Clinical trials: Septic
Severe Sepsis or Septic Shock, Fluid Resuscitation
COrporeal Compression at the ONset of Severe Sepsis and Septic Shock
Early and adequate fluid resuscitation (< 6 hours) in patients with circulatory failure is essential but may exacerbate oedema, which may itself: 1) aggravate pulmonary lesions and prolong mechanical ventilation, 2) aggravate…
- Trial name
- COCOON (NCT02656654)
- Testing
- Whole-body compression
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Respiratory Distress Syndrome, Adult, Septic Shock
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
57 patients with Adult Respiratory Distress Syndrome (ARDS) requiring Extracorporeal membrane oxygenation (ECMO) therapy were analyzed retrospectively.
- Trial name
- IVIG (NCT02961166)
- Testing
- IgM enriched Immunoglobulins
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Septic Shock
Observational Study on Intubation in Septic Shock
Septic shock is common in intensive care and its mortality remains high. While new treatments have not improved survival, optimization of known and widely used techniques has allowed reduction in mortality.
- Trial name
- INTUBATIC (NCT02780466)
- Volunteers
- 859 people
- Sponsor
- University Hospital, Angers
Severe Sepsis or Septic Shock
Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?
Many biomarkers have been evaluated in sepsis, especially for prognostic purposes, but none has yet been shown to have sufficient sensitivity or specificity for routine use in clinical practice.
- Trial name
- HEP-SEPSIS (NCT03682003)
- Testing
- blood diagnostic tests
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Rennes University Hospital
Septic Shock
Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-midazolam versus fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to hemodynamic status of…
- Trial name
- NCT03251170
- Testing
- Ketamine, Fentanyl, Midazolam
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Severe Sepsis or Septic Shock
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)
Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition.
- Trial name
- PITSTOP (NCT03068741)
- Testing
- Comparison 1: Prehospital Ceftriaxone, Comparison 2: Liberal fluids, Comparison 2: Conservative fluids
- Where
- 4 sites in Canada
- Volunteers
- 2,061 people
- Sponsor
- Dr. Damon Scales
Acute Renal Failure, Sepsis
Angiotensin in Septic Kidney Injury Trial
The purpose of this study is to determine the effect of a systemic infusion of angiotensin II on haemodynamics and urine output in critically ill patients with severe sepsis/septic shock and acute renal failure.
- Conditions
- Acute Renal Failure, Sepsis, Septic Shock
- Trial name
- ASK-IT (NCT00711789)
- Testing
- Angiotensin II
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Austin Health
Sepsis, Septic Shock
Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis
Prospective, experimental, longitudinal cohort study in septic patients treated at ER and ICU at General Hospital Zone 11 IMSS Piedras Negras Coahuila.
- Trial name
- NCT04197115
- Testing
- Vitamin C, Hydrocortisone, Complex B
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- IMSS Hospital General de Zona 11, Piedras Negras
Septic Shock
A Trial of Vitamin B12 in Septic Shock
This study will randomize 20 septic shock patients to receive either a single 5 gram dose of IV vitamin B12 (Cyanokit® Meridian Medical Technologies, Columbia, MD) versus placebo in addition to standard of care to test the…
- Trial name
- B12 (NCT03783091)
- Testing
- Hydroxocobalamin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Morality, Sepsis
Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock
The aim of this study is to find the utility of red cell distribution width and lactate/albumin ratio as prognostic markers in sepsis and septic shock patients.
- Conditions
- Morality, Sepsis, Septic Shock
- Trial name
- NCT05921825
- Testing
- Red cell distribution width, lactate albumin ratio measurement
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Anemia, Sepsis
Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a Randomized Controlled Trial
Background Up to 66% of have anemia at the admission to the intensive care unit. This number increases to 95% after 72 hours of hospitalization in the intensive care unit due to illness and iatrogenic blood loss.
- Conditions
- Anemia, Sepsis, Septic Shock
- Trial name
- EpoAid (NCT06670963)
- Testing
- Iron, EPO, 0.9 % NaCl
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Piotr Czempik
Sepsis, Delirium
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive impairment in…
- Conditions
- Sepsis, Delirium, Impaired Cognition
- Trial name
- MENDS2 (NCT01739933)
- Testing
- Dexmedetomidine, Propofol
- Where
- 11 sites in United States
- Volunteers
- 438 people
- Sponsor
- Vanderbilt University Medical Center
Acute Kidney Injury, Sepsis
BAR As a Mortality Predictor in Septic AKI
The aim of this study is to investigate the prognostic value of Blood Urea Nitrogen to serum Albumin ratio in septic Acute Kidney Injury patients Follow-up will be conducted for all enrolled patients for 30 days from admission to…
- Trial name
- NCT06584149
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Septic Shock
The Effect of Midazolam on Fluid Responsiveness in Septic Patients
Fluid resuscitation remains the foundation for septic treatment.The evaluation of fluid responsiveness has significance in volume resuscitation for septic shock patients.
- Trial name
- NCT02050893
- Testing
- sedatives(Midazolam and Propofol)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Cardiac Output, LIDCO Rapid, Septic Shock
Validation of Uncalibrated Cardiac Output Measurement With LiDCOrapid in the Resuscitation of Critically Ill Patients With Septic Shock: A Prospective Cross-sectional Study.
Transthoracic echocardiography (TTE) has been used as a reference technique for CO measurement and its accuracy has been adequate for many clinical uses. TTE is painless, safe and non-invasive.
- Trial name
- NCT04705493
- Testing
- fluid resuscitation with crystalloid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Septic Shock
Heart Rate Control With Esmolol in Septic Shock
The purpose of this study is investigate the effects on systemic hemodynamics and organ function of esmolol when used to maintain heart rate below a predefined threshold in patients with septic shock.
- Trial name
- NCT01231698
- Testing
- esmolol, control
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Andrea Morelli
Sepsis
Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown.
- Trial name
- NCT00410111
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Basel, Switzerland
Shock, Septic
NOrepinephrine and VasoprEssin Versus Norepinephrine aLone in Critically Ill Patients With Septic Shock
Sepsis, a systemic host response to the invasion of a pathogenic microorganism, may progress to severe sepsis, wherein the patient experiences acute dysfunction in at least one organ system, and further develop into septic shock…
- Trial name
- NOVEL (NCT02454348)
- Testing
- Vasopressin, Norepinephrine
- Where
- United States
- Sponsor
- University of Arkansas
Septic Shock
Mortality Reduction in Septic Shock by Plasma Adsorption
The study objective is to clarify whether the application of high doses CPFA (Coupled Plasma-Filtration Adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in…
- Trial name
- ROMPA (NCT02357433)
- Testing
- High Doses CPFA
- Where
- 10 sites in Spain
- Volunteers
- 55 people
- Sponsor
- Francisco Colomina Climent
Septic Shock, Sepsis
Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock
Compare the effect of volume expansion by saline versus albumin on the correction of peripheral tissue hypoperfusion by measuring Index skin recoloration time (CRT) at H0 and H1
- Trial name
- REPTILOS (NCT05094856)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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