Clinical trials: Severe Burn
Severe Burns
Effect of Early Dexamethasone on Major Complications and All-cause Mortality in Severe Burns
Burns affect more than 11 million people worldwide each year. These injuries are responsible for severe morbidity resulting in a high societal burden and account for more than 180,000 yearly deaths especially in low- and…
- Trial name
- DEXA-BURN (NCT06968559)
- Testing
- Dexamethasone
- Where
- 10 sites in France
- Volunteers
- 478 people
- Sponsor
- Nantes University Hospital
Ocular Burns
Corneal Epithelial Autograft With Middle Lamellar Keratoplasty for Severe Ocular Burns
The purpose of this pilot study is to explore whether corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular surface…
- Trial name
- NCT03421769
- Testing
- EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yingfeng Zheng
Burns, Trauma
Continuous Glucose Monitoring (POC) in the ICU
The purpose of this study is to prospectively evaluate whether the addition of continuous glucose monitoring to point-of-care (POC) glucometer monitoring improves glucose control.
- Trial name
- POC (NCT00464386)
- Testing
- Continuous Glucose Monitoring
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- United States Army Institute of Surgical Research
Jugular Veins, Radial Artery
The Value of Central Venous-arterial Carbon Dioxide Difference
By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide [P (v-a) CO2] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P…
- Conditions
- Jugular Veins, Radial Artery, Carbon Dioxide
- Trial name
- NCT04761237
- Testing
- Goal-directed fluid therapy (GDET)
- Volunteers
- 118 people
- Sponsor
- Liang Bing
Cognitive Dysfunction, Burns
PRIME: Cognitive Outcome Following Major Burns
PRIME aims to demonstrate through neurocognitive assessment that BICU patients will have a degree of neurocognitive dysfunction following a major burn, that this neurocognitive dysfunction is due to an underlying…
- Conditions
- Cognitive Dysfunction, Burns, Inflammation, Brain, Quality of Life
- Trial name
- PRIME (NCT03242395)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Burn Injury, Psychosocial Problem
Effects of a Community Based Exercise Program in Adults With Severe Burns
The purpose of this proposal is to assess the efficacy of implementing a 12-week structured and supervised community-based exercise program (COMBEX) at hospital discharge.
- Conditions
- Burn Injury, Psychosocial Problem, Quality of Life
- Trial name
- COMBEX (NCT01184547)
- Testing
- Combex, Standard of Care
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hypothermia, Burns
Thermogard™ Efficacy Trial
The purpose of this study is to determine if the Thermogard™ central venous catheter can prevent hypothermia (defined as a core body temperature less then 36.0 °C) in severely burned patients who are undergoing surgery for…
- Trial name
- NCT00822796
- Testing
- Thermogard™, Standard central venous catheter
- Volunteers
- 9 people
- Sponsor
- Brooke Army Medical Center
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Burns
Assessment of Safety and Effectiveness of NovoSorb® BTM in Severe Burns
This is a multi-center, pivotal study to assess the safety and effectiveness of a new method of treating severe burns using NovoSorb® Biodegradable Temporizing Matrix (BTM).
- Trial name
- NCT04090424
- Testing
- NovoSorb BTM, Standard of Care
- Where
- 26 sites in United States, India
- Volunteers
- 150 people
- Sponsor
- PolyNovo Biomaterials Pty Ltd.
Burns
Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury
This study aimed to optimize fluid resuscitation with transpulmonary thermodilution (TPTD)-guided protocol and to lower the mortality rate of the severely burned.
- Trial name
- NCT05420610
- Testing
- Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable., Study group: TPTD device was implemented for monitoring.
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Chang Gung Memorial Hospital
Burns
Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Burns
The Total Parenteral Nutrition (TPN)received as part of your routine burn care has optimal levels of protein and sugar, however the best mixture of amino acids for a patient with burn wounds is not yet known.
- Trial name
- NCT00216996
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Burns
SASS 2 : Self Assembled Skin Substitute for the Autologous Treatment of Severe Burn Wounds in Acute Stage of Burn Trauma
This clinical trial is designed to assess the safety, effectiveness and benefits of Self Assembled Skin Substitute SASS grafts as a permanent skin replacement for the treatment of full-thickness burn wounds that require permanent…
- Trial name
- NCT02350205
- Testing
- Self assembled skin substitute (SASS)
- Where
- 8 sites in Canada
- Volunteers
- 52 people
- Sponsor
- CHU de Quebec-Universite Laval
Severe Burns, Acute Kidney Injury
Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT).
- Conditions
- Severe Burns, Acute Kidney Injury, Critical Illness
- Trial name
- CRRT-BURN (NCT07195565)
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Pinar Timur Tasci
Drug Clearance After Severe Burn Injury
Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries
Cefiderocol is a powerful, broad spectrum antibiotic approved to treat hospital-acquired or ventilator associated pneumonia and urinary tract infections.
- Trial name
- NCT07465432
- Testing
- Cefiderocol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Tennessee
Burn Degree Second, Burn Degree Third
The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients
The Swisskera project is a multicenter follow-up study at the three Swiss burn centers evaluating long-term outcomes after burn wound coverage with lab-grown epithelial grafts, specifically cultured epithelial autograft (CEA)…
- Conditions
- Burn Degree Second, Burn Degree Third, Skin Transplantation, Full Thickness Skin Defects
- Trial name
- Swisskera (NCT07415577)
- Testing
- Standard of Care (SOC)
- Where
- 3 sites in Switzerland
- Volunteers
- 236 people
- Sponsor
- University Children's Hospital, Zurich
Burn Injury
Amino Acid Supplementation in Recovery From Severe Burns
Exercise during recovery is now Standard of Care at Shriners Hospital for Children Galveston, since positive effects of exercise training were found on lean body mass and recovery after burns.
- Trial name
- ExAA (NCT01618630)
- Testing
- EAA Supplementation + Exercise Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burns, Physiotherapy
The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center's Experience
Background: This study planned to investigate the effect of early physiotherapy on biochemical parameters in major burn patients. Methods: Ten women (50%) and 10 men (50%) aged 21-47 years old were included in our study.
- Conditions
- Burns, Physiotherapy, Exercises
- Trial name
- NCT03520816
- Testing
- Burn Physiotherapy Protocol
- Volunteers
- 20 people
- Sponsor
- Hasan Kalyoncu University
Burns
Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury
RCT colloids versus cristalloids only in severe burn victims. Trial with medicinal product
- Trial name
- NCT01012648
- Testing
- Fluid resuscitation, HES 130/0.4 (6%), Voluven balanced vs. Lactated Ringer's solution
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Burn Scar
Microneedling for Burn Hypertrophic Scars
Approximately 33 to 91% of severe burn victims will develop hypertrophic scars. Hypertrophic scars are defined as erythematous (red), raised and rigid scars that can cause pain and itching, among other things.
- Trial name
- NCT05423613
- Testing
- Microneedling
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Injuries
Testing an Innovative Biomarker: Expression of HIF-1α and Its Isoforms in the Blood and Skin Tissue of Major Burns
Burn injury with full-thickness skin damage that encompass large body surface areas can induce local and systemic perturbations that are costly in terms of human suffering as well as in strains on the health care system.
- Trial name
- HIF (NCT02870439)
- Testing
- Blood drawn
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique Hopitaux De Marseille