Clinical trials: Sialorrhea
Salivation
Acute Salivary Flow Rate Response to Transcutaneous Electrical Nerve Stimulation Versus Electro-acupuncture
Between available therapies for dry mouth is electrostimulation. Using an extra-oral device like TENS - which result in a statistically significant - increases the quantity of whole salivary flow rate production in xerostomia…
- Trial name
- NCT04211324
- Testing
- TENS, electro-acupuncture
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pneumonia, Mechanical Ventilation Complication
Oral Care of Intubated Intensive Care Patient
The aim of the research was to examine the effect of oral care bundle application on oral health, salivary pH (power of hydrogen), dry mouth and ventilator associated pneumonia in intubated patients compared to standard oral care.
- Conditions
- Pneumonia, Mechanical Ventilation Complication, Salivation, Dry Mouth
- Trial name
- NCT06258603
- Testing
- oral care bundle, clinical oral care
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Sialorrhea True Bulbar Palsy Medullary Injury
A Clinical Study of Ultrasound-guided Botulinum Toxin A Into Salivary Gland for Sialorrhea After True Bulbar Palsy
Sialorrhea refers to a group of syndromes characterized by excessive saliva secretion from the salivary glands or reduced clearance of oral saliva due to dysphagia, resulting in saliva overflowing from the corners of the mouth or…
- Trial name
- NCT07070817
- Testing
- Ultrasound-Guided Botulinum Toxin Type A (BoNT-A) Salivary Gland Injection, Control (Normal saline)
- Where
- China
- Sponsor
- houyajing
Cerebral Palsy, Drooling
Validation of the French Version of the Drooling Impact Scale in a Pediatric Cerebral Palsy Population
The aim of this study is to present the French translation of the Drooling Impact Scale (DIS-F) and to explore its validity, reliability and responsiveness to change in a group of children with Cerebral Palsy (CP)
- Trial name
- NCT03986333
- Where
- 6 sites in France
- Volunteers
- 55 people
- Sponsor
- Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française
Sialorrhea
Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults
Multicenter, open-label, outpatient study of the safety and effectiveness of repeated doses of MYOBLOC over a 1-year duration in adult subjects with troublesome sialorrhea.
- Trial name
- OPTIMYST (NCT02610868)
- Testing
- MYOBLOC
- Where
- 35 sites in United States, Belarus and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Sialorrhea, Clozapine Adverse Reaction
Prevalence of Sialorrhea in Patients Treated With Clozapine
Clozapine is the "gold standard" antipsychotic drug for the treatment of resistant schizophrenia or resistant psychosis. Despite the high rates of good clinical response, the potential side effects can limit its use.
- Conditions
- Sialorrhea, Clozapine Adverse Reaction, Quality of Life
- Trial name
- NCT04197037
- Testing
- Evaluation of sialorrhea through questionnaires that measure daytime and nighttime sialorrhea and the impact on quality of life.
- Where
- Spain
- Volunteers
- 129 people
- Sponsor
- Parc de Salut Mar
Drooling, Brain Injuries
Botulinum Toxin Injections Into the Salivary Glands of Cerebrospinal Children With Chronic Sialorrhea
French Health Authority describes sialorrhea (or drooling) as uncontrolled loss of saliva through the lips. Drooling is considered pathological after the age of three.
- Conditions
- Drooling, Brain Injuries, Chronic Sialorrhea, Children, Only
- Trial name
- SIALOBOT (NCT07067762)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Autism Spectrum Disorder, Chewing Problem
Oral Structural and Functional Problems in Children With Autism
This study aims to examine oral structural and functional problems in children with autism.
- Conditions
- Autism Spectrum Disorder, Chewing Problem, Drooling
- Trial name
- NCT06355141
- Testing
- oral assessment
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Saliva Altered
Application of Neuro-electrostimulation as a Treatment for Patients With Dry Mouth
Hyposalivation is a condition that has increased in frequency, primarily due to the degeneration of salivary glands caused by aging, polypharmacy, chronic or autoimmune diseases, or radiation treatments.
- Trial name
- NCT07593495
- Testing
- electrotherapy and physical therapy device
- Where
- Mexico
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma del Estado de Mexico
Hypersialorrhea (Excessive Salivation), Psychiatric Disorders
Chewing Gum as a Therapeutic Intervention for the Management of Hypersalivation
Psychiatric disorders often require specific treatments, usually involving medications called psychotropic drugs. While effective, these medications can cause significant side effects.
- Trial name
- Chew Daily (NCT07158359)
- Testing
- chewing gum mastication
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cadillac
Parkinson's Disease
Ipratropium Spray for Drooling Saliva in Parkinson's Disease
A phase II double blind clinical trial investigating the effects of ipratropium spray versus placebo spray in patients with Parkinson's disease.
- Trial name
- NCT00296946
- Testing
- ipratropium bromide (drug)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Sialorrhea
Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological Diseases
The efficacy of Botulinum toxin A (BoNT-A) in Asian population has not been properly studied and there is no literature available on the most efficacious dose of BoNT-A for sialorrhoea treatment.
- Trial name
- NCT02425176
- Testing
- Botulinum toxin A (BoNT-A) 50U, Botulinum toxin A (BoNT-A) 100U, Botulinum toxin A (BoNT-A) 200U
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Hypersalivation, Prevention of Drooling
Efficacy of Intravenous Glyco-P® in Patients Undergoing Procedure That Require Anesthesia Service
This observational study was designed to prove clinical efficacy of the well known "glycopyrrolate" which is considered an orphan drug in Thailand.
- Conditions
- Hypersalivation, Prevention of Drooling, Bradycardia, Reversal of Muscle Relaxants
- Trial name
- NCT02102542
- Where
- Thailand
- Volunteers
- 65 people
- Sponsor
- Mahidol University
Oral Disease
The Effect of Probiotics on Oral Health
This will be a double-blind, randomized, placebo-controlled two-arm parallel groups study of the effect of oral probiotics containing Streptococcus salivarius K12 on oral biofilm, salivation rate, and secretory immunoglobulin A…
- Trial name
- NCT05039320
- Testing
- Bactoblis
- Where
- Russia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Parkinson Disease
STN-DBS and the Risk of Sialorrhea
OBJECTIVE: The aims of this study were to assess the incidence rate and risk factors for sialorrhea in the long-term follow-up in a cohort of 170 patients with advanced Parkinson's disease [84 with deep brain stimulation (DBS)…
- Trial name
- NCT06090929
- Testing
- STN-DBS
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Qilu Hospital of Shandong University
Smell Dysfunction, Taste Dysfunction
Post-Covid-19 Patients Follow-up Study
Taste, smell, trigeminal and salivary function is impacted in post-COVID-19 patients
- Conditions
- Smell Dysfunction, Taste Dysfunction, Trigeminal Dysfunction, Salivary Dysfunction
- Trial name
- COVID-19 (NCT07571382)
- Testing
- Smell training
- Where
- Norway
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal
The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General Anesthesia
The application of lidocaine cream on oral secretions of LMA removal during the recovery period in ophthalmic surgical patients under general anesthesia: a randomized controlled trial
- Conditions
- Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal, Anesthesia Emergence, Secretion; Excess, Salivation
- Trial name
- LICOS (NCT06967064)
- Testing
- lidocaine cream
- Sponsor
- Sun Yat-sen University
Sjögren's Syndrome, Xerostomia
The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome
Sjögren's syndrome (SS) is a chronic, systemic and autoimmune disease characterized by inflammation, fibrosis and dysfunction of exocrine glands such as tear and salivary glands.
- Conditions
- Sjögren's Syndrome, Xerostomia, Dysphagia, Salivary Flow Rate
- Trial name
- SS (NCT05680064)
- Testing
- Tongue, lip, chin exercise group
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Saglik Bilimleri Universitesi
Clozapine-induced Hypersalivation
Metoclopramide as Treatment of Clozapine-induced Hypersalivation
Hypersalivation (sialorrhea or ptyalism) is known as a frequent, disturbing, uncomfortable adverse effect of clozapine therapy that can lead to noncompliance. Until now there is no effective enough treatment for this side effect.
- Trial name
- NCT02222220
- Testing
- Metoclopramide
- Where
- Israel
- Volunteers
- 61 people
- Sponsor
- Beersheva Mental Health Center
Amyotrophic Lateral Sclerosis, Sialorrhea
Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to determine the safety and efficacy of Myobloc in ALS patients who are having excessive drooling. The primary goal of the study is to determine if the patient perceives a benefit from the Myobloc in…
- Trial name
- NCT00125203
- Testing
- Botulinum toxin type B (Myobloc), Injection of salivary glands
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio