Clinical trials: Severe Brain Injury
Disorder of Consciousness, Traumatic Brain Injury
Changes in Glutamatergic Neurotransmission of Severe TBI Patients
Studies in patients with disorders of consciousness (DOC) after severe brain injury implicate dysfunction of the anterior forebrain mesocircuit dysfunction a key underlying mechanism.
- Trial name
- NCT04244058
- Testing
- Amantadine + L-DOPA, NMDA blocker
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Swallowing Disorders, Dysphagia
Development and Validation of the SWADOC Tool
Background: After a period of coma, patients with severe brain injury may present disorders of consciousness (DOC). A wide proportion of these patients also suffer from severe dysphagia.
- Conditions
- Swallowing Disorders, Dysphagia, Disorders of Consciousness, Assessment Tool
- Trial name
- NCT04706689
- Testing
- SWADOC tool, FOTT-SAS
- Where
- 8 sites in Belgium, France
- Volunteers
- 104 people
- Sponsor
- University of Liege
Children Brain Injury
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Intracranial hypertension (ICH) is a common and serious complication in children admitted to pediatric intensive care units. It is primarily caused by traumatic brain injury but can also result from brain malformations, brain…
- Trial name
- OSMOPUPILLO (NCT06642896)
- Testing
- pupillometer
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Traumatic Brain Injury, Ischemic Stroke
Shared Decision Making to Improve Goals-of-Care Decisions for Families of Severe Acute Brain Injury Patients
Severe acute brain injury (SABI), including large artery acute ischemic stroke, intracerebral hemorrhage, and severe traumatic brain injury continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT03833375
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Massachusetts, Worcester
Brain Injuries
Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring
This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients.
- Trial name
- CPM-Brain (NCT07198490)
- Volunteers
- 50 people
- Sponsor
- Xingui Dai
Brain Injury, Craniocerebral Trauma
PariS-TBI Study : Paris Severe Traumatic Brain Injury Study
The primary objective of the protocol is to study the long-term outcome of a large group of traumatic brain injury patients. This outcome is to be described in terms of activity, participation, quality of life, SOCIO-professional…
- Conditions
- Brain Injury, Craniocerebral Trauma, Trauma Nervous System
- Trial name
- PariS-TBI (NCT01437683)
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Injury Traumatic Severe
Severe Head Injury Brain Analysis
Safety and feasibility study investigating brain biopsy in severe head injury. When a patient undergoes craniotomy or ICP bolt insertion for trauma, a biopsy of brain tissue is taken.
- Trial name
- SHIBA (NCT05206760)
- Testing
- Brain biopsy
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Queen Mary University of London
Brain Injury Traumatic Severe, Disorder of Consciousness
Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness
This study first aims to validate the feasibility of a multimodal 5-day 20-minute tACS protocol in subacute brain-injured patients with a disorder of consciousness during their ICU stay, and conduct a clinical pilot study…
- Conditions
- Brain Injury Traumatic Severe, Disorder of Consciousness, Brain Injuries
- Trial name
- NCT05833568
- Testing
- Active Transcranial alternative current stimulation
- Volunteers
- 138 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Patients in Minimally Conscious State After a Severe Brain Injury
tDCS on Precuneus in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02702362
- Testing
- transcranial direct current stimulation
- Volunteers
- 33 people
- Sponsor
- Hangzhou Normal University
Severe Brain Injury
Evaluation of Risk Factors Regarding Extubation Failure in Severe Brain Injured Patients.
Severe brain-injured patients require prolonged mechanical ventilation. Weaning these patients from mechanical ventilation is challenging.
- Trial name
- NCT02426242
- Testing
- Collection of medical data from ICU patients
- Where
- 3 sites in France
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Major Depressive Disorder, Traumatic Brain Injury
Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury
Cognitive behavioral therapy for major depressive disorder (MDD) was adapted for individuals with moderate to severe traumatic brain injury (TBI) (CBT-TBI). A structured, treatment manual was developed.
- Trial name
- NCT03307070
- Testing
- Cognitive Behavioral Therapy for individuals with TBI, Waitlist Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Intracranial Pressure, Brain Injuries, Traumatic
Correlation Patterns of Brain Temperature-Pressure in Acute Brain Injury
The goal of this prospective, multicenter, observational, cohort trail is to explore the pattern of brain temperature-brain pressure association in acute brain injury and to clarify its predictive value for prognosis and…
- Conditions
- Intracranial Pressure, Brain Injuries, Traumatic, Subarachnoid Hemorrhage, Cerebral Hemorrhage
- Trial name
- MERCURY (NCT06101537)
- Testing
- Brain temperature-pressure monitoring
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Tiantan Hospital
Irreversible Loss of Brain Function (ILBF)
Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death).
- Trial name
- DETECT-IVE (NCT06293170)
- Testing
- DETECT, Conventional care
- Where
- Germany
- Volunteers
- 4,800 people
- Sponsor
- Technische Universität Dresden
Ventilator-associated Pneumonia, Traumatic Brain Injury
Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain Injury
This randomized controlled trial will compare closed versus open endotracheal suctioning techniques for preventing ventilator-associated pneumonia (VAP) in adults with severe traumatic brain injury (TBI) who need mechanical…
- Trial name
- NCT07883083
- Testing
- Closed endotracheal suction system, Open endotracheal suction
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University
Cerebral Palsy, Spastic
Application of 3D Scanner to Measure Physical Size in Patients With Severe Cerebral Palsy
The aim of this study is to improve the manufacturing techniques of hip brace in preventing progressive hip displacement in patients with severe cerebral palsy, through the measurement of patient's physical size using a 3D…
- Trial name
- NCT05388422
- Testing
- Application of 3D scanner to measure physical size in patients with severe cerebral palsy
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul National University Hospital
Severe Traumatic Brain Injury, Trauma
Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation.
Severe brain injury (SBI) is one of the world's leading causes of death and disability in young adults, but its peripheral vascular consequences in humans are poorly understood.
- Trial name
- MicroTC (NCT04597879)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Subarachnoid Hemorrhage, Traumatic
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
The goal of this prospective multi-center observational study is to learn about the osmotic therapy in severe subarachnoid hemorrhage (SAH).
- Trial name
- OSMO-SAH (NCT05858060)
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xuanwu Hospital, Beijing
Concussion, Mild, Concussion, Intermediate
Biomarkers in Concussion
This will be an observational study measuring serum Neurofilament Light Chain concentrations and associated symptoms, with a control branch, and a post-concussion branch.
- Conditions
- Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- NCT05943561
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Brain Injury Traumatic Severe, Subarachnoid Hemorrhage
Mobilising Patients With Severe Brain Injury in Intensive Care
Introduction Patients with severe brain injury are often restricted to bed rest during the early period of brain injury which may lead to unwanted secondary complications.
- Conditions
- Brain Injury Traumatic Severe, Subarachnoid Hemorrhage, Intracranial Hematoma
- Trial name
- MAWERIC (NCT05038930)
- Testing
- Mobilisation using the Sara Combilizer
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acquired Brain Injury, Dysphagia
Local Vibration in Patients with Severe Acquired Brain Injury
Severe Acquired Brain Injury (sABI), with a more or less prolonged state of coma, generally causes disruption of the physiological modes of swallowing and feeding and the physiological abilities of communication and phonation.
- Trial name
- NCT05729165
- Testing
- Novafon® Pro, Conventional Therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS