Clinical trials: Sham-controlled
Hypertension
Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training
A randomized, sham-controlled intervention measuring the effects of isometric exercise training (IET) on blood pressure and cardiac autonomics.
- Trial name
- NCT05025202
- Testing
- Isometric exercise training
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
Healthy, Pain
Selective Nerve Stimulation (SNS) Pilot Study
The purpose of this study is to examine if a new device, the SNS (Selective Nerve Stimulator), is effective in changing the way nerves work as pain killing drugs sometimes do.
- Trial name
- SNS (NCT01259271)
- Testing
- Selective Nerve Stimulation (SNS) stimulator device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Codman & Shurtleff
Healthy Volunteers
The Effect of Low Level Light Therapy on Histamine- and Mucuna Pruriens-induced Pruritus in Healthy Volunteers
This is a prospective, double-blind, randomised, sham-controlled study whose primary aim is to test whether LLLT changes the intensity of itch after histamine application in healthy volunteers compared to sham application.
- Trial name
- NCT05369338
- Testing
- Low Level Light Therapy
- Where
- Austria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Electromagnetic Fields
Effect of Pulsed Electromagnetic Stimulation on DOMS
The aim of our study is to investigate the effect of Pulsed Electro Magnetic Field application on delayed muscle soreness in healthy Quadriceps femoris muscle.
- Trial name
- NCT05554874
- Testing
- Pulsed electromagnetic fields
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Impulsive Behavior, Suicidal Impulses
tDCS Applied to the OFC: Effects on Decision-Making and Impulse Control
In this study the investigators aim to assess whether transcranial direct current stimulation (tDCS; a safe and non-invasive method for modulating the activity of specific brain regions) when applied over the orbitofrontal cortex…
- Trial name
- NCT01805401
- Testing
- Transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Healthy Volunteers (HV), Transcranial Photobiomodulation
Frequency-Dependent Effects of Transcranial Photobiomodulation With Same Peak Irradiance on Cortical Excitability and Fine Motor Performance
This study investigates the frequency-dependent neuromodulatory effects of transcranial photobiomodulation (tPBM) over the primary motor cortex (M1) on cortical excitability and fine motor performance in healthy young adults.
- Conditions
- Healthy Volunteers (HV), Transcranial Photobiomodulation, Cortical Excitability
- Trial name
- NCT07752602
- Testing
- Transcranial Photobiomodulation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Insomnia, Primary
Study of Low Field Magnetic Stimulation (LFMS) on Measures of Sleep
Participants will be recruited and screened through ongoing studies in the sleep and anxiety disorders clinic. Participants with insomnia will be consented to complete several questionnaires, undergo a brief physical exam…
- Trial name
- NCT03050372
- Testing
- LFMS - Active
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cognitive Decline, Aging
Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed
This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized…
- Trial name
- NCT04534374
- Testing
- Resistance exercise
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Obesity, Weight Change Trajectory
Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide
Fractyl is evaluating Revita Duodenal Mucosal Resurfacing (DMR) in the REMAIN-1 pivotal study, which is designed to include two cohorts - an open label cohort referred to as REVEAL-1, and a randomized cohort, which includes both…
- Conditions
- Obesity, Weight Change Trajectory, Weight Change, Body
- Trial name
- REMAIN-1 (NCT06484114)
- Testing
- Revita Duodenal Mucosal Resurfacing (DMR)
- Where
- 32 sites in United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Fractyl Health Inc.
Clinical Study - RCT
Paraspinal Stimulation in Treating MPS
To test the hypothesis that the effect of either multiple deep intramuscular stimulation therapy [(DIMMST: trigger point deep dry needling (TrP-DDN) is combined with paraspinal deep intramuscular stimulation (PDIMS) and needle…
- Trial name
- DIMMST (NCT01708343)
- Testing
- DIMMST
- Where
- 3 sites in Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Primary Dysmenorrhea, Premenstrual Syndrome
Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms
This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on menstrual pain severity and premenstrual symptoms in women aged 18-30 years with primary dysmenorrhea.
- Conditions
- Primary Dysmenorrhea, Premenstrual Syndrome, Menstrual Pain
- Trial name
- NCT07409337
- Testing
- Self-Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Appetite Regulation, Food Intake
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Appetite
This study tests a new way to help control appetite. Researchers will use a wearable device on the ear. This device sends gentle electrical pulses to a nerve. This is called vagus nerve stimulation.
- Conditions
- Appetite Regulation, Food Intake, Obesity, Eating Behaviour
- Trial name
- NCT07444177
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anxiety, Fear
Effect of rTMS on Anxiety
Given the overall lack of treatment adherence/efficacy, side effects of drugs, and the substantial burden of anxiety disorders on the individual and on the national healthcare system, there is a critical need for mechanistic…
- Conditions
- Anxiety, Fear, Anxiety and Fear
- Trial name
- NCT03993509
- Testing
- rTMS to the right dlPFC
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Stroke Patient, Motor Impairment
Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)
Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event.
- Conditions
- Chronic Stroke Patient, Motor Impairment, Neurorehabilitation, Theta Burst Stimulation
- Trial name
- INSPIRE (NCT07439367)
- Testing
- Active iTBS, Tablet-based upper limb training
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Aging
The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics
The goal of this clinical trial is to assure the safety of long term therapeutic plasma exchange (TPE) with and without Intravenous Immunoglobulin (IVIG) and its effects on biomarkers and epigenetic biologic clocks in forty…
- Trial name
- NCT06534450
- Testing
- Therapeutic Plasma Exchange, IVIG
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dobri Kiprov
Psychomotor Speed, Sustained Attention
Effects of Exposure to a Single-electrode Electroencephalography-guided Binaural Beat Audio Track on Sustained Attention and Subjective Well-being Among Healthy Adults
This study aims to explore the potential of binaural beats, adjusted in real-time via EEG feedback, to positively influence brain states related to relaxation, focus, and cognitive performance.
- Conditions
- Psychomotor Speed, Sustained Attention, Inhibitory Control, Memory Encoding
- Trial name
- NCT07165899
- Testing
- EEG-Guided Binaural Beat Audio
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Healthy Volunteers, Neurophysiology
Investigating the Transcutaneous vs. Transcranial Mechanisms of Trigeminal Nerve Stimulation (eTNS) Using fMRI
Transcutaneous Trigeminal Nerve Stimulation (eTNS) is a non-invasive technique that modulates brain activity by applying electrical currents to the forehead.
- Conditions
- Healthy Volunteers, Neurophysiology, fMRI Research
- Trial name
- NCT07657260
- Testing
- Topical Lidocaine, Direct Current eTNS (DC-eTNS)
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Xidian University
Transcranial Direct Current Stimulation (tDCS), Ageing
Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults.
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Ageing, Executive Functioning, Transcranial Electric Stimulation
- Trial name
- NCT06991764
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Neuropathic Pain
BreEStim Pre-trial
The overall goal is to evaluate the effectiveness of different stimulation protocol of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) in managing neuropathic pain after spinal cord injury (SCI).
- Trial name
- NCT07878429
- Testing
- Single-pulse BreEStim Treatment, Multiple-pulse BreEStim Treatment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston