Clinical trials: Severe Burn
Sepsis, Burns
Presepsin Diagnostic Performance in Severe Burn Sepsis
This study enrolls approximately 270 adult patients with severe burns covering at least 20% of total body surface area to evaluate how well the blood biomarker presepsin diagnoses sepsis early in this high-risk population.
- Trial name
- PSEP-BURNS (NCT07060560)
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Dohern Kym
Burns, Ascorbic Acid Deficiency
Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vitamin C
Burn injury is marked by a large release of inflammatory mediators which disrupt the normal capillary barrier and cause a rapid shift of intravascular fluid into interstitial spaces, ultimately leading to shock and death.
- Conditions
- Burns, Ascorbic Acid Deficiency, Burn Shock, Burn Degree Second
- Trial name
- NCT05612867
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Arrowhead Regional Medical Center
Burns, Growth Hormone Treatment
Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients
The investigators have previously demonstrated that burn injury causes severe muscle wasting, weight and height retardation, and systemic protein catabolism in pediatric and adult burned patients.
- Trial name
- NCT03038594
- Testing
- Somatropin, 0.09% Saline Solution
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Septic Shock, Severe Trauma
REAnimation Low Immune Status Markers
The fact that sepsis disrupts immune system homeostasis by inducing an initial cytokine storm, that participates to occurrence of organ failures and early death, followed by a compensatory anti-inflammatory response leading to…
- Conditions
- Septic Shock, Severe Trauma, Severe Burn, Major Surgery
- Trial name
- REALISM (NCT02638779)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Critical Illness, Nutritional Deficiency
Trace Element Repletion Following Severe Burn Injury
Major burn patients are characterized by large exudative losses of Cu, Se and Zn. Trace element (TE) repletion has been shown to improve clinical outcome.
- Conditions
- Critical Illness, Nutritional Deficiency, Trace Element Deficiency, Burn Injury
- Trial name
- NCT03204669
- Testing
- Trace elements replacement
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Stress Disorders, Post-Traumatic, Mood Disorders
Preventing Long Term Psychiatric Disability Among Those With Major Burn Injuries
The purpose of this study is to determine whether a newly developed, brief cognitive behavioral intervention, relative to supportive counseling, is effective in reducing acute stress disorder (ASD) and preventing post traumatic…
- Conditions
- Stress Disorders, Post-Traumatic, Mood Disorders, Sleep Disorders
- Trial name
- SMART (NCT00988104)
- Testing
- Cognitive Behavioral Therapy, Supportive Counseling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Burn
Propranolol in Severely Burned Children
To determine the safety and efficacy of administration of propranolol for reducing heart rate and blood pressure in burn injury.
- Trial name
- NCT01957449
- Testing
- Propranolol
- Where
- 4 sites in United States
- Volunteers
- 63 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Resuscitation, Burn
Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula
Burn injuries affecting ≥20% TBSA trigger major fluid shifts requiring aggressive fluid resuscitation to prevent burn shock. Traditional formulas such as the Parkland and Modified Brooke estimate initial 24-hour fluid needs, but…
- Trial name
- FLARE (NCT07307599)
- Testing
- Burn Navigator, Resuscitation (Voluven)
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Alnas Hospital
Barrett's Esophagus, High-grade Dysplasia in Barrett Esophagus
Eradicating Barrett's Esophagus Using Radiofrequency Ablation or a Novel Hybrid Argon Plasma Coagulation Technique
Lay summary: Barrett's Esophagus (BE) involves a change of the esophagus lining (BE epithelium) which in a small proportion of patients could be the starting point for the development of cancer (esophageal adenocarcinoma).
- Conditions
- Barrett's Esophagus, High-grade Dysplasia in Barrett Esophagus, Low Grade Dysplasia in Barrett Esophagus
- Trial name
- BURN (NCT03621319)
- Testing
- Hybrid argon plasma ablation (HAPC), Radiofrequency ablation (RFA)
- Where
- 13 sites in United States
- Volunteers
- 41 people
- Sponsor
- Erbe Elektromedizin GmbH
Burns
The RE-ENERGIZE Study: RandomizEd Trial of ENtERal Glutamine to minimIZE Thermal Injury
The purpose of this study is to test the following hypotheses: 1. Enteral glutamine administration decreases in-hospital mortality in adult patients with severe thermal burn injuries. 2.
- Trial name
- RE-ENERGIZE (NCT00985205)
- Testing
- Enteral Glutamine
- Where
- 53 sites in United States, Austria and 12 more
- Volunteers
- 1,201 people
- Sponsor
- Daren K. Heyland
Burns
Efficacy and Safety for Different Regimen of VTE Pharmacoprophylaxis Among Severely Burn Patients
This study aims to assess the feasibility and safety of VTE prophylaxis for 3 modality regimens (Unfractionated heparin 5000 U SQ q8 hours, Enoxaparin 40 mg SQ q24 hours or Enoxaparin 30 mg SQ q12 hours) in adult patients (≥18…
- Trial name
- NCT05237726
- Testing
- Enoxaparin 40 mg q24 hours, Enoxaparin 30 mg q12 hours, Unfractionated heparin 5000 U q8 hours
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- King Abdullah International Medical Research Center
Antibiotics, Severe Burn
Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients
At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required.
- Conditions
- Antibiotics, Severe Burn, Intensive Care
- Trial name
- MSBV (NCT03335137)
- Testing
- Drug Level Monitoring
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Schleswig-Holstein
Pain, Cancer
Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain
The objective of the study is to monitor the safety (adverse event data) of longer-term use of ACTIQ (Oral Transmucosal Fentanyl Citrate [OTFC]) treatment in children with pain associated with cancer, sickle cell disease, or…
- Conditions
- Pain, Cancer, Sickle Cell Anemia, Severe Burns
- Trial name
- NCT00236093
- Testing
- ACTIQ (Oral Transmucosal Fentanyl Citrate [OTFC])
- Where
- 28 sites in United States, Canada and 1 more
- Sponsor
- Cephalon
Pain, Burning
Ketamine Continuous Infusion on Opioid Consumption and Pain Management in Severe Burned Patients
The purpose of this study is to evaluate the efficacy of ketamine in continuous infusion in the control of pain intensity, the impact on the consumption of opioids and observe the side effect profile in patients suffering from…
- Trial name
- ccimb (NCT02860117)
- Testing
- Ketamine continuous infusion
- Where
- Brazil
- Sponsor
- University of Sao Paulo General Hospital
Syndecan 1, Severe Burn
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery.
- Conditions
- Syndecan 1, Severe Burn, Endotheliopathy of Trauma, Endothelial Glycocalyx
- Trial name
- GlycoBURN (NCT06670248)
- Testing
- Debridement Surgery, Sdc-1 Level Measurement
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Lymphedema of Upper Arm, Burns Chest Right Lateral
Kinesiotaping Versus Pressure Garments on Secondary Upper Extremity Lymphedema.
The goal of this randomised control study is to compare kinesiotaping and pressue garments in secondary upper extremity lymphedema following microsurgical breast reconstruction after severe chest burns.
- Conditions
- Lymphedema of Upper Arm, Burns Chest Right Lateral, Burns Chest Left Lateral
- Trial name
- NCT06230913
- Testing
- Kinesiotape, Pressure garment
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Burns, Liver Fibroses
Liver, Pancreas and Thyroid Function in Burn Patients
The purpose of this study is to determine the extent to which severe burn injuries affect the morphology and function of liver, pancreas and thyroid.
- Conditions
- Burns, Liver Fibroses, Pancreas Disease, Thyroid Diseases
- Trial name
- NCT03598283
- Testing
- Ultrasound/transient elastography
- Where
- United States
- Sponsor
- The University of Texas Medical Branch, Galveston
Burns
Proline Metabolism in Severely Burned Patients: Effect of Modulated Parenteral Feeding
The overall purpose of the study is to evaluate the effect of depleting proline supply in the nutritional support regimen on proline metabolism in the burn patients, this includes the rate of proline oxidation after burn injury…
- Trial name
- NCT00216983
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Burns, Thermal Injury
Optimal Heating Temperature in Major Burns Patients
pre and post intervention quasi-experimental epidemiological study without a control group will be carried out in large burned patients that will evaluate the influence on metabolic expenditure of the inclusion of active external…
- Conditions
- Burns, Thermal Injury, Nurse's Role
- Trial name
- NCT04396951
- Testing
- Active external overheating with heating plate, Aragonia ® MTC 400, Active external overheating with air blanket, Equator Level 1® de Smiths Medical
- Volunteers
- 34 people
- Sponsor
- University Rovira i Virgili
Burn, Growth
Bone Mineral Density, Body Composition and Growth Following Severe Burn Injury
The purpose of this study is two-fold. The first is to establish that bone mineral density is diminished among children admitted to this regional burn center as compared to healthy non-burned children.
- Conditions
- Burn, Growth, Malnutrition
- Trial name
- NCT00285090
- Testing
- Calcium, Vitamin D, Calcium,Vitamin D, Calcium, VitaminD
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kathy Prelack, PhD, RD