Clinical trials: Severe Obesity
Morbid Obesity
Effect of Gastric Balloon in Morbid Obesity: Prospective Study
The aim of this study is to compare the efficacy of gastric balloon in weight reduction among two different categories of morbidly obese people.
- Trial name
- NCT02128165
- Testing
- BMI more than 45 BMI, BMI less than 45 BMI
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Anastomotic Stricture, Morbid Obesity
Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery
The purpose of this study is to determine whether suppressing acid production by administration of daily proton pump inhibitors in the early post-operative period will reduce the gastrojejunal anastomosis stricture rate in…
- Trial name
- NCT00361985
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Morbid Obesity
Longitudinal Assessment of Bariatric Surgery
The goal of the LABS-1 study is to assess the short-term safety of bariatric surgery.
- Trial name
- LABS-1 (NCT00433810)
- Where
- 10 sites in United States
- Volunteers
- 5,102 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Depression - Major Depressive Disorder, Psychological Well Being
Peer-Supported E-Health Intervention for College Student Weight Management and Mental Health
This study will test whether adding peer support and online education can help college students manage their weight and improve their mood: we plan to enroll 300 full-time university students and randomly assign them to one of…
- Conditions
- Depression - Major Depressive Disorder, Psychological Well Being, Obesity Prevention
- Trial name
- NCT06966661
- Testing
- Peer Support Intervention, Peer Support and eHealth Intervention
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Jinan University Guangzhou
Morbid Obesity
Chronobiological Determinants of Gut Microbiome
The aim of this study is to examine how the number of daily eating occasions and the timing of energy intake influence gut microbiome composition in both morbidly obese and non-obese individuals.
- Trial name
- ChronoNutr (NCT07303036)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Obesity
Deep Brain Stimulation for Human Morbid Obesity
The burden of morbid obesity to the circulatory, endocrine, and locomotor systems, as well as the psychological effects and related health-care costs, are well established in the medical literature.
- Trial name
- BLESS (NCT02232919)
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Post Partum Hemorrhage
Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity
Postpartum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the most commonly used uterotonic drug for the active management of third stage labor, to reduce the risk of PPH and help deliver the placenta.
- Trial name
- NCT04902729
- Testing
- Carbetocin, Oxytocin
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Obesity
Pharmacokinetics, Safety, Tolerability and Efficacy of Intravenous Doses of ZGN-433 in Obese Female Volunteers
The purpose of this study is to assess whether multiple doses of ZGN-433 are safe and effective.
- Trial name
- NCT01372761
- Testing
- ZGN-433, Normal Saline
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zafgen, Inc.
Schizophrenia, Bipolar Disorder
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Adults with serious mental illness (SMI) are disproportionately affected by medical comorbidity, earlier onset of disease, and 10 to 25 years reduced life expectancy compared to the general population.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Recurrent, Obesity
- Trial name
- NCT04481737
- Testing
- Peer-delivered and Technology Support Integrated Illness Management and Recovery, Peer support
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Obesity, Type 2 Diabetes
Longitudinal Cohort Study Comparing 2 Surgical Techniques in Patients With Class 3 Obesity and Type 2 Diabetes
Wight loss surgery provides good glycemic control in type 2 diabetes. The technique of "Roux-en-Y gastric bypass" is more effective than the "Adjustable Gastric Band" on weight loss.
- Trial name
- OBEDIAB (NCT00688974)
- Testing
- Roux-en-Y gastric bypass, Adjustable gastric band
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Morbid Obesity
Dosing Obese With Noxafil® Under a Trial (DONUT)
Although posaconazole is approved for the prophylaxes and treatment of invasive fungal infections, specific dosing guidelines for posaconazole in (morbidly) obese patients are not specified.
- Trial name
- DONUT (NCT03246386)
- Testing
- Posaconazole Injection [Noxafil] 300mg, Posaconazole Injection [Noxafil] 400mg
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Mental Illness Persistent, Chronic Disease
Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border
This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months…
- Conditions
- Mental Illness Persistent, Chronic Disease, Hypertension, Diabetes
- Trial name
- NCT03881657
- Testing
- Reverse Colocated Integrated Care, Usual Care
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Health Resources in Action, Inc.
Arterial Embolization, Other Surgical Procedures
Gastric Artery Embolization Trial for Lessening Appetite Nonsurgically
The purpose of this pilot study is to achieve the collection of safety and efficacy data in patients undergoing left gastric artery embolization for morbid obesity in the United States.
- Conditions
- Arterial Embolization, Other Surgical Procedures, Obesity
- Trial name
- GETLEAN (NCT02248688)
- Testing
- BeadBlock 300 - 500 Micron, Left Gastric Artery Embolization
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Dayton Interventional Radiology
Physical Capacity, Leg Strength
The Effect of Lifestyle Treatment in Patients With Morbid Obesity
The effect of lifestyle treatment on physical capacity, maximal strength, eating behavior and quality of life in patients with morbid obesity (LIFETIME)
- Conditions
- Physical Capacity, Leg Strength, Eating Behavior, Life of Quality
- Trial name
- LIFETIME (NCT03593148)
- Testing
- Lifestyle
- Where
- Norway
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sykehuset i Vestfold HF
Severe Obesity
Adherence to Walking on an Alter G Anti-Gravity Treadmill
Several barriers to exercise are present that need to be addressed. Morbidly obese individuals experience more skin friction, urinary stress incontinence, knee pain, low back pain, and hip arthritis than the lean population…
- Trial name
- NCT03690752
- Testing
- unweighting using Alter-G Anti-Gravity Treadmill, normal weight using Alter-G Anti-Gravity Treadmill
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Morbid Obesity
Sleeve Gastrectomy: Outcome, Morbidity and Mortality. A Multicentric Retrospective Trial
Laparoscopic sleeve gastrectomy (LSG) is currently the most frequent primary bariatric procedure performed worldwide. LSG is a safe and effective technique in terms of excess weight loss and it is, moreover, a powerful metabolic…
- Trial name
- PSICHE (NCT04643262)
- Testing
- Sleeve Gastrectomy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Depressive Disorder, Major
The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Major Depressive Disorder
The present study investigates the effect of Mediterranean Diet and Mindful Eating on depression severity in people with obesity and major depressive disorder.
- Trial name
- MEDIMIND (NCT06621394)
- Testing
- nutritional intervention, Mindful Eating, Attention Control
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Bariatric Surgery Candidate, Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting After Bariatric Surgery
Postoperative nausea and vomiting are common occurrences following bariatric surgery, occurring in up to 80% of patients and contributing to increased healthcare utilization and delays in discharge.
- Conditions
- Bariatric Surgery Candidate, Postoperative Nausea and Vomiting, Morbid Obesity
- Trial name
- NCT04644445
- Testing
- Bariatric Full Liquid Diet
- Where
- 2 sites in United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University