Clinical trials: Severe Sepsis With Septic Shock
Severe Sepsis
Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial
The ARISE RCT is a multi-centre, randomised, controlled trial of EGDT compared to standard care in patients with severe sepsis presenting to the ED.
- Trial name
- ARISE (NCT00975793)
- Testing
- Early Goal Directed Therapy (EGDT)
- Where
- 51 sites in Australia, Finland and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Belinda Howe
Severe Sepsis, Septic Shock
Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock
OBJECTIVES. To establish the therapeutic efficiency of melatonin in adult patients with severe sepsis and septic shock. Specifically: 1.
- Trial name
- NCT01858909
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Aragon Institute of Health Sciences
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Sepsis, Septic Shock
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
The global burden of sepsis is substantial with an estimated 15 to 19 million cases per year; the vast majority of these cases occur in low income countries.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Fluid Overload
- Trial name
- NCT03335124
- Testing
- Vitamin C, Hydrocortisone, Thiamine
- Where
- Slovenia
- Volunteers
- 5 people
- Sponsor
- University Medical Centre Ljubljana
Sepsis
Endotoxin Adsorber Hemoperfusion and Microcirculation
Despite maintaining adequate mean arterial pressure and central venous oxygen saturation, the mortality is still high in severe sepsis and septic shock.
- Trial name
- NCT01756755
- Testing
- PMX-20R Hemoperfusion
- Where
- 3 sites in Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Severe Sepsis, Septic Shock
Scandinavian Starch for Severe Sepsis/Septic Shock Trial
By tradition hydroxyethyl starch (HES) is used to obtain fast circulatory stabilisation in critically ill. High molecular weight HES may, however, cause acute kidney failure in patients with severe sepsis.
- Trial name
- 6S (NCT00962156)
- Testing
- 6% Hydroxyethyl starch 130/0.4, Ringers acetate
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 804 people
- Sponsor
- Anders Perner
Sepsis, Septic Shock
De-resuscitation Informed by Ultrasound for Patients With Sepsis
Randomized, unblinded clinical trial of 152 critically ill patients with sepsis admitted to the intensive care unit. The primary determine if using the Venous Excess Ultrasound Score (VExUS) to guide fluid deresuscitation in…
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Volume Overload
- Trial name
- DRI-US (NCT04921319)
- Testing
- VExUS score
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The Miriam Hospital
ARDS, Septic Shock
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation
to evaluate the effect of use of bronchoscopy in the course of sepsis, weaning from the ventilator, duration of ICU stays and mortality rate in septic patients with ARDS due to VAP.
- Trial name
- NCT04553367
- Testing
- Meropenem, bronchoscopy, ventilator
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- King Abdul Aziz Specialist Hospital
New Onset Atrial Fibrillation, Severe Sepsis
Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock
Purpose/Objectives: Severe sepsis and septic shock are a common cause of new onset atrial fibrillation (NOAF) in the intensive care unit. Development of NOAF in this setting can prolong length of stay and increase mortality.
- Conditions
- New Onset Atrial Fibrillation, Severe Sepsis, Septic Shock
- Trial name
- NCT02668432
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Sepsis, Severe Sepsis
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
In this study, the investigators will dynamically detect the expression of an immune regulator- T cell Ig and mucin domain protein 3 (Tim-3) in patient with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02180009
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Severe Sepsis With Septic Shock
Evaluating a CytoSorb Score in Septic Shock
Systemic hyperinflammatory states, e.g. triggered by infection/sepsis, represent a major challenge for modern medicine. After an initially localized onset, inflammation can extend to an excessive, uncontrolled inflammatory…
- Trial name
- ECSISS (NCT03977688)
- Testing
- Cytokin Adsorption
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Klinikum Emden
Severe Sepsis and Septic Shock
Statistical Analysis Plan for an Individual Patient Data Meta-analysis of Three, International Trials Comparing Protocolised With Usual Resuscitation in Patients Presenting to the Emergency Department With Severe Sepsis and Septic Shock
This is the statistical analysis plan for an individual patient data meta-analysis (IPDMA) of three EGDT clinical trials.
- Trial name
- NCT02030158
- Volunteers
- 4,210 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Sepsis
Pharmacokinetic/Pharmacodynamic Evaluation Amikacin in Critically Ill Patients Admitted at the Emergency Department
The aim of the study is the evaluation of PK/PD target attainment of amikacin in ED patients with severe sepsis and septic shock.
- Trial name
- NCT02365272
- Testing
- Amikacin
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Intensive Care Units, Infection
Citrulline and Arginase Activity in Severe Sepsis and Septic Shock
Sepsis is an acute pathology defined as an inappropriate response of the host to infection, resulting in the onset of organ failure (Quick SOFA ≥2, or SOFA ≥2).
- Conditions
- Intensive Care Units, Infection, Biomarkers, Sepsis
- Trial name
- CARS (NCT03837730)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Severe Sepsis or Septic Shock
Effects of Early Exercise Rehabilitation on Long-term Functional Recovery in Patients With Severe Sepsis
We hypothesized that early exercise rehabilitation for patients with severe sepsis or septic shock would decrease their functional disability and cognitive impairment.
- Trial name
- NCT01845766
- Testing
- exercise rehabilitation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Sepsis, Sepsis and Septic Shock
Role of Transposable Elements in Septic Immune Aging
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction
- Trial name
- SITE (NCT06809868)
- Testing
- RNA and DNA Sequencing
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Septic Shock, Sepsis, Severe
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
The sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies.
- Trial name
- suPAR (NCT04459572)
- Testing
- suPAR
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Early Phase of Severe Sepsis and Septic Shock
Piperacillin/Tazobactam in Critically Ill Patients With Severe Sepsis and Septic Shock
This is prospective study to assess the pharmacodynamics (t>MIC) of 4.5 g every 6 h of piperacillin/tazobactam in patients with early phase of severe sepsis/septic shock following administration by a 30 min infusion.
- Trial name
- NCT02730624
- Testing
- Piperacillin-tazobactam
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Sutep Jaruratanasirikul
Septic Shock, Acute Renal Failure (as Defined by the "Failure" Stage of the RIFLE Classification)
I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit)
The purpose of this multicentric, randomized controlled trial is to assess whether the timing of renal replacement therapy initiation (early vs delayed) has an impact on mortality at 90 days in patients with severe acute kidney…
- Trial name
- IDEAL-ICU (NCT01682590)
- Testing
- Renal Remplacement Therapy
- Where
- 27 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Severe, Septic
Effects of Alkaline Phosphatase on Renal Function in Septic Patients
Septic shock is the most common cause of death in patients requiring intensive care. The kidney is one of the first organs to fail, stressing the importance to search for clinical interventions that may protect the kidneys during…
- Conditions
- Severe, Septic, Shock
- Trial name
- NCT00457613
- Testing
- bolus injection, followed by a continuous infusion ( 24 h) (Alkaline phosphatase)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center