Clinical trials: Sibling Relations
Immunosuppression, Kidney Transplantation
HLA-Identical Sibling Renal Transplant Tolerance
The purpose of this study is to attempt to eliminate the necessity of immunosuppressive therapy for HLA-identical sibling Kidney Transplants, examine cellular chimerism of donor hematopoietic stem cell (DHSC) lineages for pairs…
- Conditions
- Immunosuppression, Kidney Transplantation, Graft Rejection
- Trial name
- NCT00619528
- Testing
- Infusion of Donor Hematopoietic Stem Cells and Campath-1H
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Embryonic Mosaicism, Embryo Culture Media
Media, Morphokinetics, and Mosaicism
Embryonic aneuploidy is the underlying etiology for the majority of failed implantation and miscarriage. Preimplantation genetic screening (PGS) with transfer of a euploid embryo has been advocated as a strategy for increasing…
- Conditions
- Embryonic Mosaicism, Embryo Culture Media, Embryo Morphokinetics, Infertility
- Trial name
- 3M (NCT03503877)
- Testing
- EmbryoScope Plus, GLOBAL MEDIA, SAGE MEDIA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy, Epidural Analgesia, Obstetric
Intelligence and Neurodevelopmental Outcome After Prenatal Exposure to Labour Epidural Analgesia: a Sibling Matched Clinical Ambidirectional Cohort Study
In Belgium, labour epidural analgesia (LEA) has been used for decades in the vast majority of vaginal deliveries (up to 83% of deliveries).
- Trial name
- NCT07014956
- Testing
- Labour epidural analgesia
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anxiety, Depression
Sibling-Support for Adolescent Girls (SSAGE)
Forcibly displaced adolescents face increased risks for mental illness and distress, with adolescent girls disproportionately affected in part due to the heightened gender inequity that often accompanies forced displacement.
- Conditions
- Anxiety, Depression, Mental Illness
- Trial name
- NCT06078124
- Testing
- Sibling Support for Adolescent Girls in Emergencies
- Where
- Colombia
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Suicide
Tool for Sibling and Children of Someone With Suicidal Thoughts
This study aims to investigate to what extent a website developed for siblings and children (16-25 years old) of someone with suicidal thoughts and/or behaviors is effective in improving perceived pressure, knowledge, attitudes…
- Trial name
- NCT06100575
- Testing
- Website (www.mee-leven.be)
- Where
- Belgium
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Ghent
Retinoblastoma, Cancer Survivor
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
This trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samples of tissue and saliva, and…
- Conditions
- Retinoblastoma, Cancer Survivor, Biological Sibling, Intraocular Retinoblastoma
- Trial name
- RIVERBOAT (NCT03932786)
- Testing
- Biospecimen collection, Vision assessment, Questionnaire administration
- Where
- 11 sites in United States, Canada
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Stress
Evaluation of a Resiliency Intervention for Siblings of Children With Autism Spectrum Disorder (ASD)
The proposed research has the following objectives: Based off findings from the "Development of a Resiliency Program for Siblings of Children with Autism Spectrum Disorder" qualitative focus group study (protocol 2019P002284)…
- Trial name
- SibChat (NCT04369417)
- Testing
- Relaxation Response Resiliency Program for Siblings of Children with ASD
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Genetic Disease, Communication
The Role of Family Functioning in Promoting Adaptation in Siblings of Individuals With Duchenne Muscular Dystrophy (DMD)
Background: We want to learn more about the relationship between the way families function and how children adapt to having a sibling with Duchenne muscular dystrophy (DMD).
- Trial name
- NCT01386515
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Survival, Embryo Quality
Oocyte Survival After Vitrification in an Open or Closed Device With Closed Storage.
The survival rate (and embryo quality) of donor oocytes with two commercially available devices.
- Trial name
- NCT01952184
- Testing
- CBSvit HS device, Cryotop SC device
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births (Hong et al., 1999; Kuleshova…
- Trial name
- NCT00986687
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- UConn Health
Schizophrenia and Related Disorders
Social Isolation and Aging in Schizophrenia
Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk of premature mortality, with a 10-20-year shorter lifespan relative to the general population.
- Trial name
- SIAS (NCT07419321)
- Where
- 4 sites in United States, Netherlands and 2 more
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Embryo Development
Effect of Abstinence Duration on Embryo Development
The aim the investigators study is to analyze the embryo development if oocytes of the participants are injected with sperm from a longer or shorter (2 hours) abstinence duration.
- Trial name
- NCT03323892
- Testing
- second masturbation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Autism Spectrum Disorder, Sibling Relations
Psychoeducation for Adult Siblings of ASD People (Autism Spectrum Disorder).
The purpose of this study was to evaluate the effectiveness of a novel psychoeducational program for adult siblings of autistic individuals, aiming to improve autism-related knowledge, well-being, resilience and sibling…
- Trial name
- NCT06361147
- Testing
- Psychoeducational program for ASD
- Where
- Greece
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Hellenic Mediterranean University
Family Relations, Sibling Relations
SIB-Time Web-application Tool for Typically Developing Siblings
In the United States, over 32.7 million people have special health, developmental, and mental health concerns. Most of these people have typically developing brothers and sisters.
- Trial name
- SIBTime (NCT04633473)
- Testing
- SIB-Time Web-Application Tool
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Bone Density, Gonadal Steroid Hormones
SIBlos EXtension Study (SIBEX)
Population-based, longitudinal cohort study designed to evaluate changes in bone mineral density, bone geometry, body composition, parameters reflecting muscle force, and sex steroid status in healthy young men, as well as their…
- Conditions
- Bone Density, Gonadal Steroid Hormones, Thyroid Hormones
- Trial name
- NCT02997033
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 709 people, healthy volunteers welcome
- Sponsor
- University Ghent
ART
A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI
The primary objective of this study is to evaluate whether the percentage of good quality embryo formation following Intracytoplasmic Sperm Injection (ICSI) is improved with the use of ZyMot method of microfluidic sperm…
- Trial name
- NCT04818593
- Testing
- ZyMot Multi Sperm Separation Device (850 ul), Density Gradient Centrifugation
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Infertility, Reproductive Sterility
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
- Trial name
- NCT02652143
- Testing
- AneVivo (Medical device for in vivo culture of embryos), comparator for embryo culture in vitro
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Anecova SA
Embryo Development
Culture Media and Blastocyst Development
The aim of this non-interventional study is to compare the blastulation rate per fertilized oocyte in two different single step culture media commercially available (GEMS and Irvine culture media).
- Trial name
- NCT03497052
- Testing
- In vitro culture in medium 1, In vitro culture in medium 2
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Clinica Valle Giulia
Embryonic Development, Embryo Morphokinetics
Embryo Culture Under Constant 5% vs Gradient 8%, 5%, 2% Oxygen Concentration
The purpose of this study is to investigate the development of human embryos in vitro under two different oxygen concentrations; a static 5% during all five days of culture or under an oxygen gradient, starting with 8% from day-0…
- Conditions
- Embryonic Development, Embryo Morphokinetics, Embryo Morphometry
- Trial name
- NCT05898178
- Testing
- Experimental intervention: 8-5-2% oxygen gradient concentration in the incubator
- Where
- Slovenia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Adenoma, CRC
A Prospective Study Into the Risk of Colorectal Neoplasms in Individuals With a Family History of Advanced Adenomas (Sibling AN Study)
To prospectively determine the prevalence of colorectal neoplasia in siblings of Hong Kong Chinese patients with advanced neoplasm compared with a sex and age-matched control population.
- Trial name
- AN (NCT01593098)
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong