Clinical trials: Severe ARDS
ARDS, Human, Sepsis, Severe
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective randomized study.
- Trial name
- NCT04508296
- Testing
- Goal directed de-escalation therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Northern State Medical University
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
Therapeutic plasma exchange (TPE) has been proposed as a rescue therapy in critically ill COVID-19 patients. The aim of this study is to determine whether combining TPE with convalescent plasma (CVP) transfusion early during the…
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04973488
- Testing
- Therapeutic plasma exchange
- Where
- Romania
- Volunteers
- 38 people
- Sponsor
- Novacescu Alexandru
COVID-19 Pneumonia
Efficacy and Safety Study of BDB-001 in Severe COVID-19 With ALI/ARDS
This multi-center, open, randomized study will evaluate the efficacy and safety of BDB-001 injection in severe COVID-19 with severe pneumonia, or acute lung injury/acute respiratory distress syndrome.
- Trial name
- NCT04449588
- Testing
- BDB-001 Injection, Conventional treatment
- Where
- 12 sites in Bangladesh, China and 3 more
- Volunteers
- 369 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Acute Respiratory Distress Syndrome (ARDS), Intensive Care Units (ICUs)
Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol
Despite best supportive care, mortality of the Acute Respiratory Distress Syndrom (ARDS) remains high. In the absence of specific treatments, providing safe and efficient mechanical ventilation (MV) is key to survival.
- Trial name
- PEPER (NCT06849570)
- Testing
- Minimal distension, Maximal Recruitment, Prone position + early NMBAs
- Where
- 29 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infant, Newborn, Hypertension, Pulmonary
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns
This prospective, randomized controlled trial tested whether initiating iNO therapy earlier would reduce death and reduce the use of extracorporeal membrane oxygenation (ECMO) -- temporary lung bypass -- therapy compared with the…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- Early iNO (NCT00005773)
- Testing
- Inhaled Nitric Oxide, Standard iNO therapy
- Where
- 18 sites in United States
- Volunteers
- 302 people
- Sponsor
- NICHD Neonatal Research Network
Covid19, Respiratory Failure
Nebulised Heparin in Patients With Severe COVID-19
The Can nebulised HepArin Reduce morTality and time to Extubation in Patients with COVID-19 Requiring mechanical ventilation Meta-Trial (CHARTER-MT) is a prospective collaborative individual patient data analysis of randomised…
- Trial name
- CHARTER-MT (NCT04545541)
- Testing
- Nebulised unfractionated heparin (UFH)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Australian National University
COVID, ARDS
Open-label Multicenter Study to Evaluate the Efficacy of PLX-PAD for the Treatment of COVID-19
This clinical trial will examine if a new treatment of Mesenchymal-like Adherent stromal Cells (called PLX-PAD) can help patients intubated and mechanically ventilated due to COVID-19 to recover more quickly with less…
- Trial name
- NCT04614025
- Testing
- PLX-PAD
- Where
- 9 sites in Germany, Israel
- Volunteers
- 23 people
- Sponsor
- Pluristem Ltd.
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients requiring inpatient hospital admission randomized 1:1 to daily Losartan or placebo for 7 days or hospital discharge.
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04312009
- Testing
- Losartan
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Minnesota
Any Condition Underlying Critical Illness
SWedish Intensive Care Biobank
The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden.
- Trial name
- SWIC-B (NCT07582601)
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
COVID, Severe Acute Respiratory Syndrome
LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)
To evaluate the proportion of subjects alive and free of respiratory failure (e.g. need for non-invasive or invasive mechanical ventilation, high flow oxygen, or ECMO) and free of the need for continued renal replacement therapy…
- Conditions
- COVID, Severe Acute Respiratory Syndrome, Sars-CoV2, Acute Kidney Injury
- Trial name
- NCT04402957
- Testing
- LSALT peptide
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 61 people
- Sponsor
- Arch Biopartners Inc.
Respiratory Distress Syndrome, Adult
A Clinical Trial to Evaluate the Safety of agenT-797 in COVID-19 Participants With ARDS
A Phase 1 study of agenT-797 to treat moderate to severe acute respiratory syndrome in Coronavirus disease 2019 (COVID-19) participants.
- Trial name
- NCT04582201
- Testing
- agenT-797
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- MiNK Therapeutics
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Not Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients randomized 1:1 to daily losartan or placebo for 10 days or treatment failure (hospital admission).
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04311177
- Testing
- Losartan
- Where
- 4 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Minnesota
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Effect of Transpulmonary MP on Prognosis of Patients With Severe ARDS Treated With VV-ECMO
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a salvage treatment for severe acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation, Mechanical Power, Transpulmonary Mechanical Power
- Trial name
- NCT06062212
- Testing
- Transpulmonary pressure
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Respiratory Distress Syndrome
Full-Course ECMO Strategy for Moderate-to-Severe ARDS
China faces major challenges in the ECMO management of patients with moderate-to-severe ARDS, including substantial heterogeneity in clinical practice, low weaning success rates, and high complication rates.
- Trial name
- NCT07726953
- Testing
- Full-Course ECMO Management Pathway, Usual Care
- Where
- 39 sites in China
- Volunteers
- 500 people
- Sponsor
- Southeast University, China
Hypoxic Pulmonary Vasoconstriction, Hypoxemia
Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2
Summary Currently, the COVID-19 pandemic has overtaken health systems worldwide, exceeding the capacity of intensive care units.
- Conditions
- Hypoxic Pulmonary Vasoconstriction, Hypoxemia, Acute Respiratory Distress Syndrome, SARS-CoV-2 Acute Respiratory Disease
- Trial name
- COVID-19 (NCT04998253)
- Testing
- Effects in oxygenation and hypoxic pulmonary vasoconstriction
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Traumatic Brain Injury, Acute Respiratory Failure
Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain Injury
Despite almost universal usage of supplemental oxygen therapy in patients presenting in the emergency department with traumatic brain injury (TBI), optimal oxygen levels are unclear.
- Conditions
- Traumatic Brain Injury, Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Acute Brain Injury
- Trial name
- INACHOS (NCT05464277)
- Testing
- Oxygen
- Where
- 2 sites in Greece
- Volunteers
- 1 people
- Sponsor
- Evangelismos Hospital
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Surfactant Dysfunction
Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial
The main objective is to determine the short-term effect of prone positioning in infants with infection-associated severe acute respiratory distress syndrome.
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Surfactant Dysfunction, Infant
- Trial name
- NCT05002478
- Testing
- Prone positioning
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
COVID, ARDS
Double-Blind, Multicenter, Study to Evaluate the Efficacy of PLX PAD for the Treatment of COVID-19
This clinical trial will examine if a new treatment of Mesenchymal-like Adherent stromal Cells (called PLX-PAD) can help patients intubated and mechanically ventilated due to COVID-19 to recover more quickly with less…
- Trial name
- NCT04389450
- Testing
- PLX-PAD
- Where
- 13 sites in United States
- Volunteers
- 66 people
- Sponsor
- Pluristem Ltd.
Emphysema, Acute Respiratory Distress Syndrome
Use of the Hattler Respiratory Assist Catheter in Severe Respiratory Failure
A new artificial lung device has been developed that potentially provides added support to mechanical ventilation for severely damaged lungs.
- Conditions
- Emphysema, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT00288964
- Testing
- Hattler Respiratory Assist Catheter
- Where
- United Kingdom
- Sponsor
- Alung Technologies
Pneumonia
A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure
This clinical trial will evaluate the efficacy and safety of a single intravenous dose of agenT-797 administered in addition to standard of care (SOC), compared with placebo plus SOC, in reducing short-term mortality in adult…
- Trial name
- NCT07615010
- Testing
- agenT-797, Standard of Care (SOC)
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 90 people
- Sponsor
- MiNK Therapeutics