Clinical trials: Serrated Polyp
Colorectal Cancer
Clinical Validation of Polydeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System
This study is a clinical validation of Polydeep, a computer-aided polyp detection (CADe) and characterization (CADx) system. Polydeep Advance 1 is an unicentric prospective diagnostic tests trial with a paired study design.
- Trial name
- NCT05514301
- Testing
- Sensitivity of Polydeep vs high experienced endoscopists for colorectal polyp detection
- Where
- Spain
- Volunteers
- 205 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Colorectal Adenoma, Sessile Serrated Lesion
Evaluation of 'WAYMED Endo CL CS' for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions
The purpose of this clinical trial is to evaluate the effectiveness of the computer-aided diagnosis (CADx) software, 'WAYMED endo CL CS', which assists medical specialists by automatically analyzing colorectal endoscopic images…
- Conditions
- Colorectal Adenoma, Sessile Serrated Lesion, Hyperplastic Polyp, Carcinoma
- Trial name
- NCT07470827
- Testing
- WAYMED endo CL CS, Reference standard review
- Where
- South Korea
- Volunteers
- 1,178 people
- Sponsor
- WAYCEN Inc
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colon Polyp, Adenoma Colon
AmplifEYE Colonoscopy vs Standard Colonoscopy
Colonoscopy screening is proven to reduce mortality rates for colorectal cancer, which relies on early detection and removal of colonic polyps.
- Conditions
- Colon Polyp, Adenoma Colon, Serrated Polyp, Colonic Neoplasms
- Trial name
- NCT03814369
- Testing
- AmplifEYE
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Colon Polyp, Adenoma
Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection
The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.
- Conditions
- Colon Polyp, Adenoma, Serrated Polyp, Recurrence, Local Neoplasm
- Trial name
- STARLING (NCT07198945)
- Testing
- 6-month follow-up, 12-month follow-up
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 546 people
- Sponsor
- Indiana University
Colonic Polyp, Colonic Sessile Serrated Lesion
The CARMA Technique Study
Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers…
- Trial name
- NCT05099432
- Testing
- CARMA technique
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Colon Adenomas, Colon Polyps
Impact of Computer-aided Detection System on the Right Colon Adenoma Miss Rate
This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem…
- Conditions
- Colon Adenomas, Colon Polyps, Sessile Serrated Lesion
- Trial name
- NCT07308743
- Testing
- Computer-aided detection-assisted colonoscopy, Conventional white-light colonoscopy
- Where
- China
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Polyps, Adenoma Colon
Computer Assisted Selection of Serrated Adenomas and Neoplastic Polyps - a New Clinical DRAft
The aim of the study is to develop a computer program which is able to classify different entities of colorectal polyps on the basis of optical polyp features.
- Conditions
- Polyps, Adenoma Colon, Automatic Judgement, Colonic Neoplasms
- Trial name
- CASSANDRA I (NCT03550625)
- Testing
- Computer program
- Volunteers
- 300 people
- Sponsor
- Technical University of Munich
Colorectal Neoplasms, Colorectal Polyp
MS Versus NICE for Colorectal Lesions
OBJECTIVE: Our study aimed to compare a recently-developed endoscopic classification with an established one for colorectal lesions in a randomised trial between 2013 and 2015.
- Trial name
- NCT02963207
- Testing
- Modified Sano's classification, NICE classification
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Lyell McEwin Hospital
Sessile Serrated Lesion
Polyp Pretreatment Device for SSL Diagnosis
Colorectal cancer (CRC) is the third most common malignancy globally. Sessile serrated lesions (SSLs) account for 15-30% of CRC via the serrated pathway.
- Trial name
- NCT07601230
- Testing
- Polyp Pretreatment Device
- Volunteers
- 1,156 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sessile Colonic Polyp, Serrated Lesion
Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions
The goal of this clinical trial is to compare the detection rate of clinically significant serrated lesions (CSSL) in participants undergoing water exchange (WE) colonoscopy with artificial intelligence (AI)-based computer-aided…
- Conditions
- Sessile Colonic Polyp, Serrated Lesion, Sessile Serrated Lesion, Colon Adenomas
- Trial name
- NCT07127471
- Testing
- Water exchange with AI-assisted detection, Water exchange with AI-assisted detection and LCI
- Where
- 4 sites in Canada, Italy and 2 more
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Colorectal Cancer
Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 2.
This study is a clinical validation of PolyDeep, a computer-aided polyp detection (CADe) and characterization (CADx) system. PolyDeep Advance 2 is a multicentric randomized clinical trial with a tandem colonoscopy design.
- Trial name
- NCT05512793
- Testing
- Standard technique First colonoscopy without PolyDeep, Combination technique First colonoscopy with PolyDeep
- Where
- 3 sites in Spain
- Volunteers
- 260 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Adenoma Colon Polyp, Sessile Serrated Adenoma
The Impact of a Colonoscopy Monitoring Program on Endoscopists' Performance
The goal of this clinical trial is to learn if colonoscopy monitoring program works to adenoma detection rate in endoscopists. It will also learn about the impact on sessile serrated lesion detection rate, adenomas per…
- Trial name
- NCT06577610
- Testing
- Feedback from colonoscopy monitoring program
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Serrated Polyp, Hyperplastic Polyp
Study of Gut Microbiome and Colorectal Tumors
Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
- Conditions
- Serrated Polyp, Hyperplastic Polyp, Sessile Serrated Adenoma, Colorectal Cancer
- Trial name
- NCT03297996
- Testing
- Mobio PowerSoil DNA Isolation Kit
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- NYU Langone Health
Serrated Polyp
Serrated Polyp Detection Rate Between Carbon Dioxide and Air Insufflation
Sessile serrated adenomas are characterized by their flat shape and the presence of a yellow mucus cap overlying the lesion. These morphological features may account for their diagnostic difficulty during colonoscopy.
- Trial name
- NCT03623906
- Testing
- Carbon dioxide insufflation colonoscopy, Air insufflation colonoscopy
- Volunteers
- 1,280 people
- Sponsor
- The Catholic University of Korea
Adenoma, Colonoscopy
Effect of Two Colonoscopy AI Systems for Colon Polyp Detection
Computer-aided detection (CADe) systems have been actively researched for polyp detection in colonoscopy. The investigators aim to identify the effect of two CADe systems according to the system performance on false positive rate
- Conditions
- Adenoma, Colonoscopy, Sessile Serrated Adenoma
- Trial name
- NCT05089071
- Testing
- Assist by artificial intelligence system for colon polyp detection
- Where
- South Korea
- Volunteers
- 3,046 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Serrated Polyp, Colorectal Neoplasms
Increasing Serrated Polyp Detection With a Brief Awareness Training
In this non-randomized controlled trial, a semi-random group of Dutch endoscopist receive an oral training about the significance of serrated polyps.
- Trial name
- NCT03902899
- Testing
- Educational intervention (oral presentation)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colonic Polyp, Colonic Neoplasms
Chromoendoscopy for Serrated Polyposis Syndrome
Serrated polyposis syndrome (SPS) is the most common colorectal polyposis syndrome and is characterized by the combination of large and/or numerous serrated lesions (SLs) throughout the colorectum.
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Cancer
- Trial name
- SERRADA (NCT03476434)
- Testing
- chromoendoscopy with indigo carmine
- Volunteers
- 86 people
- Sponsor
- Hospital Universitario de Móstoles
Colorectal Cancer, Adenoma
Cold Snare Polypectomy Versus Endoscopic Mucosal Resection for Colonic Sessile Serrated Polyps
Comparing the efficacy of cold snare polypectomy with endoscopic mucosal resection
- Trial name
- CSP-EMR (NCT02967107)
- Testing
- Cold snare polypectomy, Endoscopic mucosal resection
- Where
- Australia
- Volunteers
- 474 people
- Sponsor
- Western Sydney Local Health District
Colorectal Sessile Serrated Adenomas/Polyps
The Real-time Optical Diagnosis Value of Optical Enhancement Endoscopy in Colorectal Sessile Serrated Adenomas/Polyps
When a polyp is found, we begin to wash it and observe it with OE mode 1.Then,the endoscopist gives a real-time optical diagnosis and the future surveillance interval.Finally,the polyp will be resected for the biopsy.
- Trial name
- NCT03238573
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University