Trial name
- SYMON III (NCT07425587)
- Where
- 5 sites in United States
- Volunteers
- 450 people
- Sponsor
- Bluejay Diagnostics, Inc.
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Shock, Septic
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
This is a randomized, double-blind, placebo-controlled dose-selection study in which two doses of nangibotide are tested versus placebo.
- Trial name
- ASTONISH (NCT04055909)
- Testing
- nangibotide low dose, nangibotide high dose
- Where
- 43 sites in Belgium, Denmark and 4 more
- Volunteers
- 355 people
- Sponsor
- Inotrem
Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit
Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock
The purpose of this study is to determine whether an aggressive strategy of severe sepsis patients since pre hospital care, including early antibiotics administration, hemodynamic optimization, and opotherapy when indicated…
- Trial name
- SSS (NCT02473263)
- Testing
- Ceftriaxone, Piperacillin tazobactam, Norepinephrine
- Where
- France
- Volunteers
- 398 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Carotid Ultrasounds Measurements in Septic Shock
The aim of the study is to assess carotid ultrasounds measurements, namely corrected flow time (FTc), velocity time integral (VTI) and respirophasic variation in carotid artery blood flow peak velocity (ΔVpeak), as a predictor of…
- Trial name
- NCT05444621
- Testing
- Ultrasound and doppler
- Volunteers
- 72 people
- Sponsor
- Assiut University
Peritonitis, Sepsis
Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis
The aim of this prospective, randomized, controlled trial is to provide evidence for adjuvant IgGAM treatment with regard to 1. Improvement of patient outcomes for peritonitis.
- Conditions
- Peritonitis, Sepsis, Septic Shock
- Trial name
- PEPPER (NCT03334006)
- Testing
- Pentaglobin®/Standard of Care
- Where
- 20 sites in Austria, Germany
- Volunteers
- 200 people
- Sponsor
- RWTH Aachen University
Sepsis, Septic Shock
Multicenter Symphony IL-6 Monitoring Sepsis ICU Study
The primary objective of this study is to establish an IL-6 concentration cutoff and optimal time point(s) for using Symphony IL-6 that predict 28-day mortality in patients who are admitted or are intended to be admitted to the…
- Trial name
- SYMON (NCT06181604)
- Where
- 7 sites in United States
- Volunteers
- 143 people
- Sponsor
- Bluejay Diagnostics, Inc.
Sepsis
Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock
The purpose of this research study is to determine if a chemical marker in the blood, hypoxia-inducible factor (HIF-1 alpha), can be used to predict subject's hospital outcomes when the subject is diagnosed with sepsis.
- Trial name
- NCT02163473
- Testing
- Septic patients, Healthy Control
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Florida
Osteoarticular Infections
Molecular Microbiology in Osteo-arthritis Infection
Osteoarticular infections are painful and disabling diseases that require antimicrobial treatment adapted to the microorganisms implicated.
- Trial name
- MOLOS (NCT01193803)
- Testing
- Microbiological cultures and Molecular biology
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
Non Invasive Evaluation of Fluid Responsiveness in Septic Patient
The study aims to evaluate the accuracy of fluid responsiveness assessment with non-invasive cardiometry compared to ultrasound guided inferior vena cava (IVC) collapsibility for management of critically ill septic patients with…
- Trial name
- NCT05310942
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Sepsis, Septic Shock
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments
In this clinical trial the effect of early administration of Vitamin C is investigated in patients admitted at the emergency department with sepsis or septic shock.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- c-easie (NCT04747795)
- Testing
- Vitamin C, Normal saline
- Where
- 8 sites in Belgium
- Volunteers
- 301 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Shock, Septic
Vitamin C, Hydrocortisone and Thiamine for Septic Shock
Prior data has shown that both corticosteroids and vitamin C reduce the activation of nuclear factor ƘB (NFƘB), thereby ultimately attenuating the systemic inflammatory response to sepsis/septic shock and augmenting the…
- Trial name
- CORVICTES (NCT03592693)
- Testing
- Combined Vitamin C and Stress-Dose Hydrocortisone
- Where
- 2 sites in Greece
- Volunteers
- 24 people
- Sponsor
- University of Athens
Disseminated Intravascular Coagulation (DIC), Reanimation
EARLY DIAGNOSIS OF SEPTIC DIC
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice.
- Conditions
- Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
- Trial name
- EASY-DIC (NCT07630415)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Severe
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis
To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
- Trial name
- BIS6 (NCT03244293)
- Testing
- no intervention
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Morality, Sepsis
Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock
The aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.
- Conditions
- Morality, Sepsis, Septic Shock
- Trial name
- NCT05921825
- Testing
- Red cell distribution width, lactate albumin ratio measurement
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Shock; Septic, Critical Illness
Targeted Tissue Perfusion Versus Macrocirculatory-guided Standard Care in Patients With Septic Shock
Background: The recommended monitoring and target levels in septic shock (SSC Guidelines 2012) including mean arterial pressure (MAP) target are not based on robust clinical data.
- Trial name
- TARTARE-2S (NCT02579525)
- Testing
- Hemodynamical treatment TTP, Hemodynamical treatment MCG
- Where
- 2 sites in Finland, Switzerland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
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