Clinical trials: Septicemic Shock
Septic Shock
Low Dose Versus High Dose Methylene Blue in Septic Patients
The main aim of this study is to examine the various effects of continuous methylene blue infusion in septic cancer patients and to compare it with the traditional infusion of noradrenaline in such patients .
- Trial name
- NCT06005558
- Testing
- Normal saline, Methylene Blue low dose, Methylene Blue high dose
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Sepsis, Severe
Vitamin C, Vitamin B1 and Steroid in Sepsis
A randomized controlled trial to test the synergic modulation effect of vitamin C, thiamine and hydrocortisone in patients with severe sepsis or septic shock.
- Trial name
- NCT04039815
- Testing
- Ascorbic acid-Vitamin B1-Hydrocortisone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far Eastern Memorial Hospital
Septic Shock
Protocolised Early De-Resuscitation in Septic Shock (REDUCE)
Background: Recent studies have questioned the safety of current fluid resuscitation strategies in patients with septic shock as prospective and observational data suggesting that the resulting fluid overload is associated with…
- Trial name
- REDUCE (NCT04931485)
- Testing
- Fluid management according to the REDUCE Fluid Protocol, Standard of care
- Where
- 4 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock, Critical Illness
Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock
Despite recent medical advances, sepsis and septic shock remain a major cause of death. Sepsis is a syndrome with a wide array of physiologic, pathologic, and biochemical abnormalities.
- Trial name
- HYVITS (NCT03380507)
- Testing
- Triple therapy group
- Where
- Qatar
- Volunteers
- 106 people
- Sponsor
- Hamad Medical Corporation
Septic Shock
Lipopolysaccharide Adsorption At Septic Shock
Sepsis is a global healthcare burden sepsis, it reaches 20-30 million cases annually (WHO data). Numerous studies have shown that extracorporeal hemoperfusion therapies that eliminate endotoxin and\or excess of cytokines improve…
- Trial name
- LASSO (NCT04827407)
- Testing
- Efferon LPS hemoperfusion
- Where
- 4 sites in Russia
- Volunteers
- 58 people
- Sponsor
- Efferon JSC
Shock, Septic, Hyperlactatemia
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
The MostCare system, thanks to the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy), provides new hemodynamic parameters of the cardiovascular system.
- Conditions
- Shock, Septic, Hyperlactatemia, Oliguria, Aortic Aneurysm, Abdominal
- Trial name
- RELASTANCE (NCT04388267)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis, Children, Only
Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children
The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored.
- Trial name
- NCT04794595
- Testing
- CBP
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Children's Hospital of Fudan University
Septic Shock
Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis
The incidence of sepsis (severe infection) has increased over the last four decades. Severe sepsis and septic shock are among the leading causes of death for patients admitted to critical care units with mortality ranging from…
- Trial name
- NCT04057872
- Testing
- Therapeutic plasma exchange
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Alberta Health Services, Calgary
Septic Shock
Glycosaminoglycans During Septic Shock - a Temporal Study
We have previously shown that the plasma level of glycosaminoglycans (GAG) in septic shock patients are elevated compared to controls.
- Trial name
- GAGS (NCT00814112)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Region Skane
Pregnancy, Postpartum
Organ Dysfunction Score for Obstetric Patients
The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorporates a non-invasive tool to evaluate respiratory function (pulse…
- Conditions
- Pregnancy, Postpartum, Organ Dysfunction, Critical Care, Intensive Care
- Trial name
- SOFA-OBS (NCT07068022)
- Testing
- Organ dysfunction score adjusted to obstetric patients (SOFA-OBS)
- Where
- 18 sites in Argentina, Ecuador and 2 more
- Volunteers
- 130 people
- Sponsor
- Daniela Vasquez
Neonatal Sepsis, Shock, Septic
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Preterm infants (born at less than 37 weeks of pregnancy) sometimes develop a serious blood infection leading to low blood pressure, which does not respond to saline or to the standard medicines for increasing blood pressure…
- Trial name
- NCT06306001
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Septic Shock
Severe Septic Shock Complications
Adults older than 18 years old, admitted to the ICU with a Severe Septic Shock, requiring Norepinephrine at more than 0.25mcg/kg/min, who have signed informed consent form, will be consecutively included, from december 2018 to…
- Trial name
- NCT03716895
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Septic Shock, Septicemia
Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock
Septic shock is a clinical condition that is defined as a subset of sepsis that causes very high mortality and morbidity. Surviving sepsis campaign guideline states that the target mean arterial pressure should be 65 mmHg and…
- Conditions
- Septic Shock, Septicemia, Intraabdominal Hypertension, Renal Injury
- Trial name
- NCT05358912
- Testing
- Vasopressor Agent, Crystalloid Solutions, Invasive Blood Pressure Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Bozyaka Training and Research Hospital
Critically Ill Patients, Septic Shock
Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase
It is well recognized the association between fluid volume administered and positive fluid balance with adverse outcomes . Active fluid removal is widely practiced in an attempt to mitigate this potential damage.
- Trial name
- VEXUS (NCT06227702)
- Testing
- Fluid management according to Venous Excess Ultrasound (VExUS) Score
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
Septic Shock, Sepsis
VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients
This study is being conducted to evaluate the safety and effectiveness of VBI-S in elevating the blood pressure of septic shock patients with absolute or relative hypovolemia.
- Conditions
- Septic Shock, Sepsis, Hypovolemia
- Trial name
- NCT04257136
- Testing
- VBI-S
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Vivacelle Bio
Critical Illness, Acute Kidney Injury
Collective Accuryn Physiologic Signals and Signatures
The CAPSS Study is a retrospective and prospective, multi-center, single-arm post-market data collection study with an FDA cleared device.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Septic Shock
- Trial name
- CAPSS (NCT03817281)
- Testing
- Accuryn Monitoring System
- Where
- United States
- Sponsor
- Potrero Medical
Hyperlactatemia
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients
The study aimed to assess the effectiveness of intravenous thiamine as compared with placebo in reducing the lactate level in septic shock patients.
- Trial name
- NCT03649009
- Testing
- Normal Saline, Thiamine, Hydrocortisone
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Septic Shock, Fungal Infection
Pharmacokinetics of Caspofungin
The objective of this study is to describe the pharmacokinetics of standard doses of caspofungin in critically ill patients.
- Conditions
- Septic Shock, Fungal Infection, Critical Illness
- Trial name
- NCT03399032
- Testing
- Caspofungin
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Medical University of Lublin
Severe Sepsis, Septic Shock
Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock
Severe sepsis and septic shock are diseases of infectious origin with a high risk of death. Antibiotic therapy is mandatory but it is unknown whether one antibiotic alone is sufficient for initial therapy.
- Trial name
- MaxSep (NCT00534287)
- Testing
- meropenem, meropenem, moxifloxacin
- Where
- 52 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Kompetenznetz Sepsis
Sepsis, Septic Shock
Nasal and Gut Microbiota Combined Clinical Events Predicts the Prognosis of Septic Patients
In this prospective, multicentered , diagnostic trial, nasal and fecal specimens will collected from patients with sepsis in two critical care units(ICU) at the enrollment day ,the third, seventh, and fourteen days after…
- Trial name
- NCT05143736
- Testing
- gut and nasal microbiota detection
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Zhujiang Hospital
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