Clinical trials: Septic
Sepsis, Septic Shock
Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients
This prospective, randomized, controlled trial aimed to evaluate whether fluid resuscitation guided by the Peripheral Perfusion Index (PPI) could reduce the incidence of Acute Skin Failure (ASF) in elderly critically ill…
- Conditions
- Sepsis, Septic Shock, Acute Skin Failure
- Trial name
- PPI-PROTECT (NCT07367113)
- Testing
- Peripheral Perfusion Index-guided Fluid Resuscitation Protocol, Conventional Goal-Directed Fluid Resuscitation
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ying Wang
Intubated ICU Patients, Sepsis and Septic Shock
Association of Arterio-Venous Oxygen and Carbon Dioxide Gradients With Tissue Hypoperfusion and Mortality in Sepsis
In patients with sepsis who are treated in the intensive care unit under invasive mechanical ventilation, the combined evaluation of ScvO₂ and PcvCO₂ may provide a comprehensive insight into tissue oxygenation and metabolic…
- Trial name
- NCT07711405
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Septic Shock
Evaluation of New Hemodynamic Indices
The objective is to determine the sensitivity and specificity via Receiver Operating Characteristic (ROC) curve of Global Longitudinal Strain (GLS) The secondary objectives are the same for the change in the amount of carbon…
- Trial name
- EVOLVE (NCT03961594)
- Testing
- expansion volémique
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Septic Shock
Hemodynamic Effects of Dexmedetomidine in Septic Shock
The current treatment regimen of patients with septic shock requires a sufficient hemodynamic support aiming to preserve tissue oxygen requirements and perfusion.
- Trial name
- NCT02638545
- Testing
- Dexmedetomidine
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Roma La Sapienza
Septic Shock
Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock
The purpose of this study is to evaluate the efficacy and safety of the combination therapy of hydrocortisone and fludrocortisone among adult patients with septic shock.
- Trial name
- NCT07383103
- Testing
- Hydrocortisone plus Fludrocortisone, Standard care
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Northern Jiangsu People's Hospital
Septic Shock
Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients
We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.
- Trial name
- ClMLsepsis (NCT03700346)
- Testing
- microdialysis
- Where
- 2 sites in Tunisia
- Volunteers
- 73 people
- Sponsor
- Military Hospital of Tunis
Sodium Balance
Comparing Sodium to Fluid Balance in Predicting Respiratory Dysfunction in Critically Ill Septic Patients
Critically ill septic patients are at risk of positive sodium balance due to inadvertent excess administration, which may be over twice the daily requirement of sodium for healthy individuals This research will estimate sodium…
- Trial name
- NCT06771869
- Testing
- Sodium balance
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Acute Respiratory Distress Syndrome, Septic Shock
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
The implementation of this project will improve the effectiveness of surgical treatment and reduce the level of complications and mortality among patients with heart failure and heart failure in the terminal stage.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Sepsis
- Trial name
- OST (NCT05042622)
- Testing
- Cytokine adsorber filter, Extracorporeal hemoperfusion cartridge
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Septic Shock
Therapeutic Plasma Exchange in Septic Shock: A Pilot Study
The investigators propose to conduct a multi-center randomized pilot feasibility trial comparing therapeutic plasma exchange to standard of care in patients diagnosed with septic shock.
- Trial name
- PLEXSIS (NCT05093075)
- Testing
- Therapeutic Plasma Exchange
- Where
- 11 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Thrombocytopenia, Septic Shock
Mortality Due to Septic Shock Associated With Thrombocytopenia
A prospective longitudinal study similar to the one performed by Claushuis and colleagues (2016) will be performed in order to further understand the epidemiology and clinical relationship between platelet levels and mortality…
- Conditions
- Thrombocytopenia, Septic Shock, Sepsis Bacterial
- Trial name
- NCT03617965
- Testing
- Platelet count
- Where
- Mexico
- Volunteers
- 350 people
- Sponsor
- Universidad de Guanajuato
Adult Patients With Septic Shock Admitted in Intensive Care Unit
Remote Ischemic Postconditioning in Septic Shock
Septic shock is a leading cause of death worldwide despite intensive research efforts. Only a few interventions have been proven to be effective in improving patient-centered outcomes.
- Trial name
- RIPOST-sepsis (NCT07273942)
- Testing
- Remote ischemic conditioning, No intervention
- Where
- 23 sites in France
- Volunteers
- 720 people
- Sponsor
- Hospices Civils de Lyon
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Sepsis, Septic Shock
Cardiovascular Phenotypes in Sepsis
This prospective observational study will investigate cardiovascular phenotypes in adults with sepsis and hemodynamic instability.
- Conditions
- Sepsis, Septic Shock, Cardiovascular Dysfunction, Microcirculatory Dysfunction
- Trial name
- CaPS (NCT07442032)
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Mechanical Ventilation, Mortality
Septic Shock em Steroids
Septic shock is a frequent reason for admission on pediatric intensive care units. Interventions which can change morbidity and mortality of septic shock patients are of great interest.
- Trial name
- NCT01047670
- Testing
- Hydrocortisone
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Unidade de Terapia Intensiva
Sepsis, Severe Sepsis
Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya
Sepsis is a clinical syndrome representing deranged hemodynamics (such as tachycardia) secondary to severe infection. In high-income countries (HICs), early resuscitation of septic patients with protocol-driven therapy, including…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02346331
- Testing
- WHO algorithm of fluid boluses guided by physical examination, Frequent patient monitoring, Early administration of empiric antibiotics
- Where
- Kenya
- Volunteers
- 198 people
- Sponsor
- Duke University
Shock, Septic
Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test
A randomized controlled clinical trial to evaluate whether a passive leg raising test to guide fluid therapy of patients with septic shock can reduce fluid balance and weight gain.
- Trial name
- OFTaPLR (NCT02301585)
- Testing
- Passive Leg Raising Test, Standard of care
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska Institutet
TKA Infection
Knee Hinge Prosthesis Following TKA Infection
Between 2009 and January 2016, the investigators included 49 patients from four hospitals in Lyon who had a Total Knee Arthroplasty (TKA) infection and who benefited of a knee arthroplasty revision with a rotating hinge…
- Trial name
- NCT02856971
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock, Acute Kidney Injury
MCO Membrane Efficiency in Septic Shock Patients
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled…
- Trial name
- NCT04834921
- Testing
- Ultraflux® EMiC®2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fiorenza Ferrari
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic
Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients
In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality.
- Conditions
- Sepsis, Septic, Bacteremia and Sepsis, Intensive Care Medicine
- Trial name
- NCT06958354
- Where
- Turkey (Türkiye)
- Volunteers
- 1,529 people
- Sponsor
- Gulhane Training and Research Hospital
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