Clinical trials: Severe Skin Burns
Burn Injuries
Testing an Innovative Biomarker: Expression of HIF-1α and Its Isoforms in the Blood and Skin Tissue of Major Burns
Burn injury with full-thickness skin damage that encompass large body surface areas can induce local and systemic perturbations that are costly in terms of human suffering as well as in strains on the health care system.
- Trial name
- HIF (NCT02870439)
- Testing
- Blood drawn
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Severe Skin Burns
Hematocrit Evolution in Severe Burns
Burn-induced shock is described as being superimposed on sterile shock. with an increase in capillary permeability affecting healthy and burnt tissue and explains the formation of a large third sector.
- Trial name
- HEREBUS (NCT05569499)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Burn Degree Second, Burn Degree Third
The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients
The Swisskera project is a multicenter follow-up study at the three Swiss burn centers evaluating long-term outcomes after burn wound coverage with lab-grown epithelial grafts, specifically cultured epithelial autograft (CEA)…
- Conditions
- Burn Degree Second, Burn Degree Third, Skin Transplantation, Full Thickness Skin Defects
- Trial name
- Swisskera (NCT07415577)
- Testing
- Standard of Care (SOC)
- Where
- 3 sites in Switzerland
- Volunteers
- 236 people
- Sponsor
- University Children's Hospital, Zurich
Burn Injury, Physical Injury
STAT: Standard Therapy Plus Active Therapy
The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury.
- Conditions
- Burn Injury, Physical Injury, Thermal Burn
- Trial name
- STAT (NCT04368117)
- Testing
- Physical Therapy
- Where
- 7 sites in United States
- Volunteers
- 166 people
- Sponsor
- American Burn Association
Burns
Children Severe Traumatic Skin Lesions and Functional Outcome
Traumatic skin lesions require an adapted and early patient care management
- Trial name
- NCT02804607
- Testing
- questionnaire
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Burns
Assessment of Safety and Effectiveness of NovoSorb® BTM in Severe Burns
This is a multi-center, pivotal study to assess the safety and effectiveness of a new method of treating severe burns using NovoSorb® Biodegradable Temporizing Matrix (BTM).
- Trial name
- NCT04090424
- Testing
- NovoSorb BTM, Standard of Care
- Where
- 26 sites in United States, India
- Volunteers
- 150 people
- Sponsor
- PolyNovo Biomaterials Pty Ltd.
Morality, Skin Graft Complications
Retrospective Analysis of Spray Skin Treats for Severe Burns
This study investigated the efficacy of novel approach spray skin for extensive severe burns treatment.
- Trial name
- NCT06170424
- Testing
- spray skin, Control group
- Where
- China
- Volunteers
- 85 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Burn
Microbiota in Children With Severe Burn Injury
The research protocol consists of taking aliquots of biological specimens from skin swabs, nasopharyngeal swabs, and fecal swabs.
- Trial name
- MIBUS (NCT07098377)
- Testing
- nasopharyngeal swab for biological sample analysis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Deep Full-thickness Burn Injury (Disorder)
Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds
This is a Phase 1/2, Open-label, Multi-center, Clinical Trial to evaluate the safety, tolerability, and efficacy of realSKIN® to provide complete wound closure of severe and extensive deep-partial and full-thickness burn wounds.
- Trial name
- NCT03695939
- Testing
- realSKIN (skin xenotransplant), Human Cadaver Allograft
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- XenoTherapeutics, Inc.
Burns
SASS 2 : Self Assembled Skin Substitute for the Autologous Treatment of Severe Burn Wounds in Acute Stage of Burn Trauma
This clinical trial is designed to assess the safety, effectiveness and benefits of Self Assembled Skin Substitute SASS grafts as a permanent skin replacement for the treatment of full-thickness burn wounds that require permanent…
- Trial name
- NCT02350205
- Testing
- Self assembled skin substitute (SASS)
- Where
- 8 sites in Canada
- Volunteers
- 52 people
- Sponsor
- CHU de Quebec-Universite Laval
Burn Scar
Microneedling for Burn Hypertrophic Scars
Approximately 33 to 91% of severe burn victims will develop hypertrophic scars. Hypertrophic scars are defined as erythematous (red), raised and rigid scars that can cause pain and itching, among other things.
- Trial name
- NCT05423613
- Testing
- Microneedling
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)