Clinical trials: Severe Pre-eclampsia
Fetal Growth Restriction, Preeclampsia Severe
Expanded NIPT for Pregnancy Complications
This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including…
- Trial name
- NCT04311749
- Testing
- Expanded panel cell free DNA testing (non-invasive prenatal testing), Placental biopsy, Umbilical cord blood
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Severe Pre-eclampsia
Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia.
The only effective treatment of severe preeclampsia is delivery of the fetus but immediate antihypertensive treatment is given to stabilize the patient and prevent further complications.
- Trial name
- NCT06385600
- Testing
- Labetalol, Phentolamine
- Volunteers
- 200 people
- Sponsor
- Assiut University
Pre-eclampsia
Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia
OBJECTIVES: I. Determine the effectiveness of nimodipine versus magnesium sulfate in the prevention of eclamptic seizures in patients with severe preeclampsia.
- Trial name
- NCT00004399
- Testing
- magnesium sulfate, nimodipine
- Volunteers
- 2,000 people
- Sponsor
- FDA Office of Orphan Products Development
Severe Preeclampsia
Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia
Preeclampsia is commonly viewed as one of the hypertensive pregnancy disorders, which cover a spectrum of clinical presentations from chronic hypertension ( hypertension occurring prior to 20 weeks of gestation) and gestational…
- Trial name
- NCT03164304
- Testing
- Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 222 people
- Sponsor
- Assiut University
Pre-Eclampsia
Optic Nerve Sheath Diameter for Volume Status Prediction in Severe Preeclampsia
A quick, non-invasive, bedside test to assess fluid status of patients with severe preeclampsia would be very helpful to ICU clinicians severe preeclampsia is associated with an increase in extravascular lung water (EVLW), which…
- Trial name
- NCT04367519
- Testing
- Ultrasound measurement of Optic nerve sheath diameter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Preeclampsia
KW-3357 Study in Patients With Early Onset Severe Preeclampsia
The purpose of this study is to evaluate the efficacy of intravenous KW-3357 in patients with early-onset severe preeclampsia by comparing the prolongation days of pregnancy with that of placebo.
- Trial name
- NCT04182373
- Testing
- Antithrombin gamma, physiological saline
- Where
- 63 sites in Japan
- Volunteers
- 181 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Preeclampsia, Preeclampsia Severe
Preeclampsia Educational Program Study (PrEPS)
Preeclampsia complicates approximately 8% of all pregnancies. A critical factor of outpatient monitoring is patient education; specifically, education regarding nature of the disease, ongoing short- and long-term risks, and…
- Conditions
- Preeclampsia, Preeclampsia Severe, Preeclampsia Mild, Preeclampsia Postpartum
- Trial name
- PrEPS (NCT06373367)
- Testing
- Illustration based application, Text based application
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- MemorialCare Health System
Severe Preeclampsia
Serum Androgen Levels as a Marker for the Severity of Preeclampsia
this study will be conducted to confirm the hypothesis of the previous studies and to list the high androgen levels as a precipitating factor for preeclampsia
- Trial name
- NCT03744988
- Testing
- serum androgen levels
- Where
- 2 sites in Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pre-eclampsia, Pre-Eclampsia, Severe
Prevalence of Blood Pressure Complications During Cesarean Section in Pre-eclamptic Patients (HOPE)
Preeclampsia (PE) is an obstetric placental vascular pathology with a prevalence of 2 to 5% of pregnant women. It is defined by learned societies by the association of high blood pressure (BP≥140/90mmHg) and proteinuria \&gt…
- Trial name
- HOPE (NCT06588023)
- Testing
- Observational study to evaluate professional practices
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Preeclampsia
Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia
The hypothesis of this study is that many plasma proteins are altered in concentration and structure in preeclampsia and the elucidation of these alterations will add to the poorly understood pathophysiology of preeclampsia.
- Trial name
- NCT00719654
- Where
- United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Preeclampsia, Severe Preeclampsia
First-trimester Prediction of Preeclampsia
Preeclampsia is a complication of pregnancy related to adverse maternal and neonatal outcomes, including fetal growth restriction and perinatal death.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PREDICTION (NCT02189148)
- Where
- 4 sites in Canada
- Volunteers
- 7,554 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Pulmonary Edema
Predictors of Pulmonary Edema in Severe Preeclampsia
Pre-eclampsia is a multisystem major cardiovascular disease of pregnancy with hypertension its main clinical manifestation. Acute pulmonary edema, which signifies severe disease, is a leading cause of death in women with…
- Trial name
- NCT05095974
- Testing
- ultrasonography, echocardiography, thoracic electrical bioimpedence
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertension, Preeclampsia
The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine
The objective of this study is to demonstrate that urapidil is not inferior to nicardipine for the treatment of hypertension associated with preeclampsia (PE) and that it is better tolerated.
- Trial name
- Uranic (NCT02558023)
- Testing
- Urapidil, Nicardipine
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Pre-eclampsia, Postpartum Condition or Complication
Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol
We aim to compare carbetocin with misoprostol for the prevention of postpartum hemorrhage in patients with severe preeclampsia. The primary outcome is postpartum haemorrhage (blood loss of ≥ 500 ml) while our Secondary outcomes…
- Trial name
- carbetocin (NCT02086994)
- Testing
- misoprostol, carbetocin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- khalid abd aziz mohamed
Post Partum Severe Preeclampsia
Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia
There is no evidence that patients receiving magnesium sulfate before birth are required to maintain the drug for 24 hours. Therefore the investigators will have a randomized clinical study in patients with severe preeclampsia…
- Trial name
- MAG-PIP (NCT02307201)
- Testing
- Magnesium Sulfate
- Where
- 9 sites in Dominican Republic, Ecuador and 3 more
- Volunteers
- 1,114 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Preeclampsia, Hypertensive Disorder of Pregnancy
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications
- Trial name
- HHD (NCT05655936)
- Testing
- Heart Health Doula Intervention Program, Usual Care
- Where
- United States
- Volunteers
- 454 people
- Sponsor
- University of Pittsburgh
Preeclampsia, Severe Preeclampsia
Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women
The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals.
- Trial name
- NCT07265336
- Testing
- Arterial Blood gases
- Where
- Panama
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saint Thomas Hospital, Panama
Severe Preeclampsia, Antiphospholipid Syndrome
Antiphospholipid Antibodies and Early Severe Preeclampsia.
The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and…
- Trial name
- NCT01538121
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia, Preeclampsia Severe
Risk Prediction Model of Preeclampsia
Preeclampsia is the main cause of increased maternal and perinatal mortality during pregnancy. Preeclampsia is mainly manifested as hypertension, urine protein, or damage symptoms of other target organs after 20 weeks of…
- Trial name
- NCT04794855
- Testing
- laboratory tests
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Peking University Third Hospital