Clinical trials: Severe Brain Trauma
Ventilator Associated Pneumonia, Morality
Endotracheal Tube Cuff Pressure Measurement
The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.
- Conditions
- Ventilator Associated Pneumonia, Morality, Trauma, Brain, Endotracheal Aspiration
- Trial name
- NCT04397952
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Brain Injuries
Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring
This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients.
- Trial name
- CPM-Brain (NCT07198490)
- Volunteers
- 50 people
- Sponsor
- Xingui Dai
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Head Trauma, Intensive Care Neurological Disorder
Anti-secretory Factor as a Treatment for Adults With Severe Traumatic Head Injury
Introduction/Background Brain swelling/brain edema can occur due to many pathologies of the brain, such as infections, ischemia and trauma. The edema can be either primarily intra-cellular or extra-cellular.
- Conditions
- Head Trauma, Intensive Care Neurological Disorder, Edema Brain
- Trial name
- SATSWEDEN (NCT03453749)
- Testing
- Salovum
- Sponsor
- Peter Siesjö
Brain Injuries
Tranexamic Acid for Preventing Progressive Intracranial Haemorrhage in Traumatic Brain Injury
The study's objective is to evaluate the effectiveness and safety of tranexamic acid for adult patients with moderate to severe TBI.With the research question as "Does TXA reduce the incidence of progressive intracranial…
- Trial name
- NCT00755209
- Testing
- tranexamic acid
- Where
- Thailand
- Volunteers
- 238 people
- Sponsor
- Khon Kaen University
Moderate to Severe Traumatic Brain Injury
FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial
The goal of this clinical trial is to learn about treatment with fresh frozen plasma (FFP) in individuals with moderate to severe traumatic brain injury.
- Trial name
- NCT06062888
- Testing
- Fresh Frozen Plasma (FFP)
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Northwestern University
Iatrogenic Withdrawal Symptomes
Iatrogenic Withdrawal Symptoms in Severe Traumatic Brain Injury
Iatrogenic withdrawal symptomes has been associated with prolonged mechanical ventilation and the and the derived symptoms such as fever and agitation has been shown to cause significantly prolonged ICU and hospital length of…
- Trial name
- NCT04320927
- Where
- Denmark
- Volunteers
- 215 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Brain Injuries, Traumatic, Cerebrovascular Circulation
CPPopt Guided Therapy: Assessment of Target Effectiveness
Despite improvements in management, mortality in severe traumatic brain injury (TBI) remains 25% and only 40% of patients survive without major handicap.
- Conditions
- Brain Injuries, Traumatic, Cerebrovascular Circulation, Homeostasis
- Trial name
- COGITATE (NCT02982122)
- Testing
- For both groups, CPP targets will be achieved first by ICP control if this is raised and then by ABP support by titration (up or down) of vasopressors and fluids according to local protocols.
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Critical Illness, Intensive Care Patients
IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients
This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU).
- Conditions
- Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury
- Trial name
- IMMUNOREA (NCT07345169)
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Traumatic Brain Injury, Gait Disorders, Neurologic
Vestibular Rehabilitation and Severe Traumatic Brain Injury
Severe brain injury (sTBI) is one of the most common causes of long-term disability and is considered the most frequent cause of mortality and serious disability in young adults in industrialized countries.
- Trial name
- NCT04415580
- Testing
- Vestibular Rehabilitation (VR), Conventional Neurorehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Traumatic Brain Injury
Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) represents a significant public health risk in the United States leaving many survivors with significant long term cognitive deficits and at risk for neurodegenerative diseases.
- Trial name
- NCT04530032
- Testing
- ketogenic/modified Atkins diet, Standard diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Loma Linda University
Subarachnoid Hemorrhage, Severe Traumatic Brain Injury
Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever
When fever is present in patients with stroke, traumatic brain injury (TBI), or brain hemorrhage, it has been associated with worse outcomes including larger areas of tissue death, increased length of stay, worse degree of coma…
- Trial name
- SNIF (NCT00890604)
- Testing
- Stepwise normothermia protocol, Ibuprofen, Acetominophen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder (PTSD), Depression - Major Depressive Disorder
To Investigate the Change of Brain and Autonomic Function From Different Protocols of Repeated Transcranial Magnetic Stimulation Therapy for Patients With Post-traumatic Stress Disorder Comorbid Major Depressive Disorder
This study aims to investigate the immediate neurophysiological and autonomic effects of two noninvasive brain stimulation protocols-prolonged intermittent theta-burst stimulation (prolonged iTBS) and high-frequency repetitive…
- Trial name
- NCT07327385
- Testing
- Prolonged Intermittent Theta-Burst Stimulation (prolonged iTBS), High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Walking With Overground Robotic Exoskeleton Device to Increase Behavioral Responsiveness in Patients With Disorders of Consciousness (WALK DOC)
The goal of this observational study is to learn whether walking with an overground robotic exoskeleton (ORE) can improve responsiveness and brain activity in adults with disorders of consciousness (DoC) during inpatient…
- Trial name
- WALK DOC (NCT07709559)
- Testing
- Overground Robotic Exoskeleton (ORE)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Spaulding Rehabilitation Hospital
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Brain Injuries, Disorder of Consciousness
Predictors of Better Outcomes After Severe Acquired Brain Injuries
Severe Acquired Brain Injury is defined as a traumatic, post-anoxic, vascular or other brain damage that causes coma for at least 24 hours and leads to permanent disability with sensorial, motor, cognitive or compartmental…
- Trial name
- FP-GCA (NCT04495192)
- Testing
- Genetic analysis of different single nucleotide polymorphisms on ApoE, BDNF and DRD2 genes assessment
- Where
- Italy
- Volunteers
- 520 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder
Trauma-related Major Depressive Disorder (MDD) is frequently associated with poor response to conventional antidepressants, persistent psychological distress, and alterations in gut-brain axis function.
- Trial name
- NCT07703722
- Testing
- Psilocybin, Structured Integrated Reframing Therapy (SIRT), Selective Serotonin Reuptake Inhibitor (SSRI)
- Where
- 3 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Medical University Peshawar
Energy Metabolism and Muscle Mass Changes in Patients With Severe Brain Injury
Observational Study on Energy Expenditure and Protein Metabolism Changes in Patients With Severe Brain Injury.
Evaluation of early energy metabolism and muscle mass changes in patients with severe brain injury, the impact of nutritional therapy on metabolism and muscle mass, and their relationship with patient prognosis, to provide…
- Trial name
- NCT06577402
- Testing
- nutritional support
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Southeast University, China
Traumatic Brain Injury
MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Patients with a diagnosis of moderate to severe traumatic brain injury (TBI) will be enrolled. Subjects will be randomly assigned to receive either MLC901 (Specified Drug Code) or placebo capsules three times per day over 6…
- Trial name
- MLC901 (NCT04487275)
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Ali Amini Harandi