Clinical trials: Severe Acute Pancreatitis
Severe Acute Pancreatitis
High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis
This study is a prospective, randomized, double-blinded, parallel-controlled, multi-central clinical trial for patients with severe acute pancreatitis (SAP).
- Trial name
- NCT06897384
- Testing
- Saline (NaCl 0,9 %), Vitamin C (Ascorbic Acid)
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Ruijin Hospital
Bedside Placement of Nasal Jejunal Tube
A Trial of Bedside Placement of Nasal Jejunal Tube Confirmed by Ultrasound Compared to Placement by Endoscope in Patients With SAP
The investigators assessed the utility of ultrasonography in confirming the position of nasal jejunal tube after bedside placement when compared with endoscopic placement in patients with severe acute pancreatitis.
- Trial name
- SAP (NCT02456155)
- Testing
- placing nasal jejunal tube with ultrasound, placing nasal jejunal tube endoscopically
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li Gang
Pancreatitis, Acute Necrotizing
Effect of Traditional Chinese Medicine on GI Function Recovery and Nutrition Support in SAP
With multicenter randomized control clinical evaluation investigations, the effect of traditional Chinese medicine on gastrointestinal function recovery and nutrition support in early stage of severe acute pancreatitis (SAP) was…
- Trial name
- NCT00508729
- Testing
- Qingyi granules
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Tianjin Nankai Hospital
Pancreatitis
Ulinastatin in Severe Acute Pancreatitis
This study aims to evaluate the effect of ulinastatin in the treatment and prevention of organ failure in severe acute pancreatitis.
- Trial name
- NCT01132521
- Testing
- ulinastatin
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Techpool Bio-Pharma Co., Ltd.
Severe Acute Pancreatitis Patients
Early Rehabilitation for Severe Acute Pancreatitis (ERN-SAP)
This prospective, randomized controlled trial investigates the efficacy of a structured early rehabilitation nursing (ERN) program compared to usual care in patients with severe acute pancreatitis (SAP).
- Trial name
- NCT07109921
- Testing
- Structured Early Rehabilitation Nursing Program, Usual Care
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University
Pancreatitis
Management of Pancreatitis: the Role of Supportive and Drainage Treatment
This study aims to investigate the natural clinical course, diagnostic possibilities and treatment modalities in moderately severe (MSAP) and severe acute pancreatitis (SAP).
- Trial name
- NCT02648815
- Testing
- Percutaneous catheter drainage, Abdominal paracentesis evacuation
- Volunteers
- 100 people
- Sponsor
- University Clinical Center Tuzla
Acute Pancreatitis
Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis
The purpose of this study is to determine the effect and safety of early high-volume continuous veno-venous hemofiltration for patients with severe acute pancreatitis.
- Trial name
- EHVCVVHSAP (NCT01595672)
- Testing
- AN69 hemofilter, conventional treatments
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Air Force Military Medical University, China
Necrotizing Pancreatitis
ABTHERA ADVANCE™ Use Without Wittman Patch
The objective of this study is to evaluate the use of the ABTHERA ADVANCE for patients requiring open abdomen due to necrotizing pancreatitis.
- Trial name
- NCT04986943
- Testing
- Using ABTHERA Advance without a Wittmann Patch
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Acute Pancreatitis
Efficacy of Enteral Glutamine Supplementation in Patients With Predicted Severe Acute Pancreatitis- A Double-Blinded Randomized Controlled Trial
Acute pancreatitis (AP) is a potentially serious illness characterized by inflammation of the pancreas with variable involvement of peri-pancreatic tissues and/ or remote organ systems.
- Trial name
- NCT01503320
- Testing
- Enteral glutamine
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Pancreatitis, Complication of Ventilation Therapy
Effect of Early Mechanical Ventilation to Severe Acute Pancreatitis
Acute lung injury (ALI) and acute respiratory distress syndrome(ARDS) represent the most common and earliest organ dysfunction in acute pancreatitis, presenting as dyspnea and intractable hypoxemia, with secondary bilateral…
- Trial name
- NCT01992224
- Testing
- early mechanical Ventilation, Conventional Mechanical Ventilation
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Ruijin Hospital
Pancreatitis, Multiple Organ Failure
Albumindialysis in Acute Pancreatitis
The incidence of acute pancreatitis has been doubled during last three decades in Finland. Alcohol is the main cause of acute pancreatitis in Finland accounting for 70 % of cases.
- Trial name
- pancreatitis (NCT00483912)
- Testing
- Molecular adsorbent recirculating system
- Where
- Finland
- Sponsor
- Tampere University
Post-ERCP Acute Pancreatitis
Prediction of PEP Based on the Appearance of the Major Duodenal Papilla
This observational, prospective study aims at evaluating how the occurrence of post-Endoscopic Retrograde CholangioPancreatography (ERCP) acute pancreatitis (PEP) could be influenced by difficult biliary cannulation that might be…
- Trial name
- PredERCP (NCT05800626)
- Testing
- Endoscopic Retrograde Cholangio-Pancreatography (ERCP)
- Where
- 2 sites in Italy
- Volunteers
- 1,740 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pancreatitis, Acute Necrotizing
The Study of Laparoscopic-assisted Percutaneous Catheter-directed Drainage to Treat Early Severe Acute Pancreatitis
The purpose of this study is to analyze the effect of laparoscopic-assisted percutaneous catheter drainage of early SAP(severe acute pancreatitis).We are going to select 60 cases SAP patients from April 2014 to April 2015 who…
- Trial name
- NCT02133014
- Testing
- laparoscopic-assisted percutaneous catheter drainage, 0.5% 5-fluorouracil normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Acute Necrotizing Pancreatitis
Early Enteral Nutrition for Severe Acute Pancreatitis
There is increasing evidence that indicates early enteral nutrition may be associated with improved outcome in acute pancreatitis patients.
- Trial name
- NCT00995098
- Testing
- early enteral nutrition, Parenteral nutrition
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sichuan Academy of Medical Sciences
Acute Pancreatitis (AP), Diabetes Mellitus
Endocrine and Exocrine Secretory Function Alterations After Moderately Severe and Severe Acute Pancreatitis
The goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (PPDM-A). The main questions it aims to answer are: 1.
- Trial name
- NCT06590935
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Changzheng Hospital
Severe Acute Pancreatitis
Epidural Analgesia for Pancreatitis (Epipan Study)
Acute pancreatitis (AP) is a common disease whose incidence in the US reaches 35 per 100,000 population annually. Its main causes in adults are gallstone migration into the common bile duct and alcohol abuse.
- Trial name
- EPIPAN (NCT02126332)
- Testing
- ropivacaine and sufentanil, acetaminophen, nefopam, tramadol, opidoids
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypertriglyceridemia
Efficacy and Safety of Evinacumab in Adult Patients With Severe Hypertriglyceridemia for the Prevention of Recurrent Acute Pancreatitis
The primary objective of the study is to determine the proportion of patients with elevated triglycerides (TG), without familial chylomicronemia syndrome (FCS) due to loss of function (LoF) mutations in lipoprotein lipase (LPL)…
- Trial name
- NCT04863014
- Testing
- evinacumab
- Where
- 39 sites in United States, Canada and 2 more
- Volunteers
- 21 people
- Sponsor
- Regeneron Pharmaceuticals
Pancreatitis, Acute
Safety and Tolerability of Pirfenidone in Acute Pancreatitis
The goal of the current pilot clinical trial is to evaluate the safety and tolerability of pirfenidone in patients with predicted moderately severe and severe acute pancreatitis.
- Trial name
- NCT05350371
- Testing
- Pirfenidone Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Acute Pancreatitis, Intestinal Bacteria Flora Disturbance
Fecal Microbiota Transplantation (FMT) for Severe Acute Pancreatitis(SAP)
Severe acute pancreatitis is an acute and rapid progress of the digestive system disease.Most patients with severe pancreatitis associated with intestinal mucosal barrier dysfunction.Intestinal microflora,an important part of the…
- Conditions
- Acute Pancreatitis, Intestinal Bacteria Flora Disturbance, Intestinal Dysfunction, Fecal Microbiota Transplantation
- Trial name
- NCT03015467
- Testing
- Fecal Microbiota Transplantation, normal saline
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Pancreatitis, Acute, SIRS
Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal
Severe acute pancreatitis (SAP) has a mortality of up to 42%. The outcome of SAP is related to the development of SIRS and consecutive organ failures.
- Trial name
- PACIFIC (NCT03082469)
- Testing
- CytoSorb
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich