Clinical trials: Septic
Septic Shock
Effects of Levosimendan on Microcirculation in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to: investigate the effects of a combination of levosimendan and inhaled nitric oxide on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00800306
- Testing
- Levosimendan, dobutamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
Early Albumin Resuscitation During Septic Shock
Objective: To determine whether the early administration of albumin as an expander and antioxidant would improve survival on the 28th day for septic shock patients.
- Trial name
- NCT00327704
- Testing
- albumin, saline
- Where
- France
- Volunteers
- 794 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Sepsis, Septic Shock
Clinical Efficacy of Megadose Vitamin C in Sepsis
In this multicenter, randomized, single-blind, placebo-controlled clinical trial. Patients will be randomly assigned to receive Vitamin C or placebo for 4 days or until ICU discharge (whatever come first).
- Trial name
- CEMVIS (NCT05194189)
- Testing
- Vitamin C, 5% glucose injection
- Where
- 4 sites in China
- Volunteers
- 234 people
- Sponsor
- Zhujiang Hospital
Sepsis, Severe Sepsis With Septic Shock
Wearable Sweat Sensor for High-Concentration Lactate Monitoring in Critically Ill Patients
Blood lactate level is closely associated with the prognosis of patients with sepsis and septic shock. Clinical guidelines explicitly recommend blood lactate monitoring in septic patients and lactate-guided fluid resuscitation…
- Conditions
- Sepsis, Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
- Trial name
- NCT07716371
- Testing
- High-Concentration Sweat Lactate Wearable Monitoring Device, Commercial Sweat Collection Device (HELA)
- Volunteers
- 86 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Severe Sepsis
Investigation of Correlation Between Interstitial and Arterial Blood Glucose Concentrations in Septic Patients
This is a mono-centre trial performed at the medical ICU at the Medical University Graz. There will be a study visit (V1) and a follow-up assessment (V2).
- Trial name
- NCT00463645
- Testing
- microdialysis, microperfusion
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Critical Illness, Hemodynamic Instability
Complications Related to Transpulmonary Thermodilution
The transpulmonary thermodilution is commonly used in patients with acute circulatory failure in the intensive care unit and for monitoring surgical patients at high risk.
- Conditions
- Critical Illness, Hemodynamic Instability, Septic Shock, Acute Respiratory Distress Syndrome
- Trial name
- COTRADIL (NCT04319965)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Bicetre Hospital
Sepsis
Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown.
- Trial name
- NCT00410111
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis
Correlation Between PTP1B Expression and Organ Failure During Sepsis
Despite major advances in the treatment and understanding of the pathophysiological mechanisms, mortality of severe sepsis remains high, ranging from 25 to 50%.
- Trial name
- SEPP1B (NCT02295514)
- Testing
- PTP1B dosage
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Rouen
Septic Shock
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS…
- Trial name
- NCT00604019
- Testing
- Dopamine, Norepinephrine
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Wound Infection
Continuous Topical Instillation for Open Abdomen in the Septic Patients With Complicated Intra-abdominal Infections
The closed systems, such as conventional negative pressure wound therapy (NPWT), were usually avoided in infected or critical colonized wounds.
- Trial name
- Triple-tube (NCT02029339)
- Testing
- Continuous topical triple-tube irrigation and suction, SOC
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Southeast University, China
Meningococcal Infections, Septic Shock
Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis
Use of brain natriuretic peptide to evaluate the cardiac function in the course of meningococcal septic shock or severe sepsis.
- Conditions
- Meningococcal Infections, Septic Shock, Severe Sepsis
- Trial name
- SAMIRA (NCT02041663)
- Testing
- BNP
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Staphylococcal Infections, Osteomyelitis
Ceftriaxone as Home IV for Staph Infections
Patients who are admitted to hospital with serious infections, such as those in bone, joints or spine, require a long course of intravenous (IV) antibiotics.
- Conditions
- Staphylococcal Infections, Osteomyelitis, CNS Infection, Septic Arthritis
- Trial name
- NCT04141787
- Testing
- Ceftriaxone, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
- Where
- 2 sites in Canada
- Volunteers
- 310 people
- Sponsor
- Vancouver Island Health Authority
Sepsis
Derivation and Validation of a Prognostic Model for Septic Patients at Hospital Admission
The aim of the present study is to develop a prognostic tool to assess the risk of dead and major complications in patient admitted to hospital for infection.
- Trial name
- NCT03601767
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Ospedaliera San Paolo
Septic Shock
Methylene Blue as a Third-line Vasopressor in Septic Shock
A randomized, prospective study comparing ProvayBlue® to standard care with multiple sympathomimetic vasopressors.
- Trial name
- NCT04089072
- Testing
- Methylene Blue, Phenylephrine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Carilion Clinic
Joint Effusion, Septic Arthritis
Development and Validation of a Simple Diagnostic Tool Predictive of the Aseptic Character of Joint Effusion
Development and validation of a simple diagnostic tool predictive of the aseptic character of joint effusion in the primary care setting.
- Conditions
- Joint Effusion, Septic Arthritis, Arthritis
- Trial name
- PRASEPT (NCT03979937)
- Testing
- Arthrocentesis
- Where
- France
- Volunteers
- 328 people
- Sponsor
- Centre Hospitalier le Mans
Joint Effusion
Use of Infrared Spectroscopy in Septic Arthritis Diagnosis
The main objective of this study is to assess the ability of Fiber-optic Evanescent Wave Spectroscopy (FEWS) to discriminate synovial fluids samples of septic arthritis patients from other causes of joint effusion by analyzing ex…
- Trial name
- SynoFAST (NCT02860871)
- Testing
- infrared spectroscopy
- Where
- France
- Volunteers
- 611 people
- Sponsor
- Rennes University Hospital
Sepsis, Septic Shock
Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01)
Sepsis remains the leading cause of ICU admission in neutropenic patients. This condition remains associated with a high morbidity and mortality, with hospital mortality of 60% when vasopressors are required.
- Conditions
- Sepsis, Septic Shock, Hematologic Malignancy, Tumor
- Trial name
- NCT05443854
- Testing
- Aminoglycosides intervention, Lack of protective isolation intervention, No systematic aminoglycosides intervention - standard arm
- Volunteers
- 340 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Infection, Osteomyelitis
Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections
Because of its prolonged terminal half-life, dalbavancin is an extremely attractive option in treating Gram-positive infections caused by S. aureus including MRSA, and streptococcal species.
- Conditions
- Bone Infection, Osteomyelitis, Septic Arthritis, Joint Infection
- Trial name
- NCT03426761
- Testing
- Dalbavancin, Vancomycin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Infectious Diseases Physicians, Inc.
Head Trauma, Polytrauma
Comparative Study for the Validity of Various Severity Scoring System
Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality
- Conditions
- Head Trauma, Polytrauma, Pre-Eclampsia, Sepsis
- Trial name
- NCT04683094
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether…
- Trial name
- PRoMPT BOLUS (NCT04102371)
- Testing
- Lactated Ringer, Normal Saline, Plasma-lyte
- Where
- 22 sites in United States
- Volunteers
- 9,041 people
- Sponsor
- Children's Hospital of Philadelphia
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