Clinical trials: Septic
Septic Shock
Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT
To assess the efficiency and safety of combined extracorporeal blood purification in patients with septic shock in Neurosurgical ICU in comparison with the efficiency and safety of the continuous renal replacement therapy (CRRT).
- Trial name
- NEUROCOMB (NCT04152174)
- Testing
- Combined extracorporeal blood purification, CRRT
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Burdenko Neurosurgery Institute
Cirrhotics With Septic Shock and Acute Kidney Injury
Early Versus Late Sustained Low Efficiency Dialysis in Critically Ill Cirrhotics With Septic Shock and Acute Kidney Injury
Consecutive patients with cirrhosis and septic shock with AKI who give written informed consent will be included in this prospective trial. At baseline NT-Pro BNP, urine N-GAL will be done for all patients.
- Trial name
- NCT02937961
- Testing
- Early SLED, Late SLED
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Septic Shock
Comparison Between Using Cardiometry and IVC Collapsibility
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Septic shock, a severe form of sepsis, is characterized by persistent hypotension and cellular/metabolic…
- Trial name
- NCT07411469
- Testing
- Cardiometry
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Sodium Balance
Comparing Sodium to Fluid Balance in Predicting Respiratory Dysfunction in Critically Ill Septic Patients
Critically ill septic patients are at risk of positive sodium balance due to inadvertent excess administration, which may be over twice the daily requirement of sodium for healthy individuals This research will estimate sodium…
- Trial name
- NCT06771869
- Testing
- Sodium balance
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Septic Shock, Multiorgan Failure
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
- Conditions
- Septic Shock, Multiorgan Failure, Sepsis
- Trial name
- NCT07539883
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Seoul National University Bundang Hospital
Septic Shock, Severe Sepsis
Early Use of Norepinephrine in Septic Shock Resuscitation
Current septic shock guideline recommends fluid resuscitation as the first treatment. Vasopressors, including norepinephrine is recommended to start after achieve adequate fluid therapy.
- Trial name
- CENSER (NCT01945983)
- Testing
- Early norepinephrine
- Where
- Thailand
- Volunteers
- 310 people
- Sponsor
- Mahidol University
Sepsis and Septic Shock
MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK
Sepsis-induced immunosuppression (SIS) is a common complication in patients with septic shock. Reduced expression of Human leukocyte antigen isotype DR (HLA-DR) on circulating monocytes is a marker for SIS and correlates with…
- Trial name
- MIRSEP (NCT07597122)
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Kidney Injury Due to Sepsis
N/LP Ratio as Predictor of Mortality in Septic AKI Patients
To evaluate the role of Neutrophils to lymphocytes and platelets ratio (N/LP ratio) as a biomarkers for mortality in septic -AKI
- Trial name
- NCT05559086
- Volunteers
- 200 people
- Sponsor
- Mahmoud Kamel Mohamed Abd elhaq
Septic Shock, Critical Illness
Myocardial Work in Septic Shock Patients
Myocardial strain analysis has emerged in the last decade as a reliable tool for studying myocardial mechanics, adding information on cardiac performance when compared with traditional parameters of left ventricle (LV) systolic…
- Trial name
- MYWORKSS (NCT05159154)
- Testing
- Myocardial Work
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Humanitas Clinical and Research Center
Bacterial Infection, Intensive Care
Impact of qSOFA Calculation on the Timing of Antimicrobial Therapy in the Emergency Department
The delayed administration of an adequate antimicrobial therapy is a strong predictor of impaired outcome in patients with bacterial sepsis.
- Trial name
- qSOFAST (NCT03299894)
- Testing
- systematic calculation of qSOFA
- Where
- France
- Volunteers
- 780 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Intensive Care Unit Acquired Weakness, Sepsis, Severe
Is NMES Treatment in Sepsis/ Septic Shock Patients Protective in Development of ICU-AW?
Background: Sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age.
- Trial name
- NCT04833621
- Testing
- NMES GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Ondokuz Mayıs University
Septic Shock
Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock
The aim of the study is to evaluate whether fluid responsiveness of the critically ill patient can be assessed by analysing the PEEP-induced hemodynamic effects to systolic blood pressure, pulse pressure, aortic blood flow…
- Trial name
- NCT01827007
- Testing
- Volume expansion with gelofusine
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Hyperlactatemia
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients
The study aimed to assess the effectiveness of intravenous thiamine as compared with placebo in reducing the lactate level in septic shock patients.
- Trial name
- NCT03649009
- Testing
- Normal Saline, Thiamine, Hydrocortisone
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Coagulation Disorder, COVID 19 Associated Coagulopathy
Coagulation Disturbances in COVID-19 Septic Patients
Objective of this study was to determine the relationship between CAC and septic condition in COVID-19 critically ill patients. Data including age, sex, comorbidities, quick Sequential Organ Failure Assessment (qSOFA) score…
- Conditions
- Coagulation Disorder, COVID 19 Associated Coagulopathy, Sepsis, Septic Shock
- Trial name
- NCT05496816
- Testing
- CAC in septic patients
- Where
- Bosnia and Herzegovina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital Zenica
Resolution of Septic Shock With Terlipressin
Terlipressin Alone Versus the Standard Therapy With Catecholamines for Hepatic Patients With Septic Shock- Prospective Single Center Randomized Controlled Study.
The purpose of this study is to evaluate the use of terlipressin compared to standard regimen in hepatic patients with septic shock. Another aim is to compare the mortality rate \& the effects on renal functions in both groups.
- Trial name
- NCT03608514
- Testing
- Experimental
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Infections, Sepsis
Can Measurement of Neutrophil-derived ROS Production be a Novel Biomarker of Sepsis?
Neutrophils are indispensable for host defense and have an important roles in modulating the immune system in both the innate and adaptive immune response.
- Conditions
- Infections, Sepsis, Septic Shock
- Trial name
- LIT-sepsis (NCT05968287)
- Testing
- The Leukocyte ImmunoTest™ (LIT™)
- Where
- Turkey (Türkiye)
- Volunteers
- 276 people
- Sponsor
- Gazi University
Severe Sepsis
Lotta Alla Sepsi Ospedaliera - Fighting Hospital Sepsis
Sepsis is widespread (1.8 million cases annually worldwide) and accounts for a very high mortality: 20-25% of all severe sepsis, 40-70% of all septic shock.
- Trial name
- NCT01804764
- Where
- Italy
- Volunteers
- 1,123 people
- Sponsor
- University of Milano Bicocca
Septic Shock, Echocardiography Guided Fluid Management
Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography
The goal of this study is to evaluate the role of carotid Doppler and Echocardiography as a predictor of fluid responsiveness in paediatric patients with septic shock.
- Trial name
- NCT07136532
- Testing
- echocardiography
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Septic Abortion
Prolonged Treatment for Infected Abortion After Hospital Discharge.
Patients with infected abortion will be treated with dilatation and curettage, intravenous antibiotics. The purpose of this study is to verify if it is necessary to keep the use of oral antibiotics after hospital discharge.
- Trial name
- APA (NCT00376493)
- Testing
- metronidazole and doxycycline
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
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