Clinical trials: Short Chain Fatty Acids
Iron Deficiency Anemia
Effect of Cow's Milk Kefir on Short Chain Fatty Acid (SCFA), Haemoglobin, and Ferritin Levels of Anemic Adolescent Girls
Introduction: The prevalence of anemia among adolescent girls in Indonesia is still quite high. According to the Indonesian Health Survey (IHS) in 2023, it was 18% and is still a national problem.
- Trial name
- NCT06957717
- Testing
- cow's milk kefir, pasteurized cow's milk
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lusyana Gloria Doloksaribu
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Obesity, Well-being
Gut Microbiome and Blood Markers After Habitual Herbal Tea Consumption
TeTrimTeas intends is to establish a long-term cooperative with local growers and producers who will become partners in the business, with profit share to local growers and producers.
- Trial name
- SRTT (NCT05862532)
- Testing
- TeTrimTeas welsh Herbal tea with rhubarb root, TeTrimTeas welsh Herbal tea with senna, TeTrimTeas welsh Herbal tea with green tea
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Chronic Obstructive Pulmonary Disease
Short Chain Fatty Acid Metabolism in COPD
The short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare the SCFA metabolism in COPD patients to healthy matched controls.
- Trial name
- SCFA (NCT03327181)
- Testing
- short chain fatty acid tracers
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Amyotrophic Lateral Sclerosis
Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients
This observational study explored the connection between the gut microbiota and the brain in patients with amyotrophic lateral sclerosis (ALS), specifically the modulation of short-chain fatty acids during disease progression and…
- Trial name
- IMPACT-ALS (NCT07178067)
- Testing
- Mediterranean diet
- Where
- Romania
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Healthy Adults, High Altitude
Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
Human milk oligosaccharides (HMOs) are the third-most abundant component in mothers' milk and are an important prebiotic factor for the development of the gut microbiota of infants, promoting the growth of certain beneficial…
- Conditions
- Healthy Adults, High Altitude, Isolation, Social
- Trial name
- NCT06133530
- Testing
- Human milk oligosaccharides, Maltose
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IU University of Applied Sciences
Synbiotics, Healthy Humans
Effect of Synbiotic on Composition of Human Gut Microbiota and Production of Short and Branched-chain Fatty Acids
This is a randomized, double-blind, placebo controlled, cross-over, single centre, 14 week clinical trial on healthy volunteers.
- Conditions
- Synbiotics, Healthy Humans, Composition of Gut Microbiota, Short and Branched-chain Fatty Acids
- Trial name
- NCT01716910
- Testing
- Combination of Lactobacillus acidophilus NCFM and cellobiose
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Role of Colonic Short Chain Fatty Acids in Obesity
The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes.
- Trial name
- NCT02562014
- Testing
- Glucose, Inulin, Resistant Starch
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Volunteers, Stress
Effects of Rifaximin on Gut Microbiota and Emotion
A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.
- Conditions
- Healthy Volunteers, Stress, Fear
- Trial name
- NCT05587036
- Testing
- Rifaximin
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Parkinson Disease
Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin Supplementation
Small exploratory open-label pilot study to assess the short-chain fatty acid (SCFA) prodrug tributyrin as a potential therapy for persons with Parkinson disease
- Trial name
- BUTTER (NCT05446168)
- Testing
- tributyrin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nicolaas Bohnen, MD, PhD
Body Composition Changes, Body Weight Changes
The Precision Nutrition New York Study
Dietary fiber has been shown to have beneficial effects on human health through its impact on microbes present in the gut. However, these effects can vary between individuals, and everyone may not reap the same health benefits by…
- Trial name
- PNNY (NCT06777498)
- Testing
- Whole Grain Intervention then fruits and vegetables, Fruit and Vegetable Intervention and then whole grains
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cornell University
Metabolic Syndrome
ButCoIns GUTS: - Gut Immunological Effects of Resistant Starch and Arabinoxylans in Subjects With Metabolic Syndrome
Dietary fibers including resistent starch, RS, and arabinoxylans, AX, have been shown to have anti-inflammatory effects and to change the composition of the faecal micro flora in the colon.
- Trial name
- NCT01618526
- Testing
- Western Style Diet, Healthy Carbohydrate Diet
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Postmenopausal Osteopenia, Bone Loss, Age Related
OsteoPreP: Food Supplements for Postmenopausal Bone Health
To evaluate the effect of 12 months of supplementation with a probiotic (probiotic plus prebiotic; 2 capsules per day) on relative change (%) in total volumetric bone density (measured using high resolution peripheral…
- Conditions
- Postmenopausal Osteopenia, Bone Loss, Age Related, Age-Related Sarcopenia, Glucose Metabolism Disorders
- Trial name
- OsteoPreP (NCT05348694)
- Testing
- Pendulum WBF-038
- Where
- Australia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Australian Catholic University
Early Breast Cancer
Mediterranean Diet and Inequality in Early Breast Cancer
Social determinants such as education, income, marital status, and social networks play a crucial role in cancer outcomes, including breast cancer.
- Trial name
- MEDITERRACARE (NCT07007169)
- Testing
- The goal is daily consumption of a minimum of 30 grams of dietary fiber and weekly consumption of a minimum of 30 different plant foods; minimizing the amount of ultra-processed food., Standard Diet
- Where
- 3 sites in Denmark
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Acute Myocardial Infarction
the Association of Intestinal Microbial Metabolites and Cardiac Function in Acute Myocardial Infarction
Recently, more and more studies have confirmed that intestinal flora is closely related to the occurrence and development of cardiovascular diseases.Bile acids (BAS), short chain fatty acids (SCFA) and trimethylamine oxide…
- Trial name
- NCT04955054
- Testing
- diagnose
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Short Chain Fatty Acids Bioavailability
Determination of the Bioavailability of Short Chain Fatty Acids in Healthy Humans
The purpose of the study is to evaluate the bioavailability of acetate, propionate and butyrate in healthy humans using a stable isotope technology.
- Trial name
- NCT01757379
- Testing
- 13C-labeled Acetate, 13C-labeled propionate, 13C-labeled butyrate
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy Mothers, Healthy Infants
Maternal High Fibre Fermented Diet Effect on Breastfed Infant Gut Microbiome
Breastfeeding is recommended for babies from birth to six months old because breast milk provides all the nutrients babies need for growth and development.
- Trial name
- MumBabyGut (NCT06977113)
- Testing
- High Fibre Fermented Food Diet, Control Habitual Diet
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Skin Dryness
Glyceryl Eicosapentaenoate Based Topic Products as an Irritant-free Cream and Serum for Hydration of Sensitive Skin
This exploratory study aims to verify the hydrating potential as well as the possible irritant effects of a 14-day hydrating treatment consisting of daily application of serum and cream to the skin of two dry targeted areas.
- Trial name
- COS-PBP-01 (NCT06219213)
- Testing
- Glyceryl Eicosapentaenoate serum, Glyceryl Eicosapentaenoate Cream A, Glyceryl Eicosapentaenoate Cream B
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- SCF Pharma
Dietary Fiber
Fiber Fermentation, and Short Chain Fatty Acid Kinetics and Utilization Inside the Gut and Systemic Circulation
Nowadays there is a strong interest in optimising human health through manipulation of non-digestible carbohydrates (NDC). NDC can be used as substrates by gut microbiota, which results in NDC degradation, production of…
- Trial name
- NCT04499183
- Testing
- fructo- and galacto-oligosaccharides
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wageningen University