Clinical trials: Septic Acute Kidney Injury
Septic Shock, Acute Kidney Injury
Early Endotoxin Burden Reduction With oXiris in Septic Shock Patients Requiring CRRT
The goal of this clinical trial is to learn whether continuous renal replacement therapy (CRRT) using the oXiris filter can lower the amount of endotoxin in the blood of adults with septic shock who need CRRT.
- Trial name
- NCT07807410
- Testing
- oXiris Hemofilter
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Septic Shock
TIMP2*IGFBP7 and Transient AKI
Patients with septic shock in the intensive care unit have a high risk to develop acute kidney injury (AKI) and AKI is an independent risk factor of mortality.
- Trial name
- BIOCHECK (NCT03472079)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Kidney Injury, Septic Shock
Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?
Septic shock is one of the leading causes of death in patients admitted to the intensive care unit (ICU). Acute kidney injury (AKI) occurs in almost 50% of septic patients and is associated with significant mortality.
- Trial name
- HEMOCHECK (NCT03547414)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sepsis, Septic Shock
Safety and Feasibility of Metformin for Sepsis Induced AKI
Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury, Metformin
- Trial name
- NCT05900284
- Testing
- Metformin low dose, Metformin high dose
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hernando Gomez
Septic Shock, Acute Kidney Injury
Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study
Sepsis and septic shock are major causes of mortality in critically ill patients and are frequently associated with acute kidney injury requiring renal replacement therapy.
- Trial name
- NCT07569406
- Testing
- Oxiris filter, Standard Hemofilter
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Septic Shock, Cirrhosis
Comparison of Angiotensin II to Standard Dose Vasopressors on Change in Arterial Elastance
A study to see whether a medication called Angiotensin II works better than the routinely used medication to raise blood pressure in people with liver disease who are experiencing a serious drop in blood pressure.
- Conditions
- Septic Shock, Cirrhosis, Vasodilatory Shock, Acute Kidney Injury
- Trial name
- Ang2 (NCT07568275)
- Testing
- Giapreza
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Acute Kidney Injury
A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis)
Biomarkers that provide an early indicator of kidney stress could be useful in clinical practice to detect silent episodes of acute kidney injury (AKI) or for early identification of subjects at risk of AKI.
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock
- Trial name
- LAPIS (NCT04434209)
- Testing
- Subject management guided by NephroCheck® test, Standard of Care
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 19 people
- Sponsor
- BioMérieux
Septic Shock, Acute Kidney Injury
Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic Shock
Septic shock is a life-threatening condition that can cause severe circulatory failure and damage to vital organs, including the kidneys.
- Trial name
- NCT07418541
- Testing
- Norepinephrine, Crystalloid Fluid Resuscitation
- Volunteers
- 100 people
- Sponsor
- Universitas Sumatera Utara
Septic Shock, Acute Renal Failure (as Defined by the "Failure" Stage of the RIFLE Classification)
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)
The purpose of this multicentric, randomized controlled trial is to assess whether the timing of renal replacement therapy initiation (early vs delayed) has an impact on mortality at 90 days in patients with severe acute kidney…
- Trial name
- IDEAL-ICU (NCT01682590)
- Testing
- Renal Remplacement Therapy
- Where
- 27 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Severe Sepsis, Shock, Septic
L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury
The primary objective of this study is to compare 28 day mortality rates between septic shock patients with acute renal insufficiency treated via L-Carnitine (as an adjunct therapy) versus a similar group of patients not…
- Conditions
- Severe Sepsis, Shock, Septic, Acute Kidney Injury
- Trial name
- CarniSave (NCT02664753)
- Testing
- 56 days of weight-adjusted L-Carnitine treatment
- Where
- 11 sites in France
- Volunteers
- 254 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury, Septic Shock
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting.
- Conditions
- Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality
- Trial name
- VITAKI (NCT04589546)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Kidney Injury, Septic Shock
Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.
The development of acute kidney injury (AKI) during septic shock is frequent and is associated with a high mortality rate. The reason of this increased mortality despite the use of renal replacement therapy is still unknown.
- Conditions
- Acute Kidney Injury, Septic Shock, Uremic; Toxemia, Mortality
- Trial name
- TOX-AKI (NCT03920982)
- Testing
- Determination of the blood concentration of indoxyl sulfate (IS)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock, Acute Kidney Injury
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal…
- Trial name
- REPERFUSE (NCT06234592)
- Testing
- Angiotensin II, Vasopressin, Norepinephrine
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College Hospital NHS Trust
Sepsis, Septic Shock
Impact of Prior SGLT2 Inhibitors Use on the Development and Progression of Sepsis-Associated Acute Kidney Injury
The primary objective of this study is to investigate whether using SGLT2i may be associated with decreased incidence of sepsis-induced AKI or not.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT06902493
- Testing
- No intervention
- Where
- Saudi Arabia
- Volunteers
- 664 people
- Sponsor
- University of Jazan
Sepsis, Septic Shock
The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients
This clinical trial aims to evaluate the effect of dexmedetomidine in Sepsis-Associated Acute Kidney Injury in critically ill patients by answering the following questions: 1.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT06570187
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Cairo University
Septic Shock, Acute Kidney Injury
Renin and Renal Biomarker Response to Angiotensin II
Septic shock continues to exert a large economic burden around the world. Several developments have occurred that lead to the current study.
- Trial name
- NCT04558359
- Testing
- Standard of Care, Angiotensin II
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexander Flannery
Septic Shock, Abdominal Sepsis
OXiris for Abdominal SEptic Shock (OASES Study)
This study innovatively utilizes multi-modal hemodynamic monitoring (Norepinephrine equivalence, NEE+Pulse indicator Continuous Cariac output, PiCCO) to investigate the optimal timing of initiation of oXiris in abdominal…
- Conditions
- Septic Shock, Abdominal Sepsis, Multi Organ Failure, Blood Purification
- Trial name
- OASES (NCT06504316)
- Testing
- CRRT filter
- Where
- China
- Volunteers
- 192 people
- Sponsor
- RenJi Hospital
Acute Kidney Injury, Septic Shock
RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock
Acute kidney injury (AKI) is a common complication in critically ill patients. Multiple studies have reported evidence that the main cause of ARF is sepsis, as part of the Multiple Organ Dysfunction Syndrome: up to 50% of septic…
- Trial name
- NCT04952714
- Testing
- Oxiris
- Where
- Colombia
- Volunteers
- 93 people
- Sponsor
- Clinica CES