Clinical trials: Sex Differences
Vasodilation, Hypoxia
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
- Trial name
- NCT05256069
- Testing
- Propranolol Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Heat Intolerance, Heat Stress
Acquiring and Targeting Heat Exposures Necessary for Action
The purpose of this research study is to better understand ways that women and men differ physiologically, cognitively, physically, and cellularly to better prescribe helpful interventions that will prevent injury and risk of…
- Conditions
- Heat Intolerance, Heat Stress, Fatigue; Heat
- Trial name
- ATHENA (NCT05678738)
- Testing
- Antioxidant Berry Supplementation, Acute and Chronic Exercise-Heat Stress
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Position Sense, Sex Characteristics
Shoulder Proprioception: a Comparative Study on Hand Dominance and Sex
The goal of this cross-sectional study is to examine the differences in proprioception sensation depending on sex and dominant side factors in healthy volunteers.
- Conditions
- Position Sense, Sex Characteristics, Glenohumeral Joint, Upper Extremity
- Trial name
- NCT06602427
- Testing
- Shoulder proprioception measurement using isokinetic dynamometer
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Sleep Deprivation, Sex Differences
Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment
The goal of this study is to learn whether insufficient sleep affects glucose metabolism differently in healthy men and women.
- Conditions
- Sleep Deprivation, Sex Differences, Glucose Tolerance
- Trial name
- NCT06809023
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mental Stress, Myocardial Ischemia
Heart-brain-axis and Psychosocial Stress
The main study objective is to prospectively determine the influence of sex-related risk factors and psychosocial variables on neuronal stress responses and myocardial perfusion in a population of 64 female and male individuals…
- Conditions
- Mental Stress, Myocardial Ischemia, Sex Role, Gender
- Trial name
- NCT06345573
- Testing
- Mental stress
- Where
- Switzerland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Malocclusion, Quality of Life
The Effect of Malocclusions on Oral Health Related Quality of Life
Malocclusions in adolescents may affect oral health related quality of life. The study aims at; 1. Evaluating two instruments measuring oral health related quality of life; "Child Perceptions Questionnaire 11-14" (CPQ 11-14)…
- Conditions
- Malocclusion, Quality of Life, Orthodontics, Adolescent
- Trial name
- NCT05038865
- Testing
- Malocclusion and Orthodontic Treatment
- Where
- 3 sites in Sweden
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- Malmö University
Physical Performance, Pain
Effect of Ski Sport on Physical Performance
The aim of the study is to investigate the effect of ski sport on physical performance, pain, and quality of life compared to sedentary individuals of similar age groups and to examine the existence of gender-specific differences.
- Conditions
- Physical Performance, Pain, Quality of Life
- Trial name
- NCT04913844
- Testing
- Physical performance tests and observational assessments
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cardiovascular
The Role of EDHFs on Blood Pressure Following a Bout of Prolonged Sitting
Canadians spend most of their day in sedentary postures (i.e., sitting, lying, reclining). While the beneficial impacts of physical activity on the heart are well-established, less is known about the consequences during time…
- Trial name
- NCT07396857
- Testing
- Fluconazole 150 mg
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Pharmacokinetics of New Curcumin Formulations, Safety of New Curcumin Formulations
Improved Oral Bioavailability of Curcumin Incorporated Into Micelles
Curcumin, a lipophilic polyphenol derived from the plant curcuma longa possesses numerous health-promoting activities. The oral bioavailability of curcumin is low due to its poor aqueous solubility, limited gastrointestinal…
- Trial name
- NCT01982734
- Testing
- curcumin
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Interoception, Perceived Stress
Interoceptive Awareness, Perceived Stress, and Physical Performance in Sport Sciences Students
This cross-sectional observational study examined the relationships between interoceptive awareness, perceived stress, state and trait anxiety, sleep quality, and physical performance indicators in university-level sport sciences…
- Conditions
- Interoception, Perceived Stress, Anxiety, Sleep Quality
- Trial name
- NCT07696234
- Testing
- Psychological and Physical Performance Assessment Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Inonu University
Human Papillomavirus (HPV) Vaccination, Message Framing
THE EFFECTS OF HPV VACCİNATİON AND MESSAGE FRAMİNG
Background: University students are at high risk for HPV infection, while HPV vaccination rates remain low. Message framing strategies may influence vaccination-related perceptions and intentions.
- Conditions
- Human Papillomavirus (HPV) Vaccination, Message Framing, Vaccination Intention
- Trial name
- NCT07614009
- Testing
- Gain-Framed HPV Vaccination Message, Loss-Framed HPV Vaccination Message
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Parkinson Disease
Effect of Biological Sex on Multimodal Biomarkers of Disease Progression in Patients with Parkinson's Disease
The GENDERIZE-PD study is a research project to understand how biological sex affects the progression of Parkinson's disease (PD). PD is a brain disorder that causes both movement and non-movement symptoms.
- Trial name
- GENDERIZE-PD (NCT06790381)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Cigarette Smoking-Related Carcinoma
Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes
This early phase I trial studies potential differences between men and women when switching from the use of combustible cigarettes to the National Institute on Drug Abuse's Standard Research E-Cigarette (SREC).
- Trial name
- NCT03856515
- Testing
- Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Muscle Atrophy, Muscle Disuse Atrophy
Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy
The purpose of the proposed research is to define whether there are differences between females and males (i.e. sex-based differences) in the metabolic and mechanistic regulation of disuse-induced muscle atrophy in vivo in humans.
- Trial name
- NCT05314413
- Testing
- Single Leg Immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McGill University
Healthy, Alcohol Drinking
Binge Drinking of Alcohol Mixed With Energy Drinks
The purpose of the study is to assess the relevance of gender in the acute effects (subjective, physiological and driving-related skills) observed after controlled administration of alcohol in a binge-drinking pattern mixed with…
- Trial name
- ENERGYBINGE (NCT04616859)
- Testing
- Alcohol and Energy Drink (AmED)
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
Nicotine
Nicotine and Brain Imaging Research Study
The aim of this study is to assess the impact of smoking on cortical GABA levels in males and females. Using magnetic resonance spectroscopy (MRS), we will examine the impact of sex and menstrual cycle phase on brain…
- Trial name
- NCT01227343
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Marijuana Dependence
Sex Differences in Attentional Bias in Marijuana-dependent Individuals
The purpose of this study is to explore sex differences in cognitive functioning and responses to marijuana-related items, and to determine whether stress impacts these measures.
- Trial name
- NCT01179425
- Testing
- Cognitive stressor
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy Nutrition
Sex Differences in Metabolism Following a High-fat Meal
Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2…
- Trial name
- HFM (NCT05332301)
- Testing
- High-fat test meal
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsten Bell