Clinical trials: Severely Burned Patients
Burns
Fluid Resuscitation in Patients Suffering From Burns Injury
This clinical study compares two fluid resuscitation treatments in patients suffering from burns injury. The treatments are Volulyte® and Human Serum Albumin (HSA) which will be administered as infusion solutions.
- Trial name
- NCT01689506
- Testing
- Volulyte, Human Serum Albumin
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Fresenius Kabi
Burns
Assessment of Mechanisms of Improved Wound Healing
The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.
- Trial name
- NCT00673309
- Testing
- Stable Isotope Infusion study, Insulin High Dose, oxandrolone
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burns
Antimicrobial Resistance of Bacteria in Burn Patients
The purpose of this study is to test the resistance of pathogenic bacteria in infected tissues of burn patients to various antimicrobials and enzyme debriders.
- Trial name
- NCT00794742
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Texas Tech University Health Sciences Center
Severely Burned Patients
HLA Sensitization in Severely Burned Patients
Primary goal of this study is the analysis of HLA (Human leucocyte antigen) formation in severly burned patients. Potential HLA triggers in the treatment of severely burned patients are blood products, assist devices or temporary…
- Trial name
- NCT02537821
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Burns
Effect of rFVIIa on Peri-operative Blood Loss in Patients Undergoing Major Burn
The purpose of the study is to see if a medication (Recombinant Coagulation Factor VIIa or NovoSeven), normally used to stop bleeding in persons with a bleeding disorder, will lower the amount of blood lost during burn surgery.
- Trial name
- NCT00243243
- Testing
- Recombinant Factor VIIa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Army Institute of Surgical Research
Burn Surgery, Dobutamine
Supernormal Oxygen Delivery for Patients With Severe Burns
This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the goal-directed fluid therapy group to further evaluate significant differences in rate of complications…
- Trial name
- NCT05241912
- Testing
- Dobutamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Red Cross Hospital
Burn Injury, Major Trauma
Study of Fibrinogen Metabolism During Severe Trauma and Burns
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
- Trial name
- NCT00588796
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- United States Army Institute of Surgical Research
Jugular Veins, Radial Artery
The Value of Central Venous-arterial Carbon Dioxide Difference
By observing the changes of Central venous-arterial partial pressure difference of carbon dioxide [P (v-a) CO2] in liquid resuscitation during early escharectomy in patients with large-scale burns, We investigate the effect of P…
- Conditions
- Jugular Veins, Radial Artery, Carbon Dioxide
- Trial name
- NCT04761237
- Testing
- Goal-directed fluid therapy (GDET)
- Volunteers
- 118 people
- Sponsor
- Liang Bing
Burns, Physiotherapy
The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center's Experience
Background: This study planned to investigate the effect of early physiotherapy on biochemical parameters in major burn patients. Methods: Ten women (50%) and 10 men (50%) aged 21-47 years old were included in our study.
- Conditions
- Burns, Physiotherapy, Exercises
- Trial name
- NCT03520816
- Testing
- Burn Physiotherapy Protocol
- Volunteers
- 20 people
- Sponsor
- Hasan Kalyoncu University
Burn, War-Related Injuries
ASV and Targeted Fluid Resuscitation in Severe Burns
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive…
- Conditions
- Burn, War-Related Injuries, Mechanical Ventilation, Infusion Fluid
- Trial name
- BURN-ASV/TFR (NCT07689097)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Severe Skin Burns
Hematocrit Evolution in Severe Burns
Burn-induced shock is described as being superimposed on sterile shock. with an increase in capillary permeability affecting healthy and burnt tissue and explains the formation of a large third sector.
- Trial name
- HEREBUS (NCT05569499)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Syndecan 1, Severe Burn
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery.
- Conditions
- Syndecan 1, Severe Burn, Endotheliopathy of Trauma, Endothelial Glycocalyx
- Trial name
- GlycoBURN (NCT06670248)
- Testing
- Debridement Surgery, Sdc-1 Level Measurement
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Burns, Trauma
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers.
- Trial name
- NCT01812941
- Testing
- trauma: blood collection, healthy volunteers: blood collection, Burn: blood collection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Peer Bullying Intervention, Vodcast
Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn Patients
The purpose of this study is to evaluate the impact of an avatar-supported, teacher-student interactive, vodcast-based peer bullying prevention program-developed for adolescents-on students' ability to identify peer bullying…
- Conditions
- Peer Bullying Intervention, Vodcast, Students
- Trial name
- SIC-BURN-JAAM2 (NCT07905807)
- Testing
- Vodcast-Based Peer Bullying Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Burn Degree Second, Burn Degree Third
The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients
The Swisskera project is a multicenter follow-up study at the three Swiss burn centers evaluating long-term outcomes after burn wound coverage with lab-grown epithelial grafts, specifically cultured epithelial autograft (CEA)…
- Conditions
- Burn Degree Second, Burn Degree Third, Skin Transplantation, Full Thickness Skin Defects
- Trial name
- Swisskera (NCT07415577)
- Testing
- Standard of Care (SOC)
- Where
- 3 sites in Switzerland
- Volunteers
- 236 people
- Sponsor
- University Children's Hospital, Zurich
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen in Major Burn Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in major burn patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534972)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Colorado, Denver
Severely Burned Patients, Gut Microbiota Diversity and Composition
Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury
The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples.
- Conditions
- Severely Burned Patients, Gut Microbiota Diversity and Composition, Inflammatory Responses
- Trial name
- microbiome (NCT07329595)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Tamas Vegh, MD
Burns
Inflammatory Consequences of Crystalloids in Severely Burned Patients
This is a pilot study, but the investigators will also observe key immunological events with potential significance. The global objective is to study the inflammatory profiles of PlasmaLyte and Ringer's Lactate used in the…
- Trial name
- NCT04893382
- Testing
- PlasmaLyte for fluid resuscitation, Ringer's Lactate for fluid resuscitation
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Injury, Physical Injury
STAT: Standard Therapy Plus Active Therapy
The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury.
- Conditions
- Burn Injury, Physical Injury, Thermal Burn
- Trial name
- STAT (NCT04368117)
- Testing
- Physical Therapy
- Where
- 7 sites in United States
- Volunteers
- 166 people
- Sponsor
- American Burn Association
Burns, Scar
Aquatic Training in Patients With Severe Scarring
Aim: to investigate the effects of an aquatic exercise program in patients with severe scars Patient population: 10 patients of at least 18 years old patients with scars after burns or other severe skin injuries stratification…
- Trial name
- NCT01433198
- Testing
- Aquatic training
- Sponsor
- Universitaire Ziekenhuizen KU Leuven