Clinical trials: Severe Asthma Exacerbation
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
Status Asthmaticus, Asthma (Diagnosis)
IV DEXAMETHASONE VS. METHYLPREDNISOLONE IN CHILDREN WITH SEVERE ASTHMA EXACERBATION
The study aims to determine whether a two-day intravenous course of dexamethasone is non-inferior to a conventional five-day intravenous course of methylprednisolone in children presenting with severe asthma exacerbations.
- Conditions
- Status Asthmaticus, Asthma (Diagnosis), Asthma Exacerbations
- Trial name
- IV:INTRAVENOUS (NCT07731217)
- Testing
- Intravenous Dexamethasone, Intravenous Methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Istanbul Medeniyet University
Severe Asthma
Severe Asthma Exacerbations and Mepolizumab Treatment
This is a hypothesis-generating project to investigate a) infective etiology and b) inflammatory profile of the exacerbations of asthma in severe asthmatic patients treated with the humanized monoclonal antibody against…
- Trial name
- ESAM-BIO (NCT04914078)
- Testing
- Mepolizumab 100 MG
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Università degli Studi di Ferrara
Eosinophilic Asthma
Phase III Long-Term Extension Study With Dexpramipexole
The goal of this clinical trial] is to evaluate the long term safety of dexpramipexole treatment in participants with severe asthma, aged ≥18 years, on Global Initiative for Asthma (GINA) 2021 [GINA, 2021] Step 4 or 5 therapy and…
- Trial name
- EXHALE-5 (NCT06388889)
- Testing
- Dexpramipexole Dihydrochloride
- Where
- 103 sites in United States, Argentina and 13 more
- Volunteers
- 509 people
- Sponsor
- Areteia Therapeutics
Acute Asthma Exacerbation
Acute Montelukast in Asthma
Patients presenting to hospital with an acute asthma exacerbation severe enough to require admission would receive full standard treatment according to British Thoracic Society guidelines in addition they would be offered the…
- Trial name
- AcMk (NCT01011452)
- Testing
- Montelukast
- Where
- United Kingdom
- Volunteers
- 87 people
- Sponsor
- University of East Anglia
Eosinophilic Asthma, Asthma; Eosinophilic
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.
This study will assess the efficacy and safety of dexpramipexole as an adjunctive oral therapy in participants with inadequately controlled asthma with an eosinophilic phenotype and a history of asthma exacerbations.
- Conditions
- Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
- Trial name
- EXHALE-2 (NCT05763121)
- Testing
- Dexpramipexole Dihydrochloride
- Where
- 401 sites in United States, Argentina and 18 more
- Volunteers
- 1,061 people
- Sponsor
- Areteia Therapeutics
Childhood Asthma With Status Asthmaticus
Status Asthmaticus on the PICU; Intravenous Salbutamol
Although IV salbutamol is frequently used in children in a wide range, pharmacodynamic data are scarce. To date, there is an insufficient evidence base to guide initial and subsequent dosing recommendation for its IV use in…
- Trial name
- STATIC IV (NCT03493503)
- Testing
- Salbutamol, Sodium Chloride 0.9%
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
Eosinophilic Asthma, Asthma; Eosinophilic
A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma (EXHALE-3)
The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.
- Conditions
- Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
- Trial name
- EXHALE-3 (NCT05813288)
- Testing
- Dexpramipexole Dihydrochloride
- Where
- 282 sites in United States, Argentina and 24 more
- Volunteers
- 654 people
- Sponsor
- Areteia Therapeutics
Asthma
Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations
The purpose of this trial is to compare the efficacy of 4 to 5 months of three treatments - omalizumab, corticosteroid therapy boost, and placebo - in reducing fall exacerbations in inner-city children and adolescents with…
- Trial name
- PROSE (NCT01430403)
- Testing
- Omalizumab, Inhaled Corticosteroid Boost Therapy (ICS)
- Where
- 8 sites in United States
- Volunteers
- 478 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
A Study in Asthma Patients to Evaluate Efficacy, Safety and Tolerability of 14 Days Once Daily Inhaled Interferon Beta-1a After the Onset of Symptoms of an Upper Respiratory Tract Infection
A study to investigate if inhaled Interferon beta-1a is safe and tolerated, and can prevent or reduce the severity of asthma attacks when administered to asthma patients at the onset of symptoms of common cold or influenza
- Trial name
- INEXAS (NCT02491684)
- Testing
- Interferon beta-1a Nebuliser solution 48 μg/mL
- Where
- 35 sites in Argentina, Australia and 5 more
- Volunteers
- 121 people
- Sponsor
- AstraZeneca
Asthma
Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Project Aim: To determine if intramuscular epinephrine is an effective adjunct to inhaled bronchodilators (β2 agonists) for children with severe asthma exacerbation.
- Trial name
- NCT01705964
- Testing
- IM epinephrine 1:1000, No intervention
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Louisville
Asthma; Status, Asthma in Children
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations
Objective: To determine the extent to which high-dose (30mg) oral montelukast, added to standard treatment in children with moderate and severe acute exacerbations improves outcomes.
- Conditions
- Asthma; Status, Asthma in Children, Asthma Acute, Asthma Attack
- Trial name
- NCT03277170
- Testing
- Montelukast Oral Granules
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Acute Severe Asthma
Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Trial name
- NCT02112305
- Testing
- isotonic magnesium sulphate, 50% magnesium sulphate
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Asthma
Efficacy and Safety Study of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
This study aimed to determine the efficacy and safety of QAW039 150 mg and QAW039 450 mg, compared with placebo, when added to GINA (Global Initiative for Asthma) steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2016)…
- Trial name
- NCT02555683
- Testing
- QAW039
- Where
- 234 sites in United States, Argentina and 25 more
- Volunteers
- 894 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma)
This study will determine whether vitamin D3 prevents severe asthma attacks in children who have a serum vitamin D (25(OH)D) level <30 ng/ml and who are being treated with inhaled corticosteroids for asthma.
- Trial name
- NCT02687815
- Testing
- vitamin D3 4000 IU
- Where
- 7 sites in United States
- Volunteers
- 192 people
- Sponsor
- Juan Celedon, MD
Asthma
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week…
- Trial name
- NCT04129931
- Testing
- MCT, Clazakizumab, Broncho-Vaxom
- Where
- 29 sites in United States
- Volunteers
- 950 people
- Sponsor
- University of North Carolina, Chapel Hill
Asthma, Chronic Inflammatory Diseases
Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics
Asthma is a chronic inflammatory disease, affecting up to 10 % of the general population in developed countries. Corticosteroids are necessary to control symptoms, but induce adverse events sometimes intolerable.
- Trial name
- EXPRESA (NCT00721097)
- Testing
- spirometry, and blood taken
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Asthma Exacerbations, Severe Asthma
Bronchial Thermoplasty for Adults With Severe Asthma in the Biologic Era
Rationale: For patients with severe asthma that remain uncontrolled with exacerbations despite biologics or patients who are not eligible for biologics, there is no reimbursed treatment other than pulmonary rehabilitation in the…
- Conditions
- Asthma Exacerbations, Severe Asthma, Bronchial Thermoplasty
- Trial name
- BOOSTER (NCT07292805)
- Testing
- Bronchial thermoplasty
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Asthma, COPD
Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease
The aim of the project is to study pathogenetic mechanisms in severe asthma and compare those mechanisms in chronic obstructive pulmonary disease (COPD) in order to test the hypothesis that severe asthma and COPD develop into…
- Trial name
- BIOAIR (NCT00555607)
- Testing
- prednisolone
- Where
- Sweden
- Volunteers
- 233 people
- Sponsor
- Karolinska Institutet
Asthma
Laminar Airflow in Severe Asthma for Exacerbation Reduction
To ascertain whether home-based nocturnal TLA usage over a 12 month period can reduce exacerbations and improve asthma control and quality of life as compared to placebo, whilst being cost-effective and acceptable to adults with…
- Trial name
- LASER (NCT03058497)
- Testing
- Temperature-Controlled Laminar Airflow Device (Airsonett®)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust