Clinical trials: Short-chain Fatty Acids
Aging, Vascular Stiffness
Acetate and Age-associated Arterial Dysfunction
Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular…
- Conditions
- Aging, Vascular Stiffness, Vascular Dilation
- Trial name
- NCT05424263
- Testing
- Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Prematurity, Low Birth Weight Neonates
Metagenomic & Metabolomic Study: Bifidobacterium Probiotic Effects on Gut Microbiota & SCFA in Preterm NICU Infants
One million premature babies die due to prematurity complications, contributing the most to the causes of death in children under 5 years old.
- Trial name
- NCT07213414
- Testing
- Probiotics
- Where
- 3 sites in Indonesia
- Volunteers
- 72 people
- Sponsor
- Hasanuddin University
Obesity
Role of Colonic Short Chain Fatty Acids in Obesity
The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes.
- Trial name
- NCT02562014
- Testing
- Glucose, Inulin, Resistant Starch
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dysbiosis, Gut -microbiota
Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery
This study aims to evaluate whether probiotics can help maintain a healthy gut microbiome in patients receiving prophylactic antibiotics during elective orthopedic surgery.
- Conditions
- Dysbiosis, Gut -microbiota, Microbiome Analysis, Probiotic
- Trial name
- NCT06791993
- Testing
- Probiotic with Human Milk Oligosaccharides (HMO)
- Where
- 6 sites in United States, Thailand and 1 more
- Volunteers
- 60 people
- Sponsor
- Acibadem Maslak Hospital
Cardiometabolic Risk, Abdominal Obesity
Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers
The aim of this study is to demonstrate the beneficial effects on gut microbiota composition and activity of the diary intake of insoluble fiber (extract from Aspergillus Niger) for three weeks.
- Trial name
- FITACHITIN (NCT03773900)
- Testing
- Kiotransine (chitin-glucan from aspergillus niger)
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
IBS
Fecal Metabolome and the Intestinal Microbiota in Irritable Bowel Syndrome
The purpose of this study is to find out the relationship between the bile acids, fatty acids (fatty acids are part of the diet) and bacteria that are present in the intestines.
- Trial name
- IBS (NCT02981888)
- Testing
- X-Ray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity & Overweight, Gut -Microbiota
Effects of Monday-Thursday Sunnah Fasting on Short-Chain Fatty Acids, GLP-1, Satiety, and Nutritional Status in Obese Males
This quasi-experimental study investigated the effects of 8 weeks of Monday-Thursday Sunnah fasting on fecal short-chain fatty acids (SCFA), fasting total GLP-1, appetite regulation (hunger and satiety area under the curve)…
- Trial name
- NCT07703865
- Testing
- Monday-Thursday Sunnah Dry Fasting
- Where
- Indonesia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Muhammadiyah Jakarta
Dyslipidemias, Fatty Acid; Metabolic Disorder
Short-term Cocoa Supplementation and Elite Soccer Players
The goal of this interventional study was to investigate the impact of daily ingestion of 30g of dark chocolate on omega-3 fatty acid status and gut microbial community in professional soccer players.
- Trial name
- COCOA (NCT06073327)
- Testing
- dark chocolate, White chocolate
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Padova
Energy Expenditure, Metabolic Syndrome
The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome
During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.
- Conditions
- Energy Expenditure, Metabolic Syndrome, Anthropometry, Body Composition
- Trial name
- 12OATS (NCT06951386)
- Testing
- with short-chain fatty acids enriched drink, unenriched oat drink
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- KU Leuven
Emotions, Stress
The Role of Short Chain Fatty Acids in Microbiota-gut-brain Axis
The role of short chain fatty acids (SCFA) in the microbiota-gut-brain axis is examined in a sample of healthy volunteers. SCFA are the major products of bacterial fermentation of dietary fiber in the colon, and are hypothesised…
- Conditions
- Emotions, Stress, Fear
- Trial name
- SCFA-AP (NCT03688854)
- Testing
- SCFA mixture
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Metastatic Renal Cell Carcinoma
Measuring Treatment Response in Metastatic Renal Cell Cancer Using FPIA PET/CT
Renal cell carcinoma (RCC) is the most prevalent and lethal malignancy of the kidney. At the time of diagnosis, as many as a fifth of patients have metastatic disease (mRCC).
- Trial name
- NCT04802824
- Testing
- PET/CT
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Iron Deficiency Anemia
Effect of Cow's Milk Kefir on Short Chain Fatty Acid (SCFA), Haemoglobin, and Ferritin Levels of Anemic Adolescent Girls
Introduction: The prevalence of anemia among adolescent girls in Indonesia is still quite high. According to the Indonesian Health Survey (IHS) in 2023, it was 18% and is still a national problem.
- Trial name
- NCT06957717
- Testing
- cow's milk kefir, pasteurized cow's milk
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lusyana Gloria Doloksaribu
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University
Parkinson Disease, Parkinson Disease Dementia
Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments
The goal of this clinical trial is to learn if taking a tributyrin supplement works to improve memory and thinking and walking and balance in adults with Parkinson disease Parkinson disease dementia.
- Trial name
- BUTTER2 (NCT07154511)
- Testing
- Tributyrin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Prabesh Kanel
Intestinal Health
Fiber Fermentation Study
The aim of the study is to better understand the interplay between the intake of dietary fiber and intestinal bacteria, their metabolic activity and the effect on the intestinal barrier.
- Trial name
- NCT04570137
- Testing
- Dietary fiber supplementation
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Healthy Adult
Dietary Fibres on Gut Fermentation
The goal of this clinical trial is to learn if adding a rapidly fermenting fibre to a meal containing a slow fermenting fibre affects gut bacterial fermentation and digestive comfort in healthy adults aged 18 to 85 years.
- Trial name
- NCT07837297
- Testing
- SCF Alone, SCF and FOS (Single Dose), SCF and FOS (Split Dose)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bath
Healthy
Intervention With Legume Kernel Fibre in Healthy Subjects
The objective of the conducted study was to determine the efficacy of the native legume kernel fibres of Lupinus angustifolius Boregine (Boregine), Lupinus albus Typ Top (TypTop) and Glycine max Hefeng (Soy fibre) on prevention…
- Trial name
- NCT01036308
- Testing
- pure fibre-product, reference fibre
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Jena
Chronic Obstructive Pulmonary Disease, Aging
Fiber Metabolism in Chronic Obstructive Pulmonary Disease
The impact of fiber intake on short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare changes in SCFA metabolism after inulin vs.
- Trial name
- NCT04459156
- Testing
- Fiber Inulin
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Endstage Renal Disease
Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis
End-stage renal disease (ESRD) is associated with multiple comorbidities such as cardiovascular disease, anemia, mineral and bone disorders, malnutrition, body wasting, muscle loss (sarcopenia), neurological problems and…
- Trial name
- PLAN (NCT02976688)
- Testing
- Sodium Propionate
- Volunteers
- 15 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Child Development
Study of the Effects of Soy Exposure in Early Life on Bone Development and Gut Microbiota
In this project, the investigators aim to investigate the effects of soy consumption at early life on the development of gut microbiota and bone growth.
- Trial name
- NCT05763589
- Testing
- No intervention is involved
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The Hong Kong Polytechnic University