Clinical trials: Severe Brain Injury
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Traumatic Brain Injury
In-Field Detection of Intracranial Pressure
This is a research study to develop a noninvasive test using ultrasound to determine when urgent, life-saving treatment is needed for those with severe traumatic brain injuries.
- Trial name
- NCT04515212
- Testing
- Optic Nerve Ultrasounds
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Duke University
Sepsis, Trauma Injury
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems.
- Trial name
- NCT05357170
- Testing
- Human feces collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Craniocerebral Trauma, Traumatic Brain Injury
Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury.
The aim of this study is to determine whether passive gait training increases arousal, demonstrated as changes in EEG (electroencephalogram) activity.
- Conditions
- Craniocerebral Trauma, Traumatic Brain Injury, "Rehabilitation"
- Trial name
- NCT00430703
- Testing
- body weight support treadmill training
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Severe Traumatic Brain Injury
The Systemic Nature of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a devastating condition with no targeted therapies available to prevent secondary injury.
- Trial name
- MANTRA (NCT07679126)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Corewell Health West
Stress Reaction, Stress Related Disorder
Research on the Effects of Combined Neurostimulation Protocols on Stress
The study examines the effects of the combined use of two different non-invasive brain stimulation (NIBS) techniques targeting the DLPFC on stress reactivity and recovery.
- Conditions
- Stress Reaction, Stress Related Disorder, Major Depressive Disorder
- Trial name
- NCT03722095
- Testing
- active tDCS, iTBS
- Where
- Belgium
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Ghent
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Concussion, Mild, Concussion, Intermediate
Biomarkers in Concussion
This will be an observational study measuring serum Neurofilament Light Chain concentrations and associated symptoms, with a control branch, and a post-concussion branch.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NCT05943561
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Disorders of Consciousness, Acquired Brain Injury
Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Assessment of consciousness and attention in individuals with severe Acquired Brain Injury (sABI) is crucial for planning rehabilitation, but it is often hindered by coexisting sensory-motor and/or cognitive-behavioural…
- Trial name
- SEE-ABI (NCT06464549)
- Testing
- EEG-EOG recording at rest and during an auditory oddball paradigm
- Where
- 2 sites in Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Severe Traumatic Brain Injury, Subarachnoid Hemorrhage
Cortical Excitability in Patients With Severe Brain Injury
The aim of the study is to evaluate the cortical excitability in the severe brain injured patients. We hypothesize that: 1. There is a continuous decrease in intracortical inhibition from healthy subjects to awake patients with…
- Conditions
- Severe Traumatic Brain Injury, Subarachnoid Hemorrhage, Anoxic Brain Injury
- Trial name
- NCT00788723
- Testing
- Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Concussion, Mild, Concussion, Intermediate
Assessment of the Effects of Concussion on Adolescent Rugby Union Players
200 adolescent rugby players (aged 15-19) from the Senior Cup Teams of 5 Rugby Playing schools (Members of Irish Schools Rugby) will be invited to enroll for inclusion in the study.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NCT03624634
- Where
- Ireland
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Sports Surgery Clinic, Santry, Dublin
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
- Trial name
- NCT05671874
- Testing
- Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Mental Health, Neurodevelopment
Investigating the Impacts of Early Life Experience on the Brain & Behaviour
The aim of this study is to learn more about how early life experience influences the brain, behaviour, and the immune system later in life.
- Conditions
- Mental Health, Neurodevelopment, ADHD, Autism
- Trial name
- NCT06823492
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cognitive Dysfunction, Burns
PRIME: Cognitive Outcome Following Major Burns
PRIME aims to demonstrate through neurocognitive assessment that BICU patients will have a degree of neurocognitive dysfunction following a major burn, that this neurocognitive dysfunction is due to an underlying…
- Conditions
- Cognitive Dysfunction, Burns, Inflammation, Brain, Quality of Life
- Trial name
- PRIME (NCT03242395)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust