Clinical trials: Severe Brain Injury
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Brain Injury, Tracheostomy
Efficacy of an Early Rehabilitation on Decannulation Time of Patients With Severe Acquired Brain Injury
All the patients hospitalized in the neuro-rehabilitation after a severe acquired brain injury carrying a tracheal cannula will be retrospectively analyzed.
- Conditions
- Brain Injury, Tracheostomy, Neurological Rehabilitation
- Trial name
- NCT02990871
- Testing
- early neurological rehabilitation, no-early neurological rehabilitation
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Acquired Brain Injury
Exploring the Use of the Cognitive Orientation to Daily Occupational Performance Approach (CO-OP) With Children, Teenagers and Young Adults With Executive Functions Deficits Following Severe Acquired Brain Injury
Acquired brain injury (ABI) in childhood are the cause of disabling motor, cognitive and behavioural disorders, with severe consequences on the later development of autonomy and learning, with long-term repercussions on…
- Trial name
- REFECO-OP (NCT04560777)
- Testing
- CO-OP intervention
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Cerebral Palsy
Eye-tracking Working Memory Training in Children and Youth With Severe Cerebral Palsy
People with severe cerebral palsy (CP) who are nonverbal and unable to control conventional computer interfaces due to the severe limitations in hand control benefit from eye-tracking technology as access method to Augmentative…
- Trial name
- NCT06918379
- Testing
- Cogmed Working Memory Training (CWMT)
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- KU Leuven
Cerebral Palsy, Kinesiology Taping
Short-term Effects Kinesiology Tape on Sitting Postural Control in Moderate and Severe Cerebral Palsy
To analyze the short-term effect of kinesiology taping on sitting postural control in moderate and severe cerebral palsy
- Conditions
- Cerebral Palsy, Kinesiology Taping, Postural Control
- Trial name
- KT-SIT_CP (NCT04991623)
- Testing
- Kinesiology taping, Conventional physiotherapy
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- University of Castilla-La Mancha
Energy Metabolism and Muscle Mass Changes in Patients With Severe Brain Injury
Observational Study on Energy Expenditure and Protein Metabolism Changes in Patients With Severe Brain Injury.
Evaluation of early energy metabolism and muscle mass changes in patients with severe brain injury, the impact of nutritional therapy on metabolism and muscle mass, and their relationship with patient prognosis, to provide…
- Trial name
- NCT06577402
- Testing
- nutritional support
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Southeast University, China
Brain Injuries
Use of Standing Frame and "Innowalk Pro" in Patients With TBI
This study will explore physical and physiological responses to mobilization of patients with acquired brain injuries in subacute phase using a classic standing frame and a standing device with simultaneous passive movement of…
- Trial name
- NCT04452019
- Testing
- Use of standard standing frame, Use of a new device; Innowalk Pro
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Vegetative State, Minimally Conscious State
Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- NCT02626403
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University of Liege
Brain Injuries, Traumatic
Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury
This study is a prospective single-centre randomized trial to compare the effect of tranexamic acid versus placebo in the pre-hospital management of patients with moderate and severe traumatic brain injury.
- Trial name
- NCT02645552
- Testing
- Tranexamic Acid, Sodium chloride
- Where
- China
- Volunteers
- 400 people
- Sponsor
- RenJi Hospital
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Brain Injury Traumatic Severe, Serum Concentrations
Electrolyte Imbalance in Surgical and Non-Surgical Geriatric Brain Injury Patients
Investigators invite you to the research titled "Evaluation of Serum Electrolyte Imbalance in Geriatric Patients Undergoing Brain Surgery: A Prospective Randomized Observational Study" conducted by Specialist Nurse Tülin KURT…
- Conditions
- Brain Injury Traumatic Severe, Serum Concentrations, Nursing, Geriatric Patients
- Trial name
- NCT07809880
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Zonguldak Bulent Ecevit University
Acquired Brain Injury, Comparative Effectiveness Research
Efficacy of EFA in Acquired Brain Injury
Acquired brain injury (ABI) is one of the biggest cause of death and disability in the world. Patients with ABI often have difficulties with swallow and breath.
- Conditions
- Acquired Brain Injury, Comparative Effectiveness Research, Lung Diseases, Obstructive
- Trial name
- NCT05993364
- Testing
- Free Aspire with Expiratory Flow Accelerator (EFA) technology, In-Exufflator Machine, Traditional respiratory treatment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Traumatic Brain Injuries
Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Severe Traumatic Brain Injury
"Severe traumatic brain injury (TBI) is a serious condition, common in young adults. It leads to sensorimotor and cognitive sequelae that hinder social reintegration.
- Trial name
- TC-Mouv (NCT05094999)
- Testing
- Proprioceptive stimulations
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Vascular Severe Brain Injury
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict.
- Conditions
- Stroke, Vascular Severe Brain Injury, Rehabilitation
- Trial name
- PRISMA (NCT06871800)
- Testing
- blood withdrawal
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Acquired Brain Injury
Virtual Reality vs Traditional Cognitive Training in Patients With Severe Acquired Brain Injury
Considerable evidence exists for using Virtual Reality (VR) for rehabilitation of acquired brain injury (ABI), with a particular focus on stroke.
- Trial name
- VR-sABI (NCT06474871)
- Testing
- Khymeia®-Virtual Reality rehabilitation System (VRRS EVO SYSTEM or COMPACT VRRS ENGINE), Traditional cognitive training (TCT)
- Where
- 5 sites in Italy
- Volunteers
- 28 people
- Sponsor
- Anna Estraneo
Traumatic Brain INjury
IL-1ra Dose-range Study for Moderate-to-severe TBI Patients
Traumatic brain injury (TBI) is a common condition with high degree of morbidity and mortality (Hyder et al., 2007). Current treatment paradigms for TBI focus on mitigating secondary injury and maintaining cerebral physiology…
- Trial name
- IL1ra (NCT02997371)
- Testing
- Anakinra Prefilled Syringe, Isotonic saline
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Adel Helmy
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine