Clinical trials: Septicemic Shock
Septic Shock
Norepinephrine Equivalent Dose of Vasopressin, Phenylephrine and Epinephrine in Septic Shock
Septic shock is the most common form of circulatory shock encountered in patients admitted in intensive care unit. The initial management involves fluid resuscitation but if hypotension does not get resolved solely by it, then…
- Trial name
- NCT06499467
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Shock, Septic, Sepsis
Anticholium® Per Se
Anticholium® per Se is a randomized, double-blind, placebo-controlled, monocentric trial to assess whether the CAP can be transferred from bench to bedside.
- Conditions
- Shock, Septic, Sepsis, Perioperative Period
- Trial name
- NCT03013322
- Testing
- Physostigmine, Isotonic Saline
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Severe Sepsis
ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis
The purpose of this study is to compare eritoran tetrasodium and placebo in patients with severe sepsis and to demonstrate a reduction of mortality from all causes.
- Trial name
- NCT00334828
- Testing
- eritoran tetrasodium
- Where
- 251 sites in United States, Argentina and 22 more
- Volunteers
- 2,000 people
- Sponsor
- Eisai Inc.
Septic Shock, Delirium
Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.
- Conditions
- Septic Shock, Delirium, Renal Failure
- Trial name
- NCT01836302
- Testing
- Observation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Manitoba
Septic Shock, Coagulopathy
Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study
No randomized controlled trial (RCT) has investigated the effect of prophylactic fresh frozen plasma (FFP) transfusion in septic or critically ill patients with coagulation abnormalities.
- Conditions
- Septic Shock, Coagulopathy, Disseminated Intravascular Coagulation
- Trial name
- PlasmaFaisa (NCT04580563)
- Testing
- OctaplasLG®, 0.9% NaCl
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Septic Shock
The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation
The primary aim of this study is to evaluate the 30-day mortality outcome of the septic shock patients who are treated with ultrasound-assisted fluid management using change of the inferior vene cava (IVC) diameter during…
- Trial name
- NCT03020407
- Testing
- IVC Ultrasound-guided, Antibiotics, Vasopressor
- Where
- Thailand
- Volunteers
- 211 people
- Sponsor
- Chulalongkorn University
Hypotension, Shock, Septic
Midodrine During Recovery From Septic Shock
The purpose of this study is to determine whether midodrine administration decreases duration of intravenous vasopressors and intensive care unit length of stay for patients in septic shock.
- Conditions
- Hypotension, Shock, Septic, Sepsis
- Trial name
- NCT02771158
- Testing
- Midodrine
- Sponsor
- Northwell Health
Sepsis
Safety of Heparin in Patients With Septic Shock
Sepsis is a syndrome comprised of a systemic inflammatory response, signs of tissue hypoperfusion, and organ in the setting of presumed infection.
- Trial name
- NCT01234285
- Testing
- heparin
- Where
- United States
- Sponsor
- University of Colorado, Denver
Central Oxygen Saturation, Microcirculation
Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients
Mottling score and central venous oxygen saturation are described as a clinical evaluation of tissue perfusion. This study describes mottling incidence and mottling score in septic shock patients according to central venous…
- Conditions
- Central Oxygen Saturation, Microcirculation, Mottling Score, Septic Shock
- Trial name
- NCT05681052
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Erzincan University
Shock, Septic
Comparison of Vasopressin and Other Pressors in Septic Shock
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
- Trial name
- NCT00269685
- Testing
- vasopressin
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Sepsis, Septic Shock
Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter Study
To evaluate the value of biomarkers of neuronal and glial injury for predicting cognitive impairment (memory impairment assessed by a MoCA score < 26/30) at 3 months in patient admitted in the intensive care unit for a sepsis or…
- Trial name
- SEPSYM (NCT07746050)
- Testing
- Serum
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic Shock
Esomeprazole to Reduce Organ Failure in Sepsis
Sepsis is a severe disease with a high mortality rate and lack of efficacious therapies. Proton pump inhibitors (PPI) are drugs widely used to inhibit acid secretion by gastric cells and with a high safety profile.
- Trial name
- PPI-SEPSIS (NCT03452865)
- Testing
- Esomeprazole
- Where
- 17 sites in Italy, Kazakhstan and 1 more
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Critical Care, Cancer
Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock
De-escalation aims at reducing the use of broad-spectrum antibiotics and therefore the emergence of multidrug-resistant (MDR) pathogens. Observational studies suggested that this strategy seems to be safe.
- Trial name
- DéPOH (NCT03683329)
- Testing
- Antibiotic de-escalation, Standard treatment
- Where
- France
- Volunteers
- 398 people
- Sponsor
- Institut Paoli-Calmettes
Septic Shock
Lipopolysaccharide Adsorption At Septic Shock
Sepsis is a global healthcare burden sepsis, it reaches 20-30 million cases annually (WHO data). Numerous studies have shown that extracorporeal hemoperfusion therapies that eliminate endotoxin and\or excess of cytokines improve…
- Trial name
- LASSO (NCT04827407)
- Testing
- Efferon LPS hemoperfusion
- Where
- 4 sites in Russia
- Volunteers
- 58 people
- Sponsor
- Efferon JSC
Severe Sepsis, Septic Shock
Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations.
- Trial name
- NCT01332734
- Testing
- Magnesium Sulfate
- Where
- Lithuania
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Septic Shock Hyperdynamic
Acetated Ringer's Solution Versus Saline in Patients With Septic Shock
The primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients.
- Trial name
- NCT04507672
- Testing
- Fluid resuscitation
- Volunteers
- 2,000 people
- Sponsor
- Southeast University, China
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Septic Shock, Hypotension
Esmolol to Treat the Hemodynamic Effects of Septic Shock
The main purpose of this study is to determine the effects of controlling the heart rate of patients with septic shock using an intravenous medication called esmolol.
- Conditions
- Septic Shock, Hypotension, Tachycardia
- Trial name
- NCT02369900
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sepsis, Severe, Septic Shock
High-dose Intravenous Vitamin C in Patients With Septic Shock
Despite promising observational and phase 1 data, the therapeutic potential of vitamin C for the management of septic shock has not borne out in recent large multi-centre randomized controlled trials.
- Trial name
- HIGH-VIS (NCT04796636)
- Testing
- Sodium Ascorbate
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Septic Shock, Sepsis
Examination of ADMA Serum Level and DDAH II
Examination of ADMA (Asymmetric-Dimethylarginine)-serum level and DDAH II (Dimethylarginine Dimethylaminohydrolase)- Polymorphism in patients with severe Sepsis and septic shock as prognostic value.
- Trial name
- ADSeS (NCT01632059)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
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