Clinical trials: Severe Burn
Hypercatabolic Status Related to Severe Burn
Study of Tolerability and Efficacy of BVS857 in Severe Burn Subjects
Study of tolerability and efficacy of BVS857 in severe burn subjects over 8 weeks and 15 weeks
- Trial name
- NCT02074995
- Testing
- BVS857
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Novartis Pharmaceuticals
Burns, Intensive Care
Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults
This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of…
- Conditions
- Burns, Intensive Care, Emergencies
- Trial name
- INDICIA (NCT06469970)
- Testing
- Glucose 30% Intravenous Solution
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Burns Greater Than 20% BSAB, Burns
Microbiome Changes in Severe Burns
The purpose of the study is characterizing changes in the microbiome of severely-injured adult patients as they progress through stages of injury, reconstruction, and recovery from burns.
- Trial name
- Microbiome (NCT03130868)
- Testing
- Characterizing changes in the microbiome
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- HealthPartners Institute
Microcirculation, Burns
A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury
The main objective of our study is to focus on the efficiency of standard fluid resuscitation in promoting tissue perfusion in severe burns patients (>15% TBSA).
- Conditions
- Microcirculation, Burns, Resuscitation
- Trial name
- MIPA (NCT04500197)
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Maasstad Hospital
Severe Burns, Fluid Resuscitation
Fluid Resuscitation in Burn Patients
Balanced solutions with low chloride concentration could represent an alternative to high chloride concentration solutions. Such balanced solutions contain other acid as buffers (i.e. acetate and/or gluconate).
- Trial name
- CARE (NCT03118362)
- Testing
- Plasmalyte, Ringer lactate
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burns
Children Severe Traumatic Skin Lesions and Functional Outcome
Traumatic skin lesions require an adapted and early patient care management
- Trial name
- NCT02804607
- Testing
- questionnaire
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Burns
Metabolic Rate in Burns
Severe burn patients are some of the most challenging critically ill patients with an extreme and continuous state of physiological stress.
- Trial name
- MrBurn (NCT03024931)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Stress, Psychological, Post-Traumatic Stress Disorder
Intervention to Reduce Stress in 0-5 Year Olds With Burns
The objectives of this study are to test and validate a simple, feasible intervention to reduce pediatric burn traumatic stress in 0-5 year old children and their parents.
- Conditions
- Stress, Psychological, Post-Traumatic Stress Disorder, Major Injury
- Trial name
- NCT00844896
- Testing
- DEF-only, DEF + COPE
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Massachusetts General Hospital
Burns
Antimicrobial Resistance of Bacteria in Burn Patients
The purpose of this study is to test the resistance of pathogenic bacteria in infected tissues of burn patients to various antimicrobials and enzyme debriders.
- Trial name
- NCT00794742
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Texas Tech University Health Sciences Center
Burns
Efficacy and Tolerance of Cellularised LG002 Versus Uncellularised LG002 in the Treatment of Severe Burns Injuries
After severe burn injury, the full-thickness burn areas are excised (in the first week) and then temporarily covered with allograft (cryogenic preserved cadaver skin).
- Trial name
- NCT00366041
- Testing
- Dermal substrate cellularised LG002 (10x10cm), Dermal substrate uncellularised LG002 (10x10 cm)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Laboratoires Genévrier
Severe Burn Injury
Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury
This observational study compares the influence of Ringer's Lactate solution and Ringer's Acetate solution on organ function scores following severe burn injury.
- Trial name
- VoLTRAB (NCT00609700)
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Klinikum St. Georg gGmbH
Third Degree Burn, Second Degree Burn
Diagnostic of Infections Following Major Abdominal Surgery and Burn Injury
This study was designed to investigate, if new biomarkers may improve the early diagnostic of infections following major abdominal surgery and severe burn injuries.
- Trial name
- Earlygnost (NCT01055587)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Klinikum St. Georg gGmbH
Burns
Effect of Music Therapy on Families of Burn Patients
The purpose of this study is to investigate the efficacy of music therapy in assisting with the coping and adjustment of children of adults with major burns.
- Trial name
- MTS3 (NCT00824681)
- Testing
- Sound Of Family Together (S.O.F.T.) Music Program, Non-Therapy Related Activities (NTRA)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- MetroHealth Medical Center
Burns
Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients
Proline is a non-essential amino acid that helps with collagen formation. Collagen is one of the main ingredients of skin, bone, tendons, and connective tissue.
- Trial name
- NCT00217035
- Testing
- TPN or TPN enriched with glutamine
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Burn Injury
Effect of n-3 PUFA From Fish in Enteral Nutrition of Major Burn Patients
Studies have shown that burn patients may benefit from low fat diets, but there is still no strong data regarding the impact of fatty acid composition used for feeding.
- Trial name
- OmegaBurn (NCT02189538)
- Testing
- ω-3 PUFA, Low fat enteral diet
- Where
- Uruguay
- Volunteers
- 100 people
- Sponsor
- Centro Nacional de Quemados, Uruguay
Burns
Investigation of the Effect of Exercise Protocol Determined According to Metabolic Rate in Early Burn Patients on Coagulation, Fibrinolytic Activity and Functional Capacity
The aim of this study is; To investigate the Effect of the Exercise Protocol Determined According to Metabolic Rate in Early Burn Patients on Coagulation, Fibrinolytic Activity and Functional Capacity, and to create an exercise…
- Trial name
- NCT04663113
- Testing
- Control Group/1st group ( standard physiotherapy, 2nd group- Standard physiotherapy + bicycle ergometer, 3rd group- Standard physiotherapy + exercise protocol to be developed
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Hasan Kalyoncu University
Patients With Major Burn Injury in Formosa FunCost Explosion
Outcome Evaluation for Burn Scar Therapy-laser and Surgery in Patients in Formosa Fun Coast Explosion
Protocol title： Outcome evaluation for burn scar therapy-laser and surgery in patients in Formosa Fun Coast Explosion Objectives： The goal of this study is to evaluate the effectiveness of both lasers and operations on patients…
- Trial name
- NCT03922399
- Testing
- Laser and Surgery
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Cancer, Breakthrough Pain
Efficacy/Safety Study of ACTIQ® for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP)
The primary objective of the study is to evaluate the efficacy of ACTIQ treatment for the management of breakthrough pain (BTP) compared to placebo treatment in children with cancer and non-cancer pain who are receiving…
- Trial name
- NCT00236041
- Testing
- ACTIQ®
- Where
- 31 sites in United States, Puerto Rico
- Volunteers
- 38 people
- Sponsor
- Cephalon
Burns
Determination of Nerve Growth Factor (NGF) Expression in Pediatric Patients With Severe Burns: a Pilot Study
The goal of this observational study is to determine the blood values of NGF in severely burned patients, to describe any changes over time and finally to correlate the expression of NGF to the severity of the burn.
- Trial name
- NCT05751174
- Testing
- pediatric patients affected by severe burns
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS