Clinical trials: Serotonin Deficiency
Depression - Major Depressive Disorder
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression
Clinical depression is a common and disabling condition characterised by persistent low mood and loss of interest that interferes with daily functioning.
- Trial name
- FenDep (NCT07651293)
- Testing
- Fenfluramine Hydrochloride, [11C]Cimbi-36
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Oculocutaneous Albinism
Peripheral Serotonin and Albinism
Serotonin (5-HT or 5-hydroxytryptamine) is a monoamine primarily known for its role as a neurotransmitter in the central nervous system (CNS).
- Trial name
- SEPIAs (NCT06138509)
- Testing
- Dosage of serotonin and metabolites, Blood parameters
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Iron Deficiency, Fibromyalgia
Frequency and Impact of Iron Deficiency in Pain Clinic Patients
The goal of this study is to measure the proportion of patients who have iron deficiency and if iron deficiency is treated what is the outcome.
- Trial name
- NCT06665516
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- McMaster University
Idiopathic SSNHL, Age Over 18
Blood Markers in Adult Patients With Sudden Sensorineural Hearing Loss (SSNHL)
The roles of thrombophilia and cardiovascular risk factors in sudden sensorineural hearing loss (SSNHL) remain controversial. Cochlear micro-thrombosis has been hypothesized as a possible pathogenic mechanism of SSNHL.
- Trial name
- SSNHL (NCT03919474)
- Testing
- microvascular markers
- Where
- France
- Volunteers
- 394 people
- Sponsor
- Hopital Lariboisière
Depression, Serotonin Deficiency
Human Cerebral Blood Flow and Serotonin
Breathing, blood pressure, and blood flow into the brain are controlled - in part - by small areas in the brainstem; the central chemoreceptors.
- Trial name
- NCT05957094
- Testing
- Pharmacological agent: Citalopram
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of British Columbia