Clinical trials: Severe Burn Injury
Burns
Fluid Resuscitation in Patients Suffering From Burns Injury
This clinical study compares two fluid resuscitation treatments in patients suffering from burns injury. The treatments are Volulyte® and Human Serum Albumin (HSA) which will be administered as infusion solutions.
- Trial name
- NCT01689506
- Testing
- Volulyte, Human Serum Albumin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Fresenius Kabi
Burns
Assessment of Mechanisms of Improved Wound Healing
The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.
- Trial name
- NCT00673309
- Testing
- Stable Isotope Infusion study, Insulin High Dose, oxandrolone
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cancer, Breakthrough Pain
Efficacy/Safety Study of ACTIQ® for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP)
The primary objective of the study is to evaluate the efficacy of ACTIQ treatment for the management of breakthrough pain (BTP) compared to placebo treatment in children with cancer and non-cancer pain who are receiving…
- Trial name
- NCT00236041
- Testing
- ACTIQ®
- Where
- 31 sites in United States, Puerto Rico
- Volunteers
- 38 people
- Sponsor
- Cephalon
Burns
Antimicrobial Resistance of Bacteria in Burn Patients
The purpose of this study is to test the resistance of pathogenic bacteria in infected tissues of burn patients to various antimicrobials and enzyme debriders.
- Trial name
- NCT00794742
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Texas Tech University Health Sciences Center
Burn Injuries
Testing an Innovative Biomarker: Expression of HIF-1α and Its Isoforms in the Blood and Skin Tissue of Major Burns
Burn injury with full-thickness skin damage that encompass large body surface areas can induce local and systemic perturbations that are costly in terms of human suffering as well as in strains on the health care system.
- Trial name
- HIF (NCT02870439)
- Testing
- Blood drawn
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Severe Thermal Injury, Greater Than 20% TBSA
Vitamin C for Severe Thermal Injuries
Animal and human data have supported the notion that administration of large doses of Vitamin C has beneficial effects on those subjects suffering from large burns.
- Trial name
- NCT01587261
- Testing
- Vitamin C
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Burns
Effect of rFVIIa on Peri-operative Blood Loss in Patients Undergoing Major Burn
The purpose of the study is to see if a medication (Recombinant Coagulation Factor VIIa or NovoSeven), normally used to stop bleeding in persons with a bleeding disorder, will lower the amount of blood lost during burn surgery.
- Trial name
- NCT00243243
- Testing
- Recombinant Factor VIIa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Army Institute of Surgical Research
Burn Surgery, Dobutamine
Supernormal Oxygen Delivery for Patients With Severe Burns
This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the goal-directed fluid therapy group to further evaluate significant differences in rate of complications…
- Trial name
- NCT05241912
- Testing
- Dobutamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Red Cross Hospital
Burn Injury, Major Trauma
Study of Fibrinogen Metabolism During Severe Trauma and Burns
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
- Trial name
- NCT00588796
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- United States Army Institute of Surgical Research
Burn
High-Dose Vitamin D Deficiency in Burn Injury
High dose Vitamin D (50,000IU) therapy may increase bone mineral density/bone mineral content after large burns.
- Trial name
- VitaminD (NCT00591604)
- Testing
- Vitamin D
- Sponsor
- The University of Texas Medical Branch, Galveston
Energy Expenditure in Burn Children, Protein Turnover in Burn Children
Total Energy Expenditure, Protein Kinetics, and Body Composition in Recovering Burn Children.
The purpose of this study is to measure resting energy expenditure, total energy expenditure, and physical activity in recovering burn children to better understand their relation to impaired growth and nutritional status; and to…
- Trial name
- TEE (NCT01544868)
- Testing
- Use of Stable Isotope to Measure Energy Expenditure and Protein Turnover
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shriners Hospitals for Children
Burns
Efficacy and Tolerance of Cellularised LG002 Versus Uncellularised LG002 in the Treatment of Severe Burns Injuries
After severe burn injury, the full-thickness burn areas are excised (in the first week) and then temporarily covered with allograft (cryogenic preserved cadaver skin).
- Trial name
- NCT00366041
- Testing
- Dermal substrate cellularised LG002 (10x10cm), Dermal substrate uncellularised LG002 (10x10 cm)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Laboratoires Genévrier
Burn, Mechanical Ventilation
BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury
Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures.
- Conditions
- Burn, Mechanical Ventilation, Mechanical Ventilation Complication, ICU
- Trial name
- BURN-ASV (NCT07674563)
- Testing
- Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Jugular Veins, Radial Artery
The Value of Central Venous-arterial Carbon Dioxide Difference
By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide [P (v-a) CO2] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P…
- Conditions
- Jugular Veins, Radial Artery, Carbon Dioxide
- Trial name
- NCT04761237
- Testing
- Goal-directed fluid therapy (GDET)
- Volunteers
- 118 people
- Sponsor
- Liang Bing
Burns, Physiotherapy
The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center's Experience
Background: This study planned to investigate the effect of early physiotherapy on biochemical parameters in major burn patients. Methods: Ten women (50%) and 10 men (50%) aged 21-47 years old were included in our study.
- Conditions
- Burns, Physiotherapy, Exercises
- Trial name
- NCT03520816
- Testing
- Burn Physiotherapy Protocol
- Volunteers
- 20 people
- Sponsor
- Hasan Kalyoncu University
Burns, Pediatric Burns
Resistance, Plyometric, and Combined Exercise Training in Children With Severe Burns
Children who experience severe burns may continue to have reduced muscle strength, power, balance, and physical function after their wounds have healed.
- Conditions
- Burns, Pediatric Burns, Burn Injury
- Trial name
- NCT07843355
- Testing
- Traditional Resistance Training, Plyometric Training, Combined Resistance and Plyometric Training
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Qassim University
Burn, War-Related Injuries
ASV and Targeted Fluid Resuscitation in Severe Burns
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive…
- Conditions
- Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
- Trial name
- BURN-ASV/TFR (NCT07689097)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Burns
Xbox Kinect Promote Physical Fitness and Lean Mass in Severely Burned Children
The outcome measures included quadriceps muscle strength as measured using an isokinetic dynamometer, LBM is measured by DEXA and cardiopulmonary fitness was assessed by measuring VO2 peak during a standardized treadmill exercise…
- Trial name
- XboxBurn (NCT04350034)
- Testing
- Xbox training, Control group
- Volunteers
- 40 people
- Sponsor
- Qassim University
Burn
Bone Disease in Severely Burned Children
Bone metabolism is adversely affected by severe burns in children for a period of time.
- Trial name
- NCT00591162
- Testing
- Tetracycline, Duel Energy X-Ray Absorptiometry (DEXA), Bone Biopsy
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burns
The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections
This is a randomized controlled trial to compare viscoelastometric (VE) guided transfusion to standard practice transfusion in severe thermal injury burn excision on the utilization of blood products, effects on coagulation and…
- Trial name
- NCT03730415
- Testing
- Viscoelastic (VE) Guided Transfusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center