Clinical trials: Shock, Traumatic
Multiple Trauma, Polytrauma
Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients
Severe traumatic injury involving multiple body regions (polytrauma) carries a high risk of rapid bleeding, tissue hypoperfusion, and circulatory collapse.
- Conditions
- Multiple Trauma, Polytrauma, Hemodynamic Instability, Traumatic Shock
- Trial name
- NCT07850427
- Volunteers
- 300 people
- Sponsor
- Assiut University
Trauma, Hemorrhage
Transfusion for Major Haemorrhage in Trauma - Characteristics and Outcomes
Background: Trauma is the leading cause of death in young adults worldwide and the most common causes of mortality are haemorrhage and brain injury.
- Conditions
- Trauma, Hemorrhage, Shock, Traumatic, Acute Coagulopathy
- Trial name
- NCT05573841
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Karolinska University Hospital
Severe Trauma, Traumatic Shock
Efficacy and Safety of Early Use PCC in Severe Trauma
Uncontrolled hemorrhage within 24 hours after severe trauma is the main cause of death in trauma patients. Hemorrhagic shock may be accompanied by traumatic coagulopathy in the early stages of severe trauma.
- Trial name
- eFAST (NCT05738642)
- Testing
- 4 factor Prothrombin Complex Concentrates
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Injury
Prehospital Analgesia INtervention Trial (PAIN)
The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patients at select LITES Network…
- Trial name
- PAIN (NCT05437575)
- Testing
- Ketamine Hydrochloride, Fentanyl Citrate
- Where
- 11 sites in United States
- Volunteers
- 994 people
- Sponsor
- Jason Sperry
Hemorrhagic Shock, Traumatic Injury
Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial
Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in…
- Trial name
- TOWAR (NCT04684719)
- Testing
- low titer whole blood, Standard Care
- Where
- 10 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Jason Sperry
Hemorrhagic Shock, Trauma
REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
The purpose of this study is to demonstrate safety, effectiveness and benefit-risk profile of ResQFoam for the inhospital treatment of exsanguinating, intraabdominal haemorrhage due to trauma in patients where emergent laparotomy…
- Conditions
- Hemorrhagic Shock, Trauma, Exsanguinating Hemorrhage, Shock; Traumatic
- Trial name
- REVIVE (NCT02880163)
- Testing
- ResQFoam
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Arsenal Medical, Inc.
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Traumatic Brain Injury, Blunt Abdominal Trauma
Impact of Traumatic Brain Injury on Hemodynamic Instability in Patients With Blunt Bowel and Mesenteric Injuries
This retrospective cohort study aims to evaluate the impact of traumatic brain injury (TBI) on hemodynamic status in trauma patients with surgically confirmed blunt bowel and mesenteric injuries (BBMI).
- Conditions
- Traumatic Brain Injury, Blunt Abdominal Trauma, Hemodynamic Instability, Shock
- Trial name
- NCT06942091
- Testing
- Traumatic Brain Injury (TBI)
- Volunteers
- 169 people
- Sponsor
- Chang Gung Memorial Hospital
Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma
Renal Perfusion and the Development of AKI Following Traumatic Injury
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk.
- Conditions
- Traumatic Haemorrhagic Shock, AKI (Acute Kidney Injury) Due to Trauma, AKI - Acute Kidney Injury
- Trial name
- PERTAKI (NCT06917053)
- Testing
- Ultrasound (including contrast enhanced ultrasound), Sublingual incident dark field videomicroscopy, Urinary oxygen tension.
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust
Wounds and Injuries, Traumatic Shock
Prospective Validation of the SHOCKMATRIX Hemorrhage Predictive Model
Management of post-traumatic severe hemorrhage remains a challenge to any trauma care system. Studying integrated and innovative tools designed to predict the risk of early severe hemorrhage (ESH) and resource needs could offer a…
- Conditions
- Wounds and Injuries, Traumatic Shock, Hemorrhagic Shock
- Trial name
- SHOCKMATRIX (NCT06270615)
- Testing
- Ambispective validation of machine learning-based predictive model
- Where
- 8 sites in France
- Volunteers
- 1,584 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemorrhage, Shock, Traumatic
The AT-REBOA Target Trial
Temporary aortic occlusion can limit haemorrhage, can help to maintain perfusion to the heart and brain, and may be associated with improved survival.
- Conditions
- Hemorrhage, Shock, Traumatic, Cardiac Arrest Due to Trauma, Polytrauma
- Trial name
- AT-REBOA (NCT06312436)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 2 sites in Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Graz
Hemorrhagic Shock, Traumatic Brain Injury
Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
The LITES Network is an operational trauma center consortium which has the expertise, track record and confirmed capabilities to conduct prospective, multicenter, injury care and outcomes research of relevance to the Department…
- Trial name
- SWAT (NCT03402035)
- Where
- United States
- Volunteers
- 1,051 people
- Sponsor
- University of Pittsburgh
Trauma, Shock, Traumatic
Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study
We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG.
- Conditions
- Trauma, Shock, Traumatic, Morality
- Trial name
- NCT05549986
- Testing
- Observational
- Volunteers
- 105,641 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Trauma, Shock, Traumatic
Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients
In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.
- Trial name
- NCT04120870
- Testing
- Etomidate Injection 0.2 mg/kg, Ketamine injection 2 mg/kg
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Ajou University School of Medicine
Traumatic Shock, Hemorrhagic Shock
Prehospital Norepinephrine and Early Mortality in Traumatic Shock
The effect of early, prehospital norepinephrine use in patients with traumatic shock on mortality is unknown. Recent existing observational evidence from single system data (US, France, Japan) are conflicting.
- Conditions
- Traumatic Shock, Hemorrhagic Shock, Traumatic Brain Injury, Hypotension and Shock
- Trial name
- NCT04497155
- Testing
- Norepinephrine
- Volunteers
- 2,164 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Acute Respiratory Failure, Shock
Psychological Trauma and Resilience After Critical Illness
Critically ill patients experience a severe physical disease, associated with a psychotrauma, which may lead to post-traumatic stress disorder (17 to 30% of patients after critical illness) and persistent symptoms of anxiety and…
- Trial name
- RESIREA (NCT05193123)
- Where
- 23 sites in France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
Respiratory Distress Syndrome, Adult, Head Injuries, Closed
Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury
The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD)…
- Conditions
- Respiratory Distress Syndrome, Adult, Head Injuries, Closed, Shock, Shock, Traumatic
- Trial name
- NCT00113685
- Testing
- Hypertonic Saline-Dextran Solution, Lactated Ringer's Solution
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- University of Washington
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Traumatic Haemorrhagic Shock
An Observational Pilot Study of the Effects of Traumatic Haemorrhagic Shock and Resuscitation on the Microcirculation
Haemorrhage following major trauma is an important preventable cause of death. Those patients who survive may have a prolonged period of debility caused by failure of key body organs.
- Trial name
- MICROSHOCK (NCT02111109)
- Testing
- Side Stream Dark Field Microscopy
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- King's College Hospital NHS Trust
Injuries, Shock, Traumatic
Low Dose Vasopressin in Traumatic Shock
Hypothesis: We hypothesize that resuscitation regimens which minimize the total volume of resuscitation fluid, while restoring organ perfusion, will lead to lower morbidity and mortality in critically ill patients following…
- Trial name
- NCT00420407
- Testing
- normal saline control, vasopressin
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- The University of Texas Health Science Center at San Antonio