Clinical trials: Serrated Adenomas
Colorectal Neoplasms, Intestinal Neoplasms
Usefulness of GI-GENIUS in FIT-based Colorectal Cancer Screening Program.
Deep learning technology has an increasing role in medical image applications and, recently, an artificial intelligence device has been developed and commercialized by Medtronic for identification of polyps during colonoscopy…
- Conditions
- Colorectal Neoplasms, Intestinal Neoplasms, Gastrointestinal Neoplasms, Colonic Polyp
- Trial name
- CADILLAC (NCT04673136)
- Testing
- GI-GENIUS Medtronic, Colonoscopy
- Where
- 6 sites in Spain
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Asociación Española de Gastroenterología
Serrated Lesion, Adenoma
Serrated Lesions Detection With Endocuff-assisted Colonoscopy
Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide, especially in Western countries. CRC is currently considered a preventable disease and screening has been endorsed by several societies, since it…
- Conditions
- Serrated Lesion, Adenoma, Colorectal Cancer
- Trial name
- NCT03856957
- Testing
- Endocuff colonoscopy, control
- Where
- Portugal
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Adenoma Colon, Serrated Adenoma
Does Inspection of Colonic Mucosa During Insertion Improve Adenoma Detection?
This is a prospective randomised controlled trial to assess an intervention of inspection during both phases of colonoscopic examination ( insertion and withdrawal) improve adenoma detection rate when compared to inspection only…
- Trial name
- INWARD (NCT03254030)
- Testing
- Colonic inspection
- Where
- United Kingdom
- Volunteers
- 490 people
- Sponsor
- London North West Healthcare NHS Trust
Colorectal Neoplasm, Colorectal Cancer
Colorectal Cancer Screening Using Stool DNA-based SDC2 and SFRP2 Methylation Test in China
The primary objective is to determine sensitivity, specificity, positive predictive value and negative predictive value of a bi-target stool DNA testing (the methylation status of SDC2 and SFRP2) for colorectal cancer and…
- Conditions
- Colorectal Neoplasm, Colorectal Cancer, Adenomatous Polyps, Adenoma
- Trial name
- NCT04515082
- Testing
- Stool-based SDC2 and SFRP2 DNA methylation test, FIT
- Volunteers
- 4,800 people
- Sponsor
- Changhai Hospital
Colorectal Serrated Adenomas, Colorectal Tubular Adenomas
Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE-
This is a randomized, placebo controlled, multicentric trial to investigate the effect of diet supplementation with green tea extract containing 300mg epigallocatechin gallate (EGCG), the major polyphenol of green tea, on the…
- Conditions
- Colorectal Serrated Adenomas, Colorectal Tubular Adenomas, Colorectal Villous Adenomas, Colorectal Tubulovillous Adenomas
- Trial name
- MIRACLE (NCT01360320)
- Testing
- Green tea extract of Camellia Sinensis
- Where
- 21 sites in Germany
- Volunteers
- 1,001 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Colon Polyp, Adenoma Colon
AmplifEYE Colonoscopy vs Standard Colonoscopy
Colonoscopy screening is proven to reduce mortality rates for colorectal cancer, which relies on early detection and removal of colonic polyps.
- Conditions
- Colon Polyp, Adenoma Colon, Serrated Polyp, Colonic Neoplasms
- Trial name
- NCT03814369
- Testing
- AmplifEYE
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Sessile Serrated Adenoma/Polyps
Usefulness of NBI for Complete Endoscopic Resection of SSA/P
This study is a prospective randomized study to evaluate the role of NBI for improving complete resection rate of sessile serrated adenoma/polyp (SSA/P).
- Trial name
- NCT03761667
- Testing
- Endoscopy using Narrow band imaging
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Colon Cancer, Colon Sessile Serrated Adenoma/Polyp
Narrow Band Imaging Versus White Light for Colonoscopy Serrate Lesions Detection
Colorectal cancer (CRC) is a leading cause of cancer death and its' incidence is rising in most European countries. Colonoscopy has been shown to reduce CRC incidence, however its effectiveness depends on the sensitivity to…
- Trial name
- NCT02876133
- Testing
- narrow band imaging withdrawal, white light withdrawal
- Where
- 3 sites in Portugal
- Volunteers
- 987 people, healthy volunteers welcome
- Sponsor
- Hospital Beatriz Ângelo
Colon Adenoma, Colorectal Carcinoma
NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum
Adenomas, serrated adenomas and hyperplastic polyps are polypoid lesion in the colorectum. At the present moment, all polyps should be resected endoscopically, although only adenomas and serrated adenomas, but not hyperplastic…
- Conditions
- Colon Adenoma, Colorectal Carcinoma, Hyperplastic Polyp, Serrated Adenoma
- Trial name
- ADOPTION II (NCT03679429)
- Testing
- NBI Function
- Where
- 3 sites in Germany
- Volunteers
- 370 people
- Sponsor
- Technical University of Munich
Serrated Polyp, Hyperplastic Polyp
Study of Gut Microbiome and Colorectal Tumors
Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
- Conditions
- Serrated Polyp, Hyperplastic Polyp, Sessile Serrated Adenoma, Colorectal Cancer
- Trial name
- NCT03297996
- Testing
- Mobio PowerSoil DNA Isolation Kit
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- NYU Langone Health
Colonic Neoplasms, Adenomas Serrated
Detection in Tandem Endocuff Cap Trial
A randomised back to back study comparing cap and Endocuff to detect adenomas during colonoscopy
- Conditions
- Colonic Neoplasms, Adenomas Serrated, Colo-rectal Cancer, Colon Adenoma
- Trial name
- DETECT (NCT03254498)
- Testing
- Endocuff, cap assisted colonoscopy (CAC)
- Where
- United Kingdom
- Volunteers
- 154 people
- Sponsor
- London North West Healthcare NHS Trust
Colorectal Sessile Serrated Adenomas/Polyps
The Real-time Optical Diagnosis Value of Optical Enhancement Endoscopy in Colorectal Sessile Serrated Adenomas/Polyps
When a polyp is found, we begin to wash it and observe it with OE mode 1.Then,the endoscopist gives a real-time optical diagnosis and the future surveillance interval.Finally,the polyp will be resected for the biopsy.
- Trial name
- NCT03238573
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University
Serrated Polyps, Sessile Serrated Adenoma
Study of Narrow Band Imaging in the Characterization of Serrated Lesions
This study is designed to evaluate the utility of Narrow Band Imaging (NBI) compared with High Definition White Light colonoscopy (WLE) in subjects with serrated lesions who do not fulfill the diagnostic criteria of Serrated…
- Conditions
- Serrated Polyps, Sessile Serrated Adenoma, Colorectal Neoplasms
- Trial name
- CROMOSER (NCT02406547)
- Testing
- NBI, WLE
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Parc de Salut Mar
Colorectal Cancer, Serrated Adenomas
Acetic Acid Colonoscopy Enhancement Study
The purpose of this study is to compare the additional diagnostic yield obtained by using the acetic acid as vital substance to improve the detection of serrated lesions at colonoscopy.
- Conditions
- Colorectal Cancer, Serrated Adenomas, Colon Nos Polypectomy Tubular Adenoma
- Trial name
- NCT02231385
- Testing
- Acetic Acid
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas